The respiratory center is located in the medulla oblongata and pons, in the

brainstem The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. The midbrain is conti ...

. The respiratory center is made up of three major respiratory groups of neurons, two in the medulla and one in the pons. In the medulla they are the dorsal respiratory group, and the ventral respiratory group. In the pons, the pontine respiratory group includes two areas known as the pneumotaxic center and the apneustic center. The respiratory center is responsible for generating and maintaining the rhythm of respiration, and also of adjusting this in homeostatic response to physiological changes. The respiratory center receives input from chemoreceptors, mechanoreceptors, the cerebral cortex, and the hypothalamus in order to regulate the rate and depth of breathing. Input is stimulated by altered levels of

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, and blood pH, by hormonal changes relating to stress and anxiety from the hypothalamus, and also by signals from the cerebral cortex to give a conscious control of respiration. Injury to respiratory groups can cause various breathing disorders that may require

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, and is usually associated with a poor prognosis.

Respiratory groups

The respiratory center is divided into three major groups, two in the medulla and one in the pons. The two groups in the medulla are the dorsal respiratory group and the ventral respiratory group. In the pons, the pontine respiratory group is made up of two areas – the pneumotaxic center and the apneustic center. The dorsal and ventral medullary groups control the basic rhythm of respiration. The groups are paired with one on each side of the brainstem.

Dorsal respiratory group

The dorsal respiratory group (DRG) has the most fundamental role in the control of respiration, initiating inspiration (inhalation). The DRG is a collection of neurons forming an elongated mass that extends most of the length of the dorsal medulla. They are near to the central canal of the

spinal cord The spinal cord is a long, thin, tubular structure made up of nervous tissue that extends from the medulla oblongata in the lower brainstem to the lumbar region of the vertebral column (backbone) of vertebrate animals. The center of the spinal c ...

, and just behind the ventral group. They set and maintain the rate of respiration. Most of the neurons are located in the nucleus of the solitary tract. Other important neurons are found in the adjacent areas including the reticular substance of the medulla. The solitary nucleus is the end-point for sensory information arriving from the pontine respiratory group, and from two cranial nerves – the

vagus nerve The vagus nerve, also known as the tenth cranial nerve (CN X), plays a crucial role in the autonomic nervous system, which is responsible for regulating involuntary functions within the human body. This nerve carries both sensory and motor fibe ...

, and the

glossopharyngeal nerve The glossopharyngeal nerve (), also known as the ninth cranial nerve, cranial nerve IX, or simply CN IX, is a cranial nerve that exits the brainstem from the sides of the upper Medulla oblongata, medulla, just anterior (closer to the nose) to t ...

. The solitary nucleus sends signals to the respiratory center from peripheral chemoreceptors, baroreceptors, and other types of receptors in the

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s in particular the stretch receptors. Thus, the dorsal respiratory group is seen as an integrating center that gives the ventral respiratory group output to modify the breathing rhythm.

Ventral respiratory group

The VRG maintains a constant breathing rhythm by stimulating the diaphragm and external intercostal muscles to contract, resulting in inspiration. In the medulla, the ventral respiratory group (VRG) consists of four groups of neurons that make up the exhalation (expiratory) area of respiratory control. This area is in the ventrolateral part of the medulla, about 5 mm anterior and lateral to the dorsal respiratory group. The neurons involved include those in the nucleus ambiguus, the nucleus retroambiguus, and the

interneuron Interneurons (also called internuncial neurons, association neurons, connector neurons, or intermediate neurons) are neurons that are not specifically motor neurons or sensory neurons. Interneurons are the central nodes of neural circuits, enab ...

s in the pre-Bötzinger complex. The VRG contains both inspiratory and expiratory neurons. The ventral respiratory group of neurons are active in forceful breathing and inactive during quiet, restful respirations. The VRG sends inhibitory impulses to the apneustic center.

Pontine respiratory group

In the pontine tegmentum in the pons, the pontine respiratory group (PRG) includes the pneumotaxic and apneustic centers. These have connections between them, and they both form the solitary nucleus.

Pneumotaxic center

The pneumotaxic center is located in the upper part of the pons. Its nuclei are the subparabrachial nucleus and the medial parabrachial nucleus. The pneumotaxic center controls both the rate and the pattern of breathing. The pneumotaxic center is considered an

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s in the phrenic nerve, effectively decreasing the tidal volume and regulating the respiratory rate. Absence of the center results in an increase in depth of respiration and a decrease in respiratory rate. The pneumotaxic center regulates the amount of air that can be taken into the body in each breath. The dorsal respiratory group has rhythmic bursts of activity that are constant in duration and interval. When a faster rate of breathing is needed the pneumotaxic center signals the dorsal respiratory group to speed up. When longer breaths are needed the bursts of activity are elongated. All the information that the body uses to help respiration happens in the pneumotaxic center. If this was damaged or in any way harmed it would make breathing almost impossible. One study on this subject was on anaesthetized paralyzed cats before and after bilateral vagotomy. Ventilation was monitored in awake and anaesthetized cats breathing air or . Ventilation was monitored both before and after lesions to the pneumatic center region and after subsequent bilateral vagotomy. Cats with pontine lesions had a prolonged inhalation duration. In cats, after anaesthesia and vagotomy, pontine transaction has been described as evoking a long sustained inspiratory discharges interrupted by short expiratory pauses. In rats on the other hand, after anaesthesia, vagotomy and pontine transaction, this breathing pattern was not observed, either in vivo or in vitro. These results suggest interspecies differences between rat and cat in the pontine influences on the medullary respiratory center.

Apneustic center

The apneustic center of the lower pons appears to promote inhalation by constant stimulation of the neurons in the medulla oblongata. The apneustic center sends signals to the dorsal group in the medulla to delay the 'switch off, the ''inspiratory off switch'' (IOS) signal of the inspiratory ramp provided by the pneumotaxic center. It controls the intensity of breathing, giving positive impulses to the neurons involved with inhalation. The apneustic center is inhibited by pulmonary stretch receptors and also by the pneumotaxic center. It also discharges an inhibitory impulse to the pneumotaxic center.

Respiratory rhythm

Breathing is the repetitive process of bringing air into the lungs and taking waste products out. The oxygen brought in from the air is a constant, on-going need of an organism to maintain life. This need is still there during sleep so that the functioning of this process has to be automatic and be part of the autonomic nervous system. The in-breath is followed by the out-breath, giving the respiratory cycle of inhalation and exhalation. There are three phases of the respiratory cycle: inspiration, post-inspiration or passive expiration, and late or active expiration. The number of cycles per minute is the respiratory rate. The respiratory rate is set in the respiratory center by the dorsal respiratory group, in the medulla, and these neurons are mostly concentrated in the solitary nucleus that extends the length of the medulla. The basic rhythm of respiration is that of quiet, restful breathing known as eupnea. Quiet breathing only requires the activity of the dorsal group which activates the diaphragm, and the external intercostal muscles. Exhalation is passive and relies on the elastic recoil of the lungs. When the metabolic need for oxygen increases, inspiration becomes more forceful and the neurons in the ventral group are activated to bring about forceful exhalation. Shortness of breath is termed dyspnea – the opposite of eupnea.

Clinical significance

Depression of the respiratory center can be caused by: brain trauma, brain damage, a brain tumour, or ischemia. A depression can also be caused by drugs including opioids, and sedatives. The respiratory center can be stimulated by

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, to produce faster and deeper breaths. Normally at therapeutic doses, this effect is not noticeable, but may be evident when respiration is already compromised.