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Follicular Hyperkeratosis
Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis, or skin), often associated with the presence of an abnormal quantity of keratin,Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) ''Robbins & Cotran Pathologic Basis of Disease'' (7th ed.). Saunders. Page 1230. . and is usually accompanied by an increase in the granular layer. As the corneum layer normally varies greatly in thickness in different sites, some experience is needed to assess minor degrees of hyperkeratosis. It can be caused by vitamin A deficiency or chronic exposure to arsenic. Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as vemurafenib and dabrafenib.Niezgoda, Anna; Niezgoda, Piotr; Czajkowski, Rafal (2015) ''Novel Approaches to Treatment of Advanced Melanoma: A Review of Targeted Therapy and Immunotherapy'' BioMed Research International It can be treated with urea-containing creams, which dissolve the intercellular matrix of the cells of the stratum corne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micrograph
A micrograph is an image, captured photographically or digitally, taken through a microscope or similar device to show a magnify, magnified image of an object. This is opposed to a macrograph or photomacrograph, an image which is also taken on a microscope but is only slightly magnified, usually less than 10 times. Micrography is the practice or art of using microscopes to make photographs. A photographic micrograph is a photomicrograph, and one taken with an electron microscope is an electron micrograph. A micrograph contains extensive details of microstructure. A wealth of information can be obtained from a simple micrograph like behavior of the material under different conditions, the phases found in the system, failure analysis, grain size estimation, elemental analysis and so on. Micrographs are widely used in all fields of microscopy. Types Photomicrograph A light micrograph or photomicrograph is a micrograph prepared using an optical microscope, a process referred to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hair Follicle
The hair follicle is an organ found in mammalian skin. It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction between hormones, neuropeptides, and immune cells. This complex interaction induces the hair follicle to produce different types of hair as seen on different parts of the body. For example, terminal hairs grow on the scalp and lanugo hairs are seen covering the bodies of fetuses in the uterus and in some newborn babies. The process of hair growth occurs in distinct sequential stages: ''anagen'' is the active growth phase, ''catagen'' is the regression of the hair follicle phase, ''telogen'' is the resting stage, ''exogen'' is the active shedding of hair phase and ''kenogen'' is the phase between the empty hair follicle and the growth of new hair. The function of hair in humans has long been a subject of interest and continues to be an impor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis-Anne-Jean Brocq
Louis-Anne-Jean Brocq (; 1 February 1856 – 18 December 1928) was a French dermatologist born in Laroque-Timbaut, a village in the department of Lot-et-Garonne. He practiced medicine in Paris at the Hospice la Rochefoucauld, the Hôpital Broca, and from 1906 to 1921, the Hôpital Saint-Louis. As a young physician he studied and worked with Jean Alfred Fournier (1832–1915), Jean Baptiste Emile Vidal (1825–1893) and Ernest Henri Besnier (1831–1909). Brocq provided early, comprehensive descriptions of numerous skin disorders, including keratosis pilaris, parapsoriasis and a form of dermatitis called "Duhring-Brocq disease" (named with Louis Adolphus Duhring and sometimes referred to as dermatitis herpetiformis). Other eponymous skin diseases named after him are " Brocq's pseudopelade", a condition involving progressive scarring of the scalp, and "Brocq-Pautrier angiolupoid", a specific type of sarcoidosis of the skin named in conjunction with Dr. Lucien-Marie Pautrier (18 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidermolytic Hyperkeratosis
