2CD-5EtO is a
homologue of the
psychedelic phenethylamine 2C-D, where the 5-
methoxy
In organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula .
On a benzene ring, the Hammett equation classifies a methoxy substituent at the ''para'' position a ...
group of 2C-D has been lengthened to an ethoxy group. 2CD-5EtO is a representative example of the so-called "tweetio" compounds discovered by
Alexander Shulgin and briefly mentioned in his book ''
PiHKAL''. They are homologues of the
2C family
2C (2C-''x'') is a general name for the family of psychedelic drug, psychedelic phenethylamines containing Methoxy, methoxy groups on the 2 and 5 carbon, positions of a benzene ring. Most of these compounds also carry lipophilic substituents at the ...
of drugs, where either one or both of the methoxy groups at the 2,5-positions of the aromatic ring have been replaced by ethoxy. The term tweetio was derived phonetically from the sound of the "2-ETO" derivatives.
Many tweetio derivatives of various 2C drugs have been synthesized and tested, including the 2-ethoxy homologues 2CD-2EtO, 2CB-2EtO, 2CI-2EtO, 2CT-2EtO, 2CT2-2EtO, 2CT4-2EtO and 2CT7-2EtO, the 5-ethoxy homologues 2CD-5EtO, 2CE-5EtO, 2CB-5EtO, 2CT-5EtO and 2CT2-5EtO, and the 2,5-diethoxy homologues 2CD-diEtO, 2CB-diEtO and 2CT2-diEtO. In general, the 2-ethoxy homologues were all several times less potent and somewhat shorter acting than the parent compounds, while the 2,5-diethoxy homologues were far less potent and qualitatively milder even at high doses.
The 5-ethoxy homologues however were of a similar potency to the parent compounds and much longer-lasting, with both 2CE-5EtO and 2CT2-5EtO lasting 24 hours or more.
References
External links
2C-D Entry in PiHKAL2C-E Entry in PiHKAL2C-T-2 Entry in PiHKAL
{{Phenethylamines
2C (psychedelics)
Serotonin receptor agonists