Antonio Vidal-Puig (born
Valencia
Valencia ( va, València) is the capital of the autonomous community of Valencia and the third-most populated municipality in Spain, with 791,413 inhabitants. It is also the capital of the province of the same name. The wider urban area al ...
,
Spain
, image_flag = Bandera de España.svg
, image_coat = Escudo de España (mazonado).svg
, national_motto = ''Plus ultra'' (Latin)(English: "Further Beyond")
, national_anthem = (English: "Royal March")
, i ...
June 12, 1962) is a Spanish
medical doctor and
scientist
A scientist is a person who conducts scientific research to advance knowledge in an area of the natural sciences.
In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosoph ...
who works as a
Professor
Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professors ...
of
Molecular Nutrition and
Metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...
at the
University of Cambridge
The University of Cambridge is a public collegiate research university in Cambridge, England. Founded in 1209 and granted a royal charter by Henry III in 1231, Cambridge is the world's third oldest surviving university and one of its most pr ...
(
UK), best known for advancing the concept that pharmacological targeting of
brown fat
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). Brown adipose tissue is found in almost all mammals.
Classification of brown fat refers to two distinct cell populations with si ...
may serve to treat
overweight and
obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's ...
in affected individuals, as well as for introducing the concept of
adipose tissue
Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular ...
"expandability" as an important factor in the
pathogenesis
Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pat ...
of
insulin resistance in the context of
positive energy balance. His published work focuses on areas such as adipose tissue
metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...
and
lipotoxicity Lipotoxicity is a metabolic syndrome that results from the accumulation of lipid intermediates in non-adipose tissue, leading to cellular dysfunction and death. The tissues normally affected include the kidneys, liver, heart and skeletal muscle. Lip ...
, regulation of
insulin secretion, and the
pathophysiology of
metabolic syndrome,
obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's ...
, and
type 2 diabetes
Type 2 diabetes, formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urinatio ...
.
Education
Vidal-Puig studied medicine at
University of Valencia
The University of Valencia ( ca-valencia, Universitat de València ; also known as UV) is a public research university located in the city of Valencia, Spain. It is one of the oldest surviving universities in Spain, and the oldest in the Vale ...
Medical School, and trained in
endocrinology
Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...
at the
University of Granada Medical School. He held post-doctoral positions in
Boston
Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- mo ...
at the
Massachusetts General Hospital and
Beth Israel Hospital,
Harvard Medical School
Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
, from 1992–1999, where his mentors included
Jeff Flier, Brad Lowell, David Moller, and Leo Krall.
In 2015 he completed the
Executive Master of Business Administration at the
Cambridge Judge Business School
Cambridge Judge Business School is the business school of the University of Cambridge. The School is a provider of management education. It is named after Sir Paul Judge, a founding benefactor of the school.
The School is considered to be par ...
.
Career
Vidal-Puig established his research laboratory (TVP Lab) at the
Institute of Metabolic Science, of the University of Cambridge in 2000, and became a Professor of Molecular Nutrition and Metabolism, as well as an
Honorary Consultant in Metabolic Medicine. He is also an Associate Faculty of the
Wellcome Sanger Institute
The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.
It is located on the Wellcome ...
. In 2014 he was elected a Fellow of the
Academy of Medical Sciences (UK).
Together with Matej Orešič, in 2014 he edited an essay volume "A Systems Biology Approach to Study Metabolic Syndrome".
His academic engagements outside the UK include his affiliation with the ''Centre on Artificial Intelligence for Humankind'' at the
National University of Singapore Business School. Since 2019 he has been associated with the newly launched Cambridge University Nanjing Centre for Technology. As a Visiting Professor at
Nanjing University
Nanjing University (NJU; ) is a national public research university in Nanjing, Jiangsu. It is a member of C9 League and a Class A Double First Class University designated by the Chinese central government. NJU has two main campuses: the Xian ...
, he is engaged in studies concerning aspects of the epidemic of obesity and diabetes occurring in China. He is also a Chair of the Life Sciences Panel and a recipient of a Principal Investigator award of the
European Research Council.
Scientific work
TVP Lab
Vidal-Puig's research laboratory in Cambridge is devoted to exploring "the molecular mechanisms involved in controlling energy expenditure, fat deposition, and the mechanisms controlling the partition of energy towards oxidation or storage".
More specifically it works on lipotoxic effects on insulin sensitivity, activation of thermogenesis in adipose tissue, molecular mechanisms controlling ''energy expenditure'' and brown fat activation, and modulation of fatty acid oxidation in skeletal muscle.
