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Rovalpituzumab Tesirine
Rovalpituzumab tesirine (Rova-T) is an experimental antibody-drug conjugate targeting the protein DLL3 on tumor cells. It was originally developed by Stemcentrx and was purchased by AbbVie. It was tested for use in small-cell lung cancer, but development was terminated after unsuccessful Phases of clinical research#Phase III, phase III trial. Development In 2018, an Independent Data Monitoring Committee found that in the TAHOE phase III trial, Rova-T shortened survival of lung cancer patients compared to SOC chemotherapy topotecan, prompting termination of trial enrollment. Another phase III trial (MERU) demonstrated no survival benefit over placebo. A phase II trial using the drug as a third-line treatment for relapsed or refractory lung cancer showed objective response rate at just 16%. Chemical structure Chemical structure of "tesirine" (drawn in black). It consists of a pyrrolobenzodiazepine type dimer (chemistry), dimer (top), which is the actual anti-cancer agent, a Valin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DLL3
Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the ''DLL3'' gene. Two transcript variants encoding distinct isoforms have been identified for this gene. Function This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Expression of DLL3 is highest in fetal brain. It plays a key role in somitogenesis within the paraxial mesoderm. Clinical significance Mutations in this gene cause the autosomal recessive genetic disorder Jarcho-Levin syndrome. Expression of the gene occurs in Neuroendocrine tumors, which has been targeted as a potential pathway for treatment. Experimental drugs targetting DLL3 have been investigated as a possible treatment for lung cancer including Tarlatamab Tarlatamab, sold under the brand name Imdelltra, is an anti-cancer medication used for the treatment of extensive-stage small ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
