UR-AK49 is a drug used in scientific research which acts as a potent antagonist for the

Neuropeptide Y Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the ma ...

Pancreatic polypeptide Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas. It regulates pancreatic secretion activities, and also impacts liver glycogen storage and gastrointestinal secretion. Its secretion may be impacted by ...

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

Y₄, and also as a

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...

at the

histamine Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered ...

receptors H₁ and H₂. UR-AK49 is a pure antagonist at Y₄ with no partial agonist effects, and although it is only slightly selective for Y₄ over the related Y₁ and Y₅ receptors, as the first non-peptide Y₄ antagonist developed UR-AK49 is expected to be useful in the study of this receptor and its role in the body.

References

Histamine agonists Imidazoles Neuropeptide Y antagonists Acylguanidines Cyclohexyl compounds {{nervous-system-drug-stub