HOT-17 (2,5-dimethoxy-4-(β-isobutylthio)-''N''-hydroxyphenethylamine) is a

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science o ...

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace am ...

of the

2C family 2C (2C-''x'') is a general name for the family of psychedelic drug, psychedelic phenethylamines containing Methoxy, methoxy groups on the 2 and 5 carbon, positions of a benzene ring. Most of these compounds also carry lipophilic substituents at the ...

. It was synthesized by

Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymetha ...

and reported in his book '' PiHKAL''.PiHKAL #89 HOT-17
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Chemistry

HOT-17's full chemical name is 2- -(2- -(2-isobutylThio-">thio)-2,5-dimethoxy.html" ;"title="isobutylThio-.html" ;"title="isobutyl.html" ;"title="-(2-isobutyl">-(2-isobutylThio-">thio)-2,5-dimethoxy">isobutylThio-.html" ;"title="isobutyl.html" ;"title="-(2-isobutyl">-(2-isobutylThio-">thio)-2,5-dimethoxyphenyl-Nitrogen, ''N''-hydroxyl, hydroxyethanamine. It has chemical structure, structural properties similar to 2C-T-17 and to other drugs in the HOT- series, with the most closely related compounds being HOT-2 and HOT-7.

General information

The dosage range of HOT-17 is typically 70-120 mg and its duration is approximately 12–18 hours according to Shulgin. HOT-17 produces time distortion and general

psychedelia Psychedelia refers to the psychedelic subculture of the 1960s and the psychedelic experience. This includes psychedelic art, psychedelic music and style of dress during that era. This was primarily generated by people who used psychedelic ...

. It also has little to no body load.

References

{{Hallucinogenic phenethylamines Psychedelic phenethylamines Thioethers Phenol ethers Hydroxylamines

Chemistry

General information

See also

References