Siamon Gordon (born 29 April 1938) is a British

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

. He is

Glaxo Wellcome GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers an ...

Professor Emeritus ''Emeritus/Emerita'' () is an honorary title granted to someone who retirement, retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". ...

Cellular Pathology Cytopathology (from Greek , ''kytos'', "a hollow"; , ''pathos'', "fate, harm"; and , ''-logia'') is a branch of pathology that studies and diagnoses diseases on the cellular level. The discipline was founded by George Nicolas Papanicolaou in 1 ...

at the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

Education

He gained his medical degrees ( M.B. and Ch.B.) from the

University of Cape Town The University of Cape Town (UCT) (, ) is a public university, public research university in Cape Town, South Africa. Established in 1829 as the South African College, it was granted full university status in 1918, making it the oldest univer ...

South Africa South Africa, officially the Republic of South Africa (RSA), is the Southern Africa, southernmost country in Africa. Its Provinces of South Africa, nine provinces are bounded to the south by of coastline that stretches along the Atlantic O ...

. He earned his

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

from

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

, where he taught from 1971 to 1976. The rest of his career, from 1976 to 2008, was at the University of Oxford.

Career and research

He was on the

Faculty of 1000 F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers. F1000 offers a different research evaluation service from standard academic journals by offering peer-review after, rather than ...

. He was a visiting scientist at the

NIH The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

. He is on the Scientific Advisory Board of the American Asthma Foundation. Gordon is noted for his work on the phenotypic and functional diversity of

macrophages Macrophages (; abbreviated MPhi, φ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris and foreign substances, which do not have proteins that ...

. He began his studies on macrophages while in the laboratory of

Zanvil Cohn Zanvil Alexander Cohn (November 16, 1926 – June 28, 1993) was a cell biologist and immunologist who upon his death was described by ''The New York Times'' as being "in the forefront of current studies of the body's defenses against infection.", ...

in 1966. Upon his move to the

Sir William Dunn School of Pathology The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergr ...

in 1976 he continued this work and identified the pan-

macrophage Macrophages (; abbreviated MPhi, φ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris and foreign substances, which do not have proteins that ...

marker F4/80. Subsequent studies led to the identification of various scavenger receptors and the

cloning Cloning is the process of producing individual organisms with identical genomes, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction; this reproduction of an organism by itself without ...

of the

pattern recognition receptor Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed mainly by cells of th ...

, Dectin-1.

Publications

*''Macrophage Biology and Activation, Current Topics in Microbiology and Immunology'' (ed, 1992) * Siamon Gordon (ed) ''The Legacy of cell fusion'' Oxford University Press, 1994, *''Advances in Cell and Molecular Biology of Membranes and Organelles'' (ed, 1999) *Siamon Gordon, ed (1999). ''Phagocytosis: the host'' 5. JAI Press, * * *

References

{{DEFAULTSORT:Gordon, Siamon British pathologists Fellows of Exeter College, Oxford Fellows of the Royal Society Fellows of the Academy of Medical Sciences (United Kingdom) Statutory Professors of the University of Oxford University of Cape Town alumni Rockefeller University alumni Living people 1938 births