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Oxyphenbutazone
Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID). It is a metabolite of phenylbutazone. It was withdrawn from markets worldwide in mid-1980s due to bone marrow suppression and the risk of Stevens–Johnson syndrome. In ''Scrabble'', the word "oxyphenbutazone" is the highest-scoring word possible resulting in 1,780 points based on the NASPA word list of 2006. However, according to ''Mental Floss ''Mental Floss'' (stylized as ''mental_floss'') is an American online magazine and digital, print, and e-commerce media company focused on millennials. It is owned by Minute Media, an international digital media publisher based in London, Engla ...'', there is no documentation that the word "oxyphenbutazone" has ever been successfully played on a ''Scrabble'' board, and it "probably never will be". References Nonsteroidal anti-inflammatory drugs Pyrazolidindiones 4-Hydroxyphenyl compounds Scrabble Withdrawn drugs {{musculoskeletal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenylbutazone
Phenylbutazone, often referred to as "bute", is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals. In the United States and United Kingdom, it is no longer approved for human use (except in the United Kingdom for ankylosing spondylitis), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal. Positive phenylbutazone tests in horse meat were uncommon in the UK, however. Uses In humans Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, it is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable. In horses Phenylbutazone is the most commonly used NSAID for horses in the United States.McIlwraith C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scrabble
''Scrabble'' is a word game in which two to four players score points by placing tiles, each bearing a single letter, onto a Board game, game board divided into a 15×15 grid of squares. The tiles must form words that, in crossword fashion, read left to right in rows or downward in columns and are included in a standard dictionary or lexicon. American architect Alfred Mosher Butts invented the game in 1931. ''Scrabble'' is produced in the United States and Canada by Hasbro, under the brands of both of its subsidiaries, Milton Bradley Company, Milton Bradley and Parker Brothers. Mattel owns the rights to manufacture ''Scrabble'' outside the U.S. and Canada. As of 2008, the game is sold in 121 countries and is available in more than 30 languages; approximately 150 million sets have been sold worldwide, and roughly one-third of American homes and half of British homes have a ''Scrabble'' set. There are approximately 4,000 ''Scrabble'' clubs around the world. Equipment ''Scrabble ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Racemic Mixture
In chemistry, a racemic mixture or racemate () is a mixture that has equal amounts (50:50) of left- and right-handed enantiomers of a chiral molecule or salt. Racemic mixtures are rare in nature, but many compounds are produced industrially as racemates. History The first known racemic mixture was racemic acid, which Louis Pasteur found to be a mixture of the two enantiomeric isomers of tartaric acid. He manually separated the crystals of a mixture, starting from an aqueous solution of the sodium ammonium salt of racemate tartaric acid. Pasteur benefited from the fact that ammonium tartrate salt gives enantiomeric crystals with distinct crystal forms (at 77 °F). Reasoning from the macroscopic scale down to the molecular, he reckoned that the molecules had to have non-superimposable mirror images. A sample with only a single enantiomer is an ''enantiomerically pure'' or ''enantiopure'' compound. Etymology The word ''racemic'' derives from Latin , meaning pertaining to a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonsteroidal Anti-inflammatory Drug
Non-steroidal anti-inflammatory drugs (NSAID) are members of a Indication (medicine), therapeutic drug class which Analgesic, reduces pain, Anti-inflammatory, decreases inflammation, Antipyretic, decreases fever, and Antithrombotic, prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of Stomach ulcers, gastrointestinal ulcers and bleeds, heart attack, and kidney disease. The term ''non-steroidal'', common from around 1960, distinguishes these drugs from corticosteroids, another class of anti-inflammatory drugs, which during the 1950s had acquired a bad reputation due to overuse and side-effect problems after their introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isozyme, isoenzymes). In cells, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandins, which are involved in inflammation, and thromboxanes, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism. The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene exemplifies a primary metabolite produced large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin, which is created from the primary metabolite tryptophan. Some sugars are metabolites, such as fructose or glucose, which ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stevens–Johnson Syndrome
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction. Together with toxic epidermal necrolysis (TEN) and #Classification, Stevens–Johnson/toxic epidermal necrolysis (SJS/TEN) overlap, they are considered febrile mucocutaneous drug reactions and probably part of the same spectrum of disease, with SJS being less severe. Erythema multiforme (EM) is generally considered a separate condition. Early symptoms of SJS include fever and flu-like symptoms. A few days later, the skin begins to blister and peel, forming painful raw areas. Mucous membranes, such as the mouth, are also typically involved. Complications include dehydration, sepsis, pneumonia and multiple organ failure. The most common cause is certain medications such as lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotics and nevirapine. Other causes can include infections such as ''Mycoplasma pneumoniae'' and cytomegalovirus, or the cause may remain unknown. Risk factors include HIV/AIDS and syste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NASPA Word List
NASPA Word List (NWL, formerly Official Tournament and Club Word List, referred to as OTCWL, OWL, TWL) is the official word authority for tournament Scrabble in the USA and Canada under the aegis of NASPA Games. It is based on the ''Official Scrabble Players Dictionary'' (OSPD) with modifications to make it more suitable for tournament play. Its British and international-English counterpart is ''Collins Scrabble Words''. Current edition North American tournament Scrabble currently uses the sixth edition of NWL, officially called NWL2023. The NASPA Games Dictionary Committee created this version in mid-2023 and it took effect on February 29, 2024; it is the third version published autonomously by NASPA rather than by Merriam-Webster under its copyright. NWL2023 contains every word in the seventh edition of the ''Official Scrabble Players Dictionary'' as well as words considered unsuitable for that book (offensive words and trademarks). It also contains words of nine or more letters ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mental Floss
''Mental Floss'' (stylized as ''mental_floss'') is an American online magazine and digital, print, and e-commerce media company focused on millennials. It is owned by Minute Media, an international digital media publisher based in London, England, with an associated research and development center in Tel Aviv, Israel. It is based in New York City, United States. mentalfloss.com, which presents facts, puzzles, and trivia with a humorous tone, draws 20.5 million unique users a month. Its YouTube channel produces three weekly series and has 1.3 million subscribers. In October 2015, ''Mental Floss'' teamed with the National Geographic Channel for its first televised special, ''Brain Surgery Live with'' mental_floss, the first brain surgery ever broadcast live. Launched in Birmingham, Alabama in 2001, the company has additional offices in Midtown Manhattan. The publication was included in ''Inc.'' magazine's list of the 5,000 fastest growing private companies. Before it became a w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonsteroidal Anti-inflammatory Drugs
A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative. Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents. List of nonsteroidal steroid receptor modulators Examples include the following: * Estrogens: benzestrol, bifluranol, estrobin, estrobin (DBE), diethylstilbestrol, diethylstilbestrol (stilbestrol), dienestrol, erteberel, fosfestrol, hexestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens * : acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, tamoxifen, toremifene, trioxifene, zind ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