Epidermolytic ichthyosis (EI), is a severe form of dry scaly skin, that initially presents with redness, blisters, erosions, and peeling in a newborn baby. Hyperkeratosis typically develops several months later. Other symptoms include itch, painful fissures, strong body odor, and absence of sweat. Symptoms vary in severity and extent of skin involvement. The two main types are divided into one involving palms and soles and the other without. EI is caused by a genetic mutation. The condition involves the clumping of keratin filaments. The condition is rare, affecting around 1 in 200,000 to 300,000 babies. Signs and symptoms EI is a severe form of dry scaly skin, that initially presents with redness, blisters, erosions, and peeling in a newborn baby. Hyperkeratosis typically develops several months later. Other symptoms include itch, painful fissures, body odor, and absence of sweat. Symptoms vary in severity and extent of skin involvement. Complications include infecti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Foot
The foot (: feet) is an anatomical structure found in many vertebrates. It is the terminal portion of a limb which bears weight and allows locomotion. In many animals with feet, the foot is an organ at the terminal part of the leg made up of one or more segments or bones, generally including claws and/or nails. Etymology The word "foot", in the sense of meaning the "terminal part of the leg of a vertebrate animal" comes from Old English ''fot'', from Proto-Germanic *''fot'' (source also of Old Frisian ''fot'', Old Saxon ''fot'', Old Norse ''fotr'', Danish ''fod'', Swedish ''fot'', Dutch ''voet'', Old High German ''fuoz'', German ''Fuß'', Gothic ''fotus'', all meaning "foot"), from PIE root *''ped-'' "foot". The plural form ''feet'' is an instance of i-mutation. Structure The human foot is a strong and complex mechanical structure containing 26 bones, 33 joints (20 of which are actively articulated), and more than a hundred muscles, tendons, and ligaments.Podiatry Chan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sole (foot)
In humans, the sole of the foot is anatomically referred to as the plantar aspect. Structure The glabrous skin on the sole of the foot lacks the hair and pigmentation found elsewhere on the body, and it has a high concentration of sweat pores. The sole contains the thickest layers of skin on the body due to the weight that is continually placed on it. It is crossed by a set of creases that form during the early stages of embryonic development. Like those of the palm, the sweat pores of the sole lack sebaceous glands. The sole is a sensory organ by which the ground can be perceived while standing and walking. The subcutaneous tissue in the sole has adapted to deal with the high local compressive forces on the heel and the ball (between the toes and the arch) by developing a system of "pressure chambers." Each chamber is composed of internal fibrofatty tissue covered by external collagen connective tissue. The septa (internal walls) of these chambers are permeated by n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bethlem Myopathy
Bethlem myopathy is predominantly an autosomal dominant myopathy, classified as a congenital form of limb-girdle muscular dystrophy. There are two types of Bethlem myopathy, based on which type of collagen is affected. Bethlem myopathy 1 (BTHLM1) is caused by a mutation in one of the three genes coding for type VI collagen. These include COL6A1, COL6A2, and COL6A3. It is typically autosomal dominant, though uncommonly can be autosomal recessive. Bethlem myopathy 2 (BTHLM2), formerly known as myopathic-type Ehlers–Danlos syndrome, is caused by a mutation on the COL12A1 gene coding for type XII collagen. It is autosomal dominant. In 2017, an international workshop proposed a redefined criteria and naming system for limb-girdle muscular dystrophies. Bethlem myopathy 1 (collagen VI) was included into the proposed list and renamed LGMDD5 for autosomal dominant mutations and LGMDR22 for recessive mutations. Bethlem myopathy 2 (collagen XII) was not addressed. Gowers's sign, to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
B Vitamins
B vitamins are a class of water-soluble vitamins that play important roles in Cell (biology), cell metabolism and synthesis of red blood cells. They are a chemically diverse class of compounds. Dietary supplements containing all eight are referred to as a vitamin B complex. Individual B vitamins are referred to by B-number or by chemical name, such as B1 for thiamine, B2 for riboflavin, and B3 for niacin, while some are more commonly recognized by name than by number, such as pantothenic acid (B5), biotin (B7), and folate (B9). B vitamins are present in protein (nutrient), protein-rich foods, such as Fish as food, fish, poultry, meat, dairy products, and Eggs as food, eggs; they are also found in Leaf vegetable, leafy green vegetables, beans, and