Intravenous sugar solution, also known as dextrose solution, is a mixture of

dextrose Glucose is a sugar with the molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae during photosynthesis from water an ...

(glucose) and

water Water is an inorganic compound with the chemical formula . It is a transparent, tasteless, odorless, and Color of water, nearly colorless chemical substance. It is the main constituent of Earth's hydrosphere and the fluids of all known liv ...

. It is used to treat low blood sugar or water loss without

electrolyte An electrolyte is a substance that conducts electricity through the movement of ions, but not through the movement of electrons. This includes most soluble Salt (chemistry), salts, acids, and Base (chemistry), bases, dissolved in a polar solven ...

loss. Water loss without electrolyte loss may occur in

fever Fever or pyrexia in humans is a symptom of an anti-infection defense mechanism that appears with Human body temperature, body temperature exceeding the normal range caused by an increase in the body's temperature Human body temperature#Fever, s ...

, hyperthyroidism, high blood calcium, or diabetes insipidus. It is also used in the treatment of high blood potassium, diabetic ketoacidosis, and as part of parenteral nutrition. It is given by injection into a vein. Side effects may include irritation of the

vein Veins () are blood vessels in the circulatory system of humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are those of the pulmonary and feta ...

in which it is given, high blood sugar, and swelling. Excess use may result in low blood sodium and other electrolyte problems. Intravenous sugar solutions are in the crystalloid family of medications. They come in a number of strengths including 5%, 10%, and 50% dextrose. While they may start out hypertonic they become hypotonic solutions as the sugar is metabolised. Versions are also available mixed with saline. Dextrose solutions for medical use became available in the 1920s and 1930s. It is on the World Health Organization's List of Essential Medicines.

Medical uses

Administering a 5% sugar solution peri- and postoperatively usually achieves a good balance between starvation reactions and hyperglycemia caused by sympathetic activation. A 10% solution may be more appropriate when the stress response from the reaction has decreased, after approximately one day after surgery. After more than approximately two days, a more complete regimen of

total parenteral nutrition Parenteral nutrition (PN), or intravenous feeding, is the feeding of nutritional products to a person intravenously, bypassing the usual process of eating and digestion. The products are made by pharmaceutical compounding entities or standard pha ...

is indicated. In patients with hypernatremia and euvolemia, free water can be replaced using either 5% D/W or 0.45% saline. In patients with fatty-acid metabolism disorder (FOD), 10% solution may be appropriate upon arrival to the emergency room.

Side effects

Intravenous glucose is used in some Asian countries as a pick-me-up, for "energy", but is not part of routine medical care in the United States where glucose solution is a prescription drug. Asian immigrants to the United States are at risk of infection if they seek intravenous glucose treatment. It may be had at storefront clinics catering to Asian immigrants, despite having no more effect than drinking sugared water. The procedure is commonly called "ringer". Concentrated dextrose solutions should not be administered subcutaneously or intramuscularly, as they can cause cell death via dehydration and subsequent necrosis.

Types

Types of glucose/dextrose include: * D5W (5% dextrose in water), which consists of 278 mmol/L dextrose * D5NS (5% dextrose in normal saline), which, in addition, contains normal saline (0.9% w/v of NaCl). ** D5 1/2NS 5% dextrose in half amount of normal saline (0.45% w/v of NaCl). * D5LR (5% dextrose in lactated Ringer solution) * D50 – 50% dextrose in water The percentage is a mass concentration, so a 5% glucose/dextrose solution contains 50 g/ L of glucose/dextrose (5 g per 100 ml). This usage is imprecise but widely used, as discussed at '' Mass concentration (chemistry) § Usage in biology''. Glucose provides energy 4 kcal/gram, so a 5% glucose solution provides 0.2 kcal/ml. If prepared from ''dextrose monohydrate'', which provides 3.4 kcal/gram, a 5% solution provides 0.17 kcal/ml.Calculating Parenteral Feedings
D. Chen-Maynard at California State University, San Bernardino. Retrieved September 2010. HSCI 368

References

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