Theoretical
Novel concepts worked on by Vidal-Puig include:
* Adipose tissue expandability hypothesis. The concept was advanced by him in 2006. According to the hypothesis, the expansion of adipose tissue (AT) is a normal phenomenon when an individual undergoes sustained positive energy balance, providing strategic fuel storage. However, it may reach a threshold beyond which
toxic effects ensue: abnormal accumulation of lipids in organs such as muscle, liver, heart, kidney; accumulation of macrophages in AT, and spillover of proinflammatory molecules from metabolically stressed AT (lipotoxicity). These eventually lead to disease states typically accompanying
obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's ...
, such as
metabolic syndrome,
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...
,
atherosclerosis
Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheromatous plaque. At onset there are usually no s ...
,
hypertension, and
heart attack
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which ma ...
s. This expandability concept has gained considerable acceptance among experts.
*Brown fat targeting to treat obesity. Since brown fat burns lipids to produce heat through the
uncoupling of its mitochondria (
thermogenesis
Thermogenesis is the process of heat production in organisms. It occurs in all warm-blooded animals, and also in a few species of thermogenic plants such as the Eastern skunk cabbage, the Voodoo lily ('' Sauromatum venosum''), and the giant w ...
), this phenomenon has been historically suggested as a method to fight obesity. Vidal-Puig's contributions have included studies of the neural, metabolic, and genetic control of the thermogenic uncoupling of adipocyte mitochondria, and the therapeutically oriented testing of possible synthetic activators of such uncoupling. In reports attracting media coverage, his team unveiled the existence of naturally occurring, pro-thermogenic biochemical mechanisms controlling mitochondrial uncoupling in fat cells, a finding with potential use to treat overweight. and control thermogenesis
Research topics
Research articles where Vidal-Puig is an author will be found in current entries on
Adipogenesis Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as preadipocy ...
,
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between c ...
,
Lipidomics
Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems The word " lipidome" is used to describe the complete lipid profile within a cell, tissue, organism, or ecosystem and is a subset of the "metabol ...
,
Lipotoxicity Lipotoxicity is a metabolic syndrome that results from the accumulation of lipid intermediates in non-adipose tissue, leading to cellular dysfunction and death. The tissues normally affected include the kidneys, liver, heart and skeletal muscle. Lip ...
,
Macrophages
Macrophages (abbreviated as M φ, MΦ or MP) ( el, large eaters, from Greek ''μακρός'' (') = large, ''φαγεῖν'' (') = to eat) are a type of white blood cell of the immune system that engulfs and digests pathogens, such as cancer ce ...
,
Metabolic syndrome,
Metabolomics
Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprin ...
,
Mitophagy Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. The process of mitophagy was first described over a hundred years ago by Margaret Reed Lewis and Warren Harmo ...
,
Nicotinamide phosphoribosyltransferase,
Non-alcoholic fatty liver disease,
Pyruvate carboxylase
Pyruvate carboxylase (PC) encoded by the gene PC is an enzyme () of the ligase class that catalyzes (depending on the species) the physiologically irreversible carboxylation of pyruvate to form oxaloacetate (OAA).
Image:Pyruvic-acid-2D-sk ...
,
Resistin
Resistin also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich peptide hormone derived from adipose tissue that in humans is encoded by t ...
,
Senotherapy,
Stearoyl-CoA desaturase-1
Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-C ...
,
Uncoupling protein
An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter. An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from th ...
,
UCP2, and
UCP3.
Research allies
Notable Cambridge scientists with whom Vidal-Puig has shared paper authorship include
Krishna Chatterjee,
Sadaf Farooqi,
Nita Forouhi,
Giles Yeo,
Stephen O'Rahilly, and
Nick Wareham.
Honours
Vidal-Puig gave the 2015
FEBS National Lecture, the 2016 Maimonides Lecture Award by the
University of Córdoba, and the 2019
Sir Philip Randle Lecture sponsored by the
British Biochemical Society.
He has been awarded the Lilly Foundation Distinguished Career Award (2015), the
Hippocrates
Hippocrates of Kos (; grc-gre, Ἱπποκράτης ὁ Κῷος, Hippokrátēs ho Kôios; ), also known as Hippocrates II, was a Greek physician of the classical period who is considered one of the most outstanding figures in the history o ...
International Award for Medical Research on Human Nutrition given by the ''Real Academia de Medicina y Cirugía'' of the
Principality of Asturias
Asturias (, ; ast, Asturies ), officially the Principality of Asturias ( es, Principado de Asturias; ast, Principáu d'Asturies; Galician-Asturian: ''Principao d'Asturias''), is an autonomous community in northwest Spain.
It is coextensiv ...
(2015), and the
Society for Endocrinology Medal (2017).
External links
Antonio Vidal-Puig's academic websiteTVP Lab website
References
{{DEFAULTSORT:Vidal-Puig, Antonio
Living people
Spanish scientists
People from Valencia
1962 births