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Preregistration
Preregistration is the practice of registering the hypotheses, methods, and/or analyses of a scientific study before it is conducted. This can include analyzing primary data or secondary data. Clinical trial registration is similar, although it may not require the registration of a study's analysis protocol. Finally, registered reports include the peer review and in principle acceptance of a study protocol prior to data collection. Preregistration assists in the identification and/or reduction of a variety of potentially problematic research practices, including p-hacking, publication bias, data dredging, inappropriate forms of post hoc analysis, and (relatedly) HARKing. It has recently gained prominence in the open science community as a potential solution to some of the issues that are thought to underlie the replication crisis. However, critics have argued that it may not be necessary when other open science practices are implemented such as Registered Reports. Types Sta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HARKing
HARKing (hypothesizing after the results are known) is an acronym coined by social psychologist Norbert Kerr that refers to the questionable research practice of “presenting a post hoc hypothesis in the introduction of a research report as if it were an a priori hypothesis”. Hence, a key characteristic of HARKing is that post hoc hypothesizing is falsely portrayed as a priori hypothesizing. HARKing may occur when a researcher tests an a priori hypothesis but then omits that hypothesis from their research report after they find out the results of their test; inappropriate forms of post hoc analysis and/or post hoc theorizing then may lead to a post hoc hypothesis. Types Several types of HARKing have been distinguished, including: ;THARKing: Transparently hypothesizing after the results are known, rather than the secretive, undisclosed, HARKing that was first proposed by Kerr (1998). In this case, researchers openly declare that they developed their hypotheses after they obse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Study Registry
Animal Study Registry is an online registry for the preregistration of research studies involving animals. Animal Study Registry was launched in January 2019 and can be used by scientists worldwide. History The reproducibility of animal test results in biomedical research has been questioned repeatedly in the past. Discussions about this replication crisis have already reached the public. In clinical research, the call for transparency led to the introduction of clinical trial registries that disclose the experimental design of clinical trials before the study is conducted. In order to increase the transparency and the quality in the field of preclinical and basic research, the establishment of so-called centralized animal study registries was suggested. The German Federal Institute for Risk Assessment (BfR), as a scientifically independent research institution, has decided to provide an international freely accessible platform for the pre-registration of studies involving anima ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication Crisis
The replication crisis (also called the replicability crisis and the reproducibility crisis) is an ongoing methodological crisis in which the results of many scientific studies are difficult or impossible to reproduce. Because the reproducibility of empirical results is an essential part of the scientific method, such failures undermine the credibility of theories building on them and potentially call into question substantial parts of scientific knowledge. The replication crisis is frequently discussed in relation to psychology and medicine, where considerable efforts have been undertaken to reinvestigate classic results, to determine both their reliability and, if found unreliable, the reasons for the failure. Data strongly indicate that other natural, and social sciences are affected as well. The phrase ''replication crisis'' was coined in the early 2010s as part of a growing awareness of the problem. Considerations of causes and remedies have given rise to a new scientifi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trial Transparency 2017
Clinical may refer to: Healthcare * Of or about a clinic, a healthcare facility * Of or about the practice of medicine Other uses * ''Clinical'' (film), a 2017 American horror thriller See also * * * Clinical chemistry, the analysis of bodily fluids for diagnostic and therapeutic purposes * Clinical death, the cessation of blood circulation and breathing * Clinical formulation, a theoretically-based explanation of information obtained from clinical assessment * Clinical governance, a systematic approach to maintaining and improving the quality of patient care * Clinical linguistics, linguistics applied to speech-language pathology * Clinical psychology, the understanding, preventing, and relieving psychologically-based distress or dysfunction * Clinical research, to determine the safety and effectiveness of medications etc. * Clinical significance, the practical importance of a treatment effect * Clinical trial, experiments or observations done in clinical research * Clinical wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Committee Of Medical Journal Editors
The ICMJE recommendations (full title, "Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals") are a set of guidelines produced by the International Committee of Medical Journal Editors for standardising the ethics, preparation and formatting of manuscripts submitted to biomedical journals for publication. Compliance with the ICMJE recommendations is required by most leading biomedical journals. Levels of real compliance are subject to debate. As of 9 January 2020, 5570 journals worldwide claim to follow the ICMJE recommendations.International Committee of Medical Journal Editors. Journals that have Requested Inclusion on the List of Publications that follow the ICMJE's Uniform Requirements For Manuscripts Submitted to Biomedical Journals omepage on the Internet Philadelphia: ICMJE; c2005 pdated 27 May 2006; cited 30 May 2006 Available fromhttp://www.icmje.org/journals.html/ref> The recommendations were first issued in 1979 un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration Amendments Act Of 2007
