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Short-chain Dehydrogenase
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called 'insect-type', or 'short-chain' alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains. Subfamilies * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Family
A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes a corresponding protein with a 1:1 relationship. The term "protein family" should not be confused with family as it is used in taxonomy. Proteins in a family descend from a common ancestor and typically have similar three-dimensional structures, functions, and significant sequence similarity. Sequence similarity (usually amino-acid sequence) is one of the most common indicators of homology, or common evolutionary ancestry. Some frameworks for evaluating the significance of similarity between sequences use sequence alignment methods. Proteins that do not share a common ancestor are unlikely to show statistically significant sequence similarity, making sequence alignment a powerful tool for identifying the members of protein families. Families are sometimes grouped together into larger clades called superfamilies based on st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DHRS2
Dehydrogenase/reductase SDR family member 2 is an enzyme that in humans is encoded by the ''DHRS2'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... References Further reading * * * * * * * * External links * * {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HPGD
Hydroxyprostaglandin dehydrogenase 15-(NAD) (the HUGO-approved official symbol = HPGD; HGNC ID, HGNC:5154), also called 15-hydroxyprostaglandin dehydrogenase AD+ is an enzyme that in humans is encoded by the ''HPGD'' gene. In melanocytic cells HPGD gene expression may be regulated by MITF. Functions 15-hydroxy prostaglandin dehydrogenase (HPGD) is an enzyme belongs to the family of oxidoreductases, specifically the short chain dehydrogenase/reductase family 36C member 1. This protein coding gene encodes a member of the short chain alcohol dehydrogenase protein family. HPGD catalyzes the first step in the catabolic pathway of prostaglandins and is therefore responsible for the metabolic/catabolic inactivation of prostaglandins. This inactivation process will oxidize the 15-hydroxyl group of prostaglandins and yield the corresponding 15-keto (oxo) metabolite. Prostaglandins have a critical role in the signaling pathways that are involved in reproduction (establishment of pregn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HADH2
ACADSB is a human gene that encodes short/branched chain specific acyl-CoA dehydrogenase (SBCAD), an enzyme in the acyl CoA dehydrogenase family. It can cause short/branched-chain acyl-CoA dehydrogenase deficiency. Structure The human ACADSB gene is located on chromosome 10; its exact localization has been identified as 10q25-q26. The open reading frame (ORF) encodes a precursor protein that contains 431 amino acids; post-translational processing results in a mature protein with 399 amino acids. The cDNA is significantly similar to the cDNA of other members of the acyl-CoA dehydrogenase family; its structure is closest to that of short chain acyl-CoA dehydrogenase. The structure of the catalytic pocket has also been studied; position 104 at the bottom of the substrate-binding pocket has been identified as important in determining the length of the primary carbon chain that can be accommodated. Altering residues at positions 105 and 177 have been demonstrated to affect the rate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FVT1
3-dehydrosphinganine reductase () also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the ''KDSR'' gene. Function 3-dehydrosphinganine reductase catalyzes the chemical reaction: :sphinganine + NADP+ \rightleftharpoons 3-dehydrosphinganine + NADPH + H+ Thus, the two substrates of this enzyme are sphinganine and NADP+, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in sphingolipid metabolism. Tissue distribution Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue. Clinical significance FVT1 shows a high rate of transcription in some T cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Acid Synthase
Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the ''FASN'' gene. Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which Substrate (biochemistry), substrates are handed from one functional domain to the next. Its main function is to catalyze the synthesis of palmitic acid, palmitate (C16:0, a long-chain Saturated fat, saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of nicotinamide adenine dinucleotide phosphate, NADPH. The fatty acids are synthesized by a series of decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA. Following each round of elongation the beta keto group is reduced to the fully saturated carbon chain by the sequential action of a Beta-Ketoacyl ACP reductase, ketoreductase (KR), dehydratase (DH), and Enoyl-acyl carrier protein reductase, e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DHRSX
Dehydrogenase/reductase (SDR family) X-linked also known as DHRSX is an enzyme which in humans is encoded by the pseudoautosomal ''DHRSX'' gene. DHRSX is a member of the short-chain dehydrogenase family of oxidoreductase enzymes. DHRSX is required for two steps in the biosynthesis of dolichol: i) the NAD+-dependent conversion of polyprenol to its aldehyde analogue, polyprenal; ii) the NADPH-dependent reduction of dolichal to dolichol. Dolichol is a long polyisoprenoid lipid required as the carrier of mono- and oligosaccharides in the processes of N-glycosylation ''N''-linked glycosylation is the attachment of an oligosaccharide, a carbohydrate consisting of several sugar molecules, sometimes also referred to as glycan, to a nitrogen atom (the amide nitrogen of an asparagine (Asn) residue of a protein), i ..., C-/O-mannosylation and the formation of glycosylphosphatidylinositol (GPI) anchors. References Further reading * * * {{gene-X-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DHRS9
Dehydrogenase/reductase SDR family member 9 is an enzyme that in humans is encoded by the ''DHRS9'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... References Further reading * * * * * * * * External links * * {{gene-2-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DHRS7B
Dehydrogenase/reductase (SDR family) member 7B is an enzyme encoded by the DHRS7B gene in humans, found on chromosome 17p11.2. DHRS7B encodes a protein that is predicted to function in steroid hormone regulation. A deletion in the chromosomal region 17p11.2 has been associated with Smith-Magenis Syndrome, a genetic developmental disorder. Gene Overview The DHRS7B gene is located on the positive strand of chromosome 17, beginning at position 21030258 and ending at position 21094836 (64579 bp). DHRS7B contains seven exons with no predicted alternate splice forms, resulting in an 1841 bp mRNA product. Upstream of DHRS7B on the negative strand of chromosome 17p11.2 are the genes ''Coiled-coil domain containing 144 family, N-terminal-like'' ( CCDC144NL) and ''Ubiquitin specific peptidase 22'' (USP22). Downstream of DHSRS7B on the negative strand of chromosome 17p11.2 is the gene ''Transmembrane protein 11'' ( TMEM11), and on the positive strand is the gene ''Mitogen-activated pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DHRS7 (gene)
Dehydrogenase/reductase (SDR family) member 7 is a protein that in humans is encoded by the DHRS7 gene. Function Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter mem .... References Further reading * * * * * * * Human proteins {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
