''Phenuiviridae'' is a family of

negative-strand RNA virus Negative-strand RNA viruses (−ssRNA viruses) are a group of related viruses that have negative-sense, single-stranded genomes made of ribonucleic acid. They have genomes that act as complementary strands from which messenger RNA (mRNA) is s ...

es in the order ''

Bunyavirales ''Bunyavirales'' is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class ''Ellioviricetes''. The name ''Bunyavi ...

''.

Ruminant Ruminants (suborder Ruminantia) are hoofed herbivorous grazing or browsing mammals that are able to acquire nutrients from plant-based food by fermenting it in a specialized stomach prior to digestion, principally through microbial actions. The ...

s, camels, humans, and mosquitoes serve as natural hosts. Member genus ''Phlebovirus'' is the only genus of the family that has viruses that cause disease in humans (e.g. Rift Valley fever virus) except Dabie bandavirus.

Virology

Structure

Members of ''Phenuiviridae are'' enveloped viruses with helical

capsid A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or ma ...

morphology. Envelope glycoproteins of these viruses are distributed with

icosahedral symmetry In mathematics, and especially in geometry, an object has icosahedral symmetry if it has the same symmetries as a regular icosahedron. Examples of other polyhedra with icosahedral symmetry include the regular dodecahedron (the dual polyhedr ...

(T=12).

Genome

''Phenuiviridae'' is a

negative-sense In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complementarity (molecular biology), complement in specifying a sequence of am ...

single-stranded RNA virus family. Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment. Some members of the family have ambisense gene encoding on the S segment ( nucleocapsid proteins). The M segment includes envelope glycoproteins encoded in a polyprotein that is cleaved by host

protease A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes (increases reaction rate or "speeds up") proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the ...

s. Multiple different proteins can be encoded on the M segment due to

leaky scanning Leaky scanning is a mechanism used during the initiation phase of eukaryotic translation that enables regulation of gene expression. During initiation, the small 40S ribosomal subunit (as a 43S PIC) "scans" or moves in a 5' --> 3' direction along ...

by the ribosome.

Life cycle

RNA transcripts are

capped In sport, a cap is a player's appearance in a game at international level. The term dates from the practice in the United Kingdom of awarding a cap to every player in an international match of rugby football and association football. In the ea ...

through

cap snatching The first step of transcription for some negative, single-stranded RNA viruses is cap snatching, in which the first 10 to 20 residues of a host cell RNA are removed (snatched) and used as the 5′ cap and primer to initiate the synthesis of the na ...

, but not polyadenylated.

Translation Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text. The English language draws a terminological distinction (which does not exist in every language) between ''transla ...

is terminated by a hairpin sequence at the end of each RNA transcript.

Taxonomy

The following genera are recognized: * '' Bandavirus'' * '' Beidivirus'' * '' Coguvirus'' * '' Entovirus'' * '' Goukovirus'' * '' Horwuvirus'' * '' Hudivirus'' * '' Hudovirus'' * '' Ixovirus'' * '' Laulavirus'' * '' Lentinuvirus'' * '' Mobuvirus'' * '' Phasivirus'' * ''

Phlebovirus ''Phlebovirus'' is one of twenty genera of the family ''Phenuiviridae'' in the order ''Bunyavirales''. The genus contains 66 species. It derives its name from Phlebotominae, the vectors of member species '' Naples phlebovirus'', which is said to ...

'' * '' Pidchovirus'' * '' Rubodvirus'' * '' Tanzavirus'' * ''

Tenuivirus ''Tenuivirus'' is a plant virus genus belonging to ''Phenuiviridae'' family in the order ''Bunyavirales''. These plant viruses cause diseases in their host plants. Typical symptoms are chlorotic stripes on the affected leaves. This group of virus ...

'' * '' Uukuvirus'' * '' Wenrivirus''

References

Bunyavirales Virus families {{virus-stub