Heinrich Otto Wieland
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Heinrich Otto Wieland (; 4 June 1877 – 5 August 1957) was a German
chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe t ...
. He won the 1927
Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...
for his research into the bile acids.


Career

In 1901 Wieland received his doctorate at the University of Munich while studying under Johannes Thiele. In 1904 he completed his habilitation, then continued to teach at the university and starting in 1907 was a consultant for Boehringer Ingelheim. In 1914 he became associate professor for special topics in organic chemistry, and director of the Organic Division of the State Laboratory in Munich. From 1917 to 1918 Wieland worked in the service of the (KWI)
Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry The Fritz Haber Institute of the Max Planck Society (FHI) is a science research institute located at the heart of the academic district of Dahlem, in Berlin, Germany. The original Kaiser Wilhelm Institute for Physical Chemistry and Electrochem ...
in Dahlem then led by
Fritz Haber Fritz Haber (; 9 December 186829 January 1934) was a German chemist who received the Nobel Prize in Chemistry in 1918 for his invention of the Haber–Bosch process, a method used in industry to synthesize ammonia from nitrogen gas and hydroge ...
as an alternative to regular military service. There he was involved in weapons research for instance finding new synthetic routes for mustard gas. He is also credited with the first synthesis of
Adamsite Adamsite or DM is an organic compound; technically, an arsenical diphenylaminechlorarsine, that can be used as a riot control agent. DM belongs to the group of chemical warfare agents known as vomiting agents or sneeze gases. First synthesized in ...
. From 1913 to 1921, he was Professor at the
Technical University of Munich The Technical University of Munich (TUM or TU Munich; german: Technische Universität München) is a public research university in Munich, Germany. It specializes in engineering, technology, medicine, and applied and natural sciences. Establis ...
. He then moved to the
University of Freiburg The University of Freiburg (colloquially german: Uni Freiburg), officially the Albert Ludwig University of Freiburg (german: Albert-Ludwigs-Universität Freiburg), is a public research university located in Freiburg im Breisgau, Baden-Württemb ...
as successor of Ludwig Gattermann (he also assumed responsibility for Gattermanns famous cookbook). In Freiburg he started working on toad poisons and bile acids. In association with Boehringer Ingelheim he worked on synthetic alkaloids such as
morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. T ...
and strychnine. In 1925 Wieland succeeded
Richard Willstätter Richard Martin Willstätter FRS(For) HFRSE (, 13 August 1872 – 3 August 1942) was a German organic chemist whose study of the structure of plant pigments, chlorophyll included, won him the 1915 Nobel Prize for Chemistry. Willstätter invente ...
as Chemistry Professor at the
University of Munich The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's sixth-oldest university in continuous operatio ...
. In 1941, Wieland isolated the toxin alpha-amanitin, the principal active agent of one of the world's most poisonous mushrooms ''
Amanita phalloides ''Amanita phalloides'' (), commonly known as the death cap, is a deadly poisonous basidiomycete fungus, one of many in the genus ''Amanita''. Widely distributed across Europe, but now sprouting in other parts of the world, ''A. phalloides ...
''. Wieland tried successfully to protect people, especially
Jew Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""T ...
ish students, who were "racially burdened" after the
Nuremberg Laws The Nuremberg Laws (german: link=no, Nürnberger Gesetze, ) were antisemitic and racist laws that were enacted in Nazi Germany on 15 September 1935, at a special meeting of the Reichstag convened during the annual Nuremberg Rally of ...
. Students who were expelled because they were "racially burdened" could stay in Heinrich Wieland's group as chemists or as "Gäste des Geheimrats" (guests of the privy councillor).
Hans Conrad Leipelt Hans Conrad Leipelt (18 July 1921 – 29 January 1945) was an Austrian member of the White Rose resistance group in Nazi Germany. Background Leipelt was born in Vienna. His father, Konrad Leipelt, was a graduate in civil engineering, while his m ...
, a student of Wieland, was sentenced to death after collecting money for
Kurt Huber Kurt Huber (24 October 1893 – 13 July 1943) was a university professor and resistance fighter with the anti-Nazi group White Rose. For his involvement he was imprisoned and guillotined. Early life Huber was born in Chur, Switzerland, to G ...
's widow Clara Huber.


Family

Heinrich's father, Theodor Wieland (1846–1928) was a pharmacist with a doctorate in chemistry. He owned a gold and silver refinery in Pforzheim.''Interconnections and Independence: Heinrich Wieland (1877–1957) and His Era'' Elisabeth Vaupel Angew. Chem. Int. Ed. 2007, 46, 9154–9179 Heinrich Wieland was a cousin of Helene Boehringer, the wife of Albert Boehringer, who was the founder of Boehringer Ingelheim. From 1915 to the end of 1920, he was advisor at Boehringer Ingelheim and during this time he established the first scientific department of the company. Eva Wieland, Heinrich Wieland's daughter, was married to
Feodor Lynen Feodor Felix Konrad Lynen (; 6 April 19116 August 1979) was a German biochemist. In 1964 he won the Nobel Prize in Physiology or Medicine together with Konrad Bloch for their discoveries concerning the mechanism and regulation of cholesterol an ...
on 14 May 1937.


Heinrich Wieland Prize

Since 1964, the Heinrich Wieland Prize has been awarded annually. First to promote research on chemistry, biochemistry, physiology and clinical medicine of lipids and related substances, nowadays the prize is awarded for outstanding research on biologically active molecules and systems in the fields of chemistry, biochemistry, and physiology as well as on their clinical importance. The prize is among the most treasured international science awards and has a successful history of over 50 years. The Heinrich Wieland Prize has been sponsored by Boehringer Ingelheim from 2000 to 2010. From 2011, it has been awarded by the Boehringer Ingelheim Foundation. The awardees have always been selected by an independent Board of Trustees. Since 2014, it has been endowed with 100,000 euros.


References


External links

* * including the Nobel Lecture, December 12, 1928 ''The Chemistry of the Bile Acids'' * {{DEFAULTSORT:Wieland, Heinrich Otto 1877 births 1957 deaths People from Pforzheim 20th-century German chemists Nobel laureates in Chemistry German Nobel laureates Ludwig Maximilian University of Munich alumni Ludwig Maximilian University of Munich faculty Technical University of Munich faculty University of Freiburg faculty Foreign Members of the Royal Society Foreign associates of the National Academy of Sciences Commanders Crosses of the Order of Merit of the Federal Republic of Germany Recipients of the Pour le Mérite (civil class) Boehringer Ingelheim people