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CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.
CD151 has been shown to
Raph blood group system
in the
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.Interactions
CD151 has been shown to interact
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with CD46
CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the ''CD46'' gene. CD46 is an inhibitory complement receptor.
Gene
This gene is fou ...
.
See also
*Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
* Tetraspanin
Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.
Tetraspanins, also referred to as the transmembrane 4 superfamily (TM4SF) proteins, have four transmembrane alpha-helices and two extracellular domains, on ...
References
Further reading
* * * * * * * * * * * * * * * * * * *External links
Raph blood group system
in the
BGMUT
The BGMUT (Blood Group antigen gene MUTation) Database documents allelic variations in the genes encoding for human blood group systems. It was set up in 1999 through an initiative of the Human Genome Variation Society ( HGVS). Since 2006, it has b ...
blood group antigen gene mutation database
*
Clusters of differentiation
{{membrane-protein-stub
Blood antigen systems
Transfusion medicine