President of the United States George W. Bush signed the Food and Drug Administration Amendments Act of 2007 (FDAAA) on September 27, 2007. This law reviewed, expanded, and reaffirmed several existing pieces of legislation regulating the FDA. These changes allow the FDA to perform more comprehensive reviews of potential new drugs and devices. It was sponsored by Reps. Joe Barton and Frank Pallone and passed unanimously by the Senate. The FDAAA extended the authority to levy fees to companies applying for approval of drugs, expanded clinical trial guidelines for pediatric drugs, and created the priority review voucher program, amongst other items. Title I: Prescription Drug User Fee Amendments of 2007 Title I amends the Federal Food, Drug, and Cosmetic Act to include post-marketing safety activities in the review of drug application. This included developing and using improved adverse event data collection systems and improved analytical tools to assess potential safety pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uniform Requirements For Manuscripts Submitted To Biomedical Journals
The ICMJE recommendations (full title, "Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals") are a set of guidelines produced by the International Committee of Medical Journal Editors for standardising the ethics, preparation and formatting of manuscripts submitted to biomedical journals for publication. Compliance with the ICMJE recommendations is required by most leading biomedical journals. Levels of real compliance are subject to debate. As of 9 January 2020, 5570 journals worldwide claim to follow the ICMJE recommendations.International Committee of Medical Journal Editors. Journals that have Requested Inclusion on the List of Publications that follow the ICMJE's Uniform Requirements For Manuscripts Submitted to Biomedical Journals omepage on the Internet Philadelphia: ICMJE; c2005 pdated 27 May 2006; cited 30 May 2006 Available fromhttp://www.icmje.org/journals.html/ref> The recommendations were first issued in 1979 un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Declaration Of Helsinki
The Declaration of Helsinki (DoH, fi, Helsingin julistus, sv, Helsingforsdeklarationen) is a set of ethical principles regarding human experimentation developed originally in 1964 for the medical community by the World Medical Association (WMA). It is widely regarded as the cornerstone document on human research ethics. It is not a legally binding instrument under the international law, but instead draws its authority from the degree to which it has been codified in, or influenced, national or regional legislation and regulations. Its role was described by a Brazilian forum in 2000 in these words: "Even though the Declaration of Helsinki is the responsibility of the World Medical Association, the document should be considered the property of all humanity." Principles The Declaration is morally binding on physicians, and that obligation overrides any national or local laws or regulations, if the Declaration provides for a higher standard of protection of humans than the latte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Editor-in-chief
An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies. The highest-ranking editor of a publication may also be titled editor, managing editor, or executive editor, but where these titles are held while someone else is editor-in-chief, the editor-in-chief outranks the others. Description The editor-in-chief heads all departments of the organization and is held accountable for delegating tasks to staff members and managing them. The term is often used at newspapers, magazines, yearbooks, and television news programs. The editor-in-chief is commonly the link between the publisher or proprietor and the editorial staff. The term is also applied to academic journals, where the editor-in-chief gives the ultimate decision whether a submitted manuscript will be published. This decision is made by the editor-in-chief after seeking input from reviewers selected on the basis o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychological Science (journal)
''Psychological Science'', the flagship journal of the Association for Psychological Science (APS), is a monthly, peer-reviewed, scientific journal published by SAGE Publications. Publication scope ''Psychological Science'' publishes research reports and short commentaries. The journal publishes cutting-edge research articles, short reports, and research reports spanning the entire spectrum of the science of psychology. ''Psychological Science'' is a general-interest journal that publishes articles with a general theoretical significance and broad interest across the field of psychological science. The articles include topics from cognitive, social, developmental and health psychology, as well as behavioral neuroscience and biopsychology. The journal also publishes studies that employ novel research methodologies and innovative analysis techniques. Its editor is Patricia Bauer from Emory University, Atlanta, Georgia. Characteristics Published monthly, the journal appears online ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eliot Spitzer
Eliot Laurence Spitzer (born June 10, 1959) is an American politician and attorney. A member of the Democratic Party, he was the 54th governor of New York from 2007 until his resignation in 2008. Spitzer was born in New York City, attended Princeton University, and earned his law degree from Harvard. He began his career as an attorney in private practice with New York law firms before becoming a prosecutor with the office of the New York County (Manhattan) District Attorney. From 1999 to 2006, he was the Attorney General of New York, earning a reputation as the "Sheriff of Wall Street" for his efforts to curb corruption in the financial services industry. Spitzer was elected Governor of New York in 2006 by the largest margin of any candidate, but his tenure lasted less than two years after it was uncovered he patronized a prostitution ring. He resigned immediately following the scandal, and his lieutenant governor, David Paterson, served the rest of his term. Since leaving ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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