Isoorientin (homoorientin) is a

flavone Flavone is an organic compound with the formula . A white solid, flavone is a derivative of chromone with a phenyl (Ph) substituent adjacent to the ether group. The compound is of little direct practical importance, but substituted derivatives, ...

, a chemical flavonoid-like compound. It is the luteolin-6-''C''-glucoside.

Natural occurrence

Isoorientin can be isolated from the

passion flower ''Passiflora'', known also as the passion flowers or passion vines, is a genus of about 550 species of flowering plants, the type genus of the family Passifloraceae. ''Passiflora'' species are widely cultivated for their striking flowers, fla ...

, ''

Vitex negundo ''Vitex negundo'', commonly known as the Chinese chaste tree, five-leaved chaste tree, or horseshoe vitex, or nisinda is a large aromatic shrub with quadrangular, densely whitish, tomentose branchlets. It is widely used in folk medicine, pa ...

'', ''

Terminalia myriocarpa ''Terminalia myriocarpa'', the East Indian almond, is a tree species in the genus ''Terminalia'' found in Southeast Asia. Ecology The larvae of the moth '' Acrocercops terminaliae'' feed on ''T. myriocarpa''. Chemistry The phenolic compounds m ...

'', the

Açaí palm The açaí palm (, , from Nheengatu ''asai''), '' Euterpe oleracea'', is a species of palm tree (Arecaceae) cultivated for its fruit (açaí berries, or simply açaí), hearts of palm (a vegetable), leaves, and trunk wood. Global demand for th ...

, and ''

Swertia japonica ''Swertia'' is a genus in the Gentianaceae, gentian family containing plants sometimes referred to as the felworts. Some species bear very showy purple and blue flowers. Many members of this genus have medicinal and cultural purposes. Plants of ...

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Potential pharmacology

Isoorientin has been studied for its potential pharmacological activity.

Bioassay-directed fractionation Fractionation is a separation process in which a certain quantity of a mixture (of gasses, solids, liquids, enzymes, or isotopes, or a suspension) is divided during a phase transition, into a number of smaller quantities (fractions) in which t ...

techniques led to isolation of isoorientin as the main

hypoglycaemic Hypoglycemia (American English), also spelled hypoglycaemia or hypoglycæmia (British English), sometimes called low blood sugar, is a fall in blood sugar to levels below normal, typically below 70 mg/dL (3.9 mmol/L). Whipple's tria ...

component in ''

Gentiana olivieri ''Gentiana olivieri'' (Chinese: xie wan que qin jiao) is a species of flowering plant in the family ''Gentianaceae Gentianaceae is a family of flowering plants of 105 genera and about 1600 species. Etymology The family takes its name from the ...

''. Studies also showed that isoorientin is a potential

neuroprotective Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal l ...

compound against

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...

Metabolism

Isoorientin 3'-O-methyltransferase In enzymology, an isoorientin 3'-O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + isoorientin \rightleftharpoons S-adenosyl-L-homocysteine + isoscoparin Thus, the two substrates of this enzyme a ...

References

{{flavone Flavone glucosides C-glycoside natural phenols

Natural occurrence

Potential pharmacology

Metabolism

See also

References