Lipoylation
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA under physiological conditions. Only the (''R'')-(+)-enantiomer (RLA) exists in nature and is essential for aerobic metabolism because RLA is an essential Cofactor (biochemistry), cofactor of many enzyme complexes. Physical and chemical properties Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA), and thioctic acid is an organosulfur compound derived from caprylic acid, octanoic acid. LA contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and i ...
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The Journal Of Clinical Pharmacology
''The Journal of Clinical Pharmacology'' is a peer-reviewed medical journal that covers the field of pharmacology. The editor-in-chief is Joseph S. Bertino, Jr. ( Bertino Consulting). It was established in 1961 and is currently published by John Wiley & Sons in association with the American College of Clinical Pharmacology. Title history The journal was founded in 1961 as ''The Journal of New Drugs''. It was known from 1967 to 1970 as ''The Journal of Clinical Pharmacology and the Journal of New Drugs'' and from 1970 to 1973 as ''The Journal of Clinical Pharmacology and New Drugs''. In 1973 it obtained its present title. Abstracting and indexing ''The Journal of Clinical Pharmacology'' is abstracted and indexed An abstracting service is a service that provides abstracts of publications, often on a subject or group of related subjects, usually on a subscription basis. An indexing service is a service that assigns descriptors and other kinds of access poi ... in the following b ...
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