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Muscarine
Muscarine, L-(+)-muscarine, or muscarin is a Secondary metabolite, natural product found in certain mushrooms, particularly in ''Inocybe'' and ''Clitocybe'' species, such as the deadly ''Clitocybe dealbata, C. dealbata''. Mushrooms in the genera ''Entoloma'' and ''Mycena'' have also been found to contain levels of muscarine which can be dangerous if ingested. Muscarine has been found in harmless trace amounts in the genera ''Boletus'', ''Hygrocybe'', ''Lactarius (fungus), Lactarius'' and ''Russula''. Trace concentrations of muscarine are also found in ''Amanita muscaria'', though the pharmacologically more relevant compound from this mushroom is the Z-drug-like alkaloid muscimol. ''A. muscaria'' basidiocarp, fruitbodies contain a variable dose of muscarine, usually around 0.0003% fresh weight. This is very low and toxicity symptoms occur very rarely. ''Inocybe'' and ''Clitocybe'' contain muscarine concentrations up to 1.6%. Muscarine is a selective agonist of the muscar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clitocybe Dealbata
''Clitocybe'' is a genus of mushrooms characterized by white, off-white, buff, cream, pink, or light-yellow spores, gills running down the stem, and pale white to brown or lilac coloration. They are primarily saprotrophic, decomposing forest ground litter. There are estimated to be around 300 species in the widespread genus. ''Clitocybe'' means ''sloping head''. A few members of the genus are considered edible; many others are poisonous, containing the toxin muscarine among others. Distinguishing individual species of ''Clitocybe'' is generally prohibitively difficult to non-experts, requiring the analysis of microscopic characters. Therefore, with the exception of a few charismatic and readily identified members, ''Clitocybe'' mushrooms are rarely collected for consumption. Taxonomy ''Clitocybe'' was originally proposed by Elias Fries in 1821 as a tribe in the genus ''Agaricus''. Friedrich Staude elevated it to generic status in 1857. Recent molecular work has shown the g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanita Muscaria
''Amanita muscaria'', commonly known as the fly agaric or fly amanita, is a basidiomycete fungus of the genus ''Amanita''. It is a large white-lamella (mycology), gilled, white-spotted mushroom typically featuring a bright red cap covered with distinctive white warts. It is one of the most recognizable fungi in the world. ''A.muscaria'' exhibits complex genetic diversity that suggests it is a species complex rather than a single species. It is a widely distributed mushroom native to temperate and boreal forests of the Northern Hemisphere, now also naturalized in the Southern Hemisphere, forming symbiotic relationships with various trees and spreading invasively in some regions. Its name derives from its traditional use as an insecticide. It can cause poisoning, especially in children and those seeking its hallucinogenic effects, due to psychoactive compounds like muscimol and the ibotenic acid; however, fatal poisonings are extremely rare. Boiling it reduces toxicity by removi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscarinic Acetylcholine Receptor
Muscarinic acetylcholine receptors (mAChRs) are acetylcholine receptors that form G protein-coupled receptor, G protein-coupled receptor complexes in the cell membranes of certain neurons and other Cell (biology), cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers. They are mainly found in the parasympathetic nervous system, but also have a role in the sympathetic nervous system in the control of Sweat gland, sweat glands. Muscarinic receptors are so named because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpine and Hyoscine hydrobromide, scopolamine) manipulate these two distinct receptors by acting as selective agonists or receptor antagonist, antagonists. Function acetylcholine, Ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholine
Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Acetylcholine is the neurotransmitter used at the neuromuscular junction. In other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles. This property means that drugs that affect cholinergic systems can have very dangerous effects ranging from paralysis to convulsions. Acetylcholine is also a neurotransmitter in the autonomic nervous system, both as an internal transmitter for both the sympathetic nervous system, sympathetic and the parasympathetic nervous system, and as the final product released by the parasympathetic nervous system. Acetylcholine is the primary neurotransmitter of the parasympathet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inocybe
''Inocybe'' is a genus of mushroom-forming fungi, with over 1,000 species. Its members are mycorrhizal, and some evidence shows that the high degree of speciation is due to adaptation to different trees and possibly also local habitats. Taxonomy The genus was first described as ''Agaricus'' tribe ''Inocybe'' by Swedish scholar Elias Magnus Fries in volume 1 of his work, ''Systema mycologicum'' (1821), and verified in the volume 2 of his book ''Monographia Hymenomycetum Sueciae'' in 1863. All other renaming attempts are accepted synonymous. Although originally placed in the family Cortinariaceae (later shown to be polyphyletic), phylogenetic analyses suggests that the genus is better placed as the type genus of the family Inocybaceae. Sections or subgenera Source: Two supersections are informally recognized: ''Cortinate'' supersection: The stipe is only pruinose at the apex or the upper half. The stipe base is (generally) not bulbous and a remnant of a cortina is present in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholinergic Receptor
An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Classification Like other transmembrane receptors, acetylcholine receptors are classified according to their "pharmacology," or according to their relative affinities and sensitivities to different molecules. Although all acetylcholine receptors, by definition, respond to acetylcholine, they respond to other molecules as well. * Nicotinic acetylcholine receptors (''nAChR'', also known as "ionotropic" acetylcholine receptors) are particularly responsive to nicotine. The nicotine ACh receptor is also a Na+, K+ and Ca2+ ion channel. * Muscarinic acetylcholine receptors (''mAChR'', also known as "metabotropic" acetylcholine receptors) are particularly responsive to muscarine. Nicotinic and muscarinic are two main kinds of "cholinergic" receptors. Receptor types Molecular biology has shown that the nicotinic and m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Entoloma
''Entoloma'' is a genus of fungi in the order Agaricales. Called pinkgills in English, basidiocarps (fruit bodies) are typically agaricoid (gilled mushrooms), though a minority are gasteroid. All have salmon-pink basidiospores which colour the gills at maturity and are angular ( polyhedral) under a microscope. The genus is large, with almost 2000 species worldwide. Most species are saprotrophic, but some are ectomycorrhizal, and a few are parasitic on other fungi. The type, ''Entoloma sinuatum'', is one of several ''Entoloma'' species that are poisonous, typically causing mild to severe gastrointestinal illness. Taxonomy History In 1838 the Swedish mycologist Elias Magnus Fries classified all pink-spored, gilled fungi into "tribes" or "subtribes", placing those with a '' Tricholoma''-like shape and gills attached to the stem into tribe ''Entoloma''. The small subtribe ''Leptonia'' had convex fleshy membranaceous caps, the subtribe ''Nolanea'' were slender fungi with bell-sha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycena
''Mycena'' is a genus of about 500 species of fungi. Rarely more than a few centimeters in width, the mushrooms are characterized by a small conical or bell-shaped cap and a thin fragile stem. Most are grey or brown, but a few species have brighter colours. Most have a translucent and striate cap, which rarely has an incurved margin. The gills are attached and usually have cystidia. Some species, like '' M. haematopus'', exude a latex when the stem is broken, and many species have a chlorine or radish-like odour. They produce a white spore print. The species are saprotrophic. Their edibility varies, with some members containing toxins. Taxonomy ''Mycena'' is a rich genus, considered one of the most abundant genera of mushrooms within the Agaricales and with species distributed across the world. Alexander Smith's 1947 ''Mycena'' monograph identified 232 species; the genus is now known to include about 500 species worldwide. Maas Geesteranus divided the genus into 3 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscimol
Muscimol, also known as agarin or pantherine, as well as 5-(aminomethyl)-1,2-oxazol-3-ol, is the principal psychoactive constituent of ''Amanita muscaria'' and '' Amanita pantherina''. Muscimol is an isoxazole alkaloid and a potent and selective orthosteric agonist for the GABAA receptor It displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. It is widely used to study GABAergic function in the brain. Muscimol is under investigation for its potential to treat anxiety, insomnia, and neurological disorders, though its psychoactive nature requires careful regulation. A systematic review and meta-analysis of 22 studies found that muscimol reduces neuropathic pain symptoms, with effects beginning within 15 minutes and lasting up to three hours. Muscimol was tested in small clinical trials between 1977 and 1982 for conditions like schizophrenia, Huntington’s disease, and tardive dyskinesia, but showed limited efficacy and was eventually supplanted by the re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oswald Schmiedeberg
Johann Ernst Oswald Schmiedeberg (10 October 1838 – 12 July 1921) was a Baltic German pharmacologist. In 1866 he earned his medical doctorate from the University of Dorpat with a thesis concerning the measurement of chloroform in blood, before becoming the first professor of pharmacology at the University of Strasbourg, where he remained for 46 years. In 1911, he testified in the '' United States v. Forty Barrels and Twenty Kegs of Coca-Cola'' trial, and later, was a major factor in the success of the German pharmaceutical industry prior to the Second World War, having trained most of the European professors at the time. Early life and family Oswald Schmiedeberg was born in Courland, one of the Baltic provinces of Russia. His father Wilhelm Ludwig (1809–1878) was a bailiff in Leidzen and later forester in Paggar (Estonia). His mother Anna Lucie Bernard (1813–1871) was the daughter of a watchmaker from Lausanne. Oswald was the eldest of six siblings of whom a brother Johann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parasympathomimetic
A parasympathomimetic drug, sometimes called a cholinomimetic drug or cholinergic receptor stimulating agent, is a substance that stimulates the parasympathetic nervous system (PSNS). These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS. Chemicals in this family can act either directly by stimulating the nicotinic or muscarinic receptors (thus mimicking acetylcholine), or indirectly by inhibiting cholinesterase, promoting acetylcholine release, or other mechanisms. Common uses of parasympathomimetics include glaucoma, Sjögren syndrome and underactive bladder. Some chemical weapons such as sarin or VX, non-lethal riot control agents such as tear gas, and insecticides such as diazinon fall into this category. Structure activity relationships for parasympathomimetic drugs For a cholinergic agent, the following criteria describe the structure activity relationship: # Ing's Rule of 5: there should be no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
