Lawrence S.B. Goldstein (born February 20, 1956, in
Buffalo, New York
Buffalo is a Administrative divisions of New York (state), city in the U.S. state of New York (state), New York and county seat of Erie County, New York, Erie County. It lies in Western New York at the eastern end of Lake Erie, at the head of ...
) is a professor of cellular and molecular medicine at
University of California, San Diego
The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Es ...
and investigator with the
Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...
. He receives grant funding from the
NIH
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
, the Johns Hopkins ALS Center, the HighQ Foundation, and the
California Institute for Regenerative Medicine
The California Institute for Regenerative Medicine (CIRM) is a state agency that supports research and education in the fields of stem cell and gene therapies. It was created in 2004 after 59% of California voters approved California Proposition ...
. In 2020 he was elected to the
National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
.
Biography
Dr. Goldstein received his B.A. degree in biology and genetics from
UCSD
The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public land-grant research university in San Diego, California, United States. Established in 1960 near the pre-existing ...
in 1976 and his Ph.D. degree in genetics from the
University of Washington, Seattle
The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Unite ...
in 1980. He did postdoctoral research at the
University of Colorado at Boulder
The University of Colorado Boulder (CU Boulder, CU, or Colorado) is a Public university, public research university in Boulder, Colorado, United States. Founded in 1876, five months before Colorado became a Federated state, state, it is the fla ...
from 1980 to 1983 and the
Massachusetts Institute of Technology
The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...
in 1983/1984. He was assistant, associate and full professor at
Harvard University
Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...
in the Department of Cellular and Developmental Biology from 1984 to 1993 and moved to
UCSD
The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public land-grant research university in San Diego, California, United States. Established in 1960 near the pre-existing ...
and
HHMI
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...
in 1993. His awards include a Senior Scholar Award from the Ellison Medical Foundation, an
American Cancer Society
The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and '' Cancer Cytopathology''.
History
The society w ...
Faculty Research Award, and the Loeb Chair in Natural Sciences when he was at Harvard University.
His research is focused on understanding the molecular mechanisms of intracellular movement in neurons and the role of transport failures in neurodegenerative diseases. His lab provided the first molecular descriptions of
kinesin
A kinesin is a protein complex belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases, a typ ...
structure and organization, and also discovered important links between transport processes and diseases such as
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...
and
Huntington's disease
Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly Genetic disorder#Autosomal dominant, inherited. It typically presents as a triad of progressive psychiatric, cognitive, and ...
. Dr. Goldstein has also had an active role in National Science policy. He has served on many public science advisory committees, has written about, spoken about, and been interviewed on numerous occasions on science issues by print and broadcast media, and has testified on a number of occasions in the U.S. House of Representatives and the Senate about NIH funding and stem cell research. As a cofounder and consultant of the biotechnology compan Cytokinetics, Inc. he has also had an active role in private industry. Goldstein has also served as elected secretary of the