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1-isopropyl-6-fluoropsilocin
O-4310, also known as 1-isopropyl-6-fluoropsilocin, is a serotonin receptor agonist of the substituted tryptamine, tryptamine family. It is the 1-isopropylated and 6-fluoro, flourinated chemical derivative, derivative of the serotonergic psychedelic psilocin. Pharmacology The drug is said to be a serotonin 5-HT2A receptor, 5-HT2A receptor agonist and to be highly binding selectivity, selective for activation of this receptor over the closely related serotonin 5-HT2B receptor, 5-HT2B and 5-HT2C receptor, 5-HT2C receptors. Its at the serotonin 5-HT2A receptor was reported to be 5nM and it was said to have an of 89% relative to serotonin. Conversely, O-4310 was said to be inactive at the serotonin 5-HT2B receptor, with no or reported for this receptor, and was claimed to have an of 592nM at the serotonin 5-HT2C receptor with an of approximately 50%. Hence, O-4310 appears to show about 118-fold selectivity for activation of the serotonin 5-HT2A receptor over the serotonin 5-HT2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1-Methyltryptamine
1-Methyltryptamine (1-methyl-T, 1-MT or 1-Me-T; code name PAL-637) is a serotonin receptor agonist and monoamine releasing agent of the substituted tryptamine, tryptamine family. It is the 1-methyl group, methyl chemical derivative, derivative of tryptamine (T; PAL-235). The drug is known to act as a serotonin 5-HT2A receptor, 5-HT2A receptor agonist (Ki = 473nM; = 209–4,560nM; = 55–99%), as a serotonin releasing agent ( = 53.1nM), and to be inactive in inducing the release of norepinephrine and dopamine ( = >10,000nM). Its activities at other serotonin receptors were not reported. 1-Methyltryptamine shows dramatically reduced affinity (pharmacology), affinity and receptor activation, activational potency (pharmacology), potency as well as reduced intrinsic activity, efficacy at the serotonin 5-HT2A receptor compared to tryptamine (which showed Ki = 13.1nM; = 7.36–99nM; = 101–104%). It also shows slightly reduced potency as a serotonin releasing agent and abolished act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |