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Mixed Cuprates
A Gilman reagent is a lithium and copper (organocopper compound, diorganocopper) reagent compound, R2CuLi, where R is an alkyl or aryl. These reagents are useful because, unlike related Grignard reagents and organolithium reagents, they react with Organic halide, organic halides to replace the halides, halide group with an R group (the Corey–House synthesis, Corey–House reaction). Such displacement reactions allow for the synthesis of complex products from simple building blocks. Reactions These reagents were discovered by Henry Gilman and coworkers. Lithium dimethylcopper (CH3)2CuLi can be prepared by adding copper(I) iodide to methyllithium in tetrahydrofuran at −78 °C. In the reaction depicted below, the Gilman reagent is a methylating reagent reacting with an alkyne in a conjugate addition, and the negative charge is trapped in a nucleophilic acyl substitution with the ester group forming a cyclic Alpha-beta Unsaturated carbonyl compounds, enone. Due to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gilman Reagent2
Gilman may refer to: Places United States *Gilman Ranch, California * Gilman, Colorado *Gilman, Illinois *Gilman, Iowa * Gilman, Minnesota * Gilman, Montana *Gilman, Vermont * Gilman, Washington, former name of Issaquah *Gilman, Pierce County, Wisconsin * Gilman, Taylor County, Wisconsin *Gilman Lake, a lake in South Dakota *Gilmanton, New Hampshire * Gilmanton, Buffalo County, Wisconsin *Gilmanton Township, Benton County, Minnesota Other *Gilman (Yap), an administrative division of the Federated States of Micronesia *Gilman Street, a street in Central, Hong Kong Other uses *Gilman (name) *Gilman reagent, any of a group of reagents discovered by Henry Gilman *Gilman Paper Company, former paper producer ** Gilman Paper Company collection, photo archive in the Metropolitan Museum of Art *Gilman School, a private boys school in Baltimore, Maryland *924 Gilman Street The Alternative Music Foundation located at 924 Gilman Street, often referred to by its fans simply as "Gilman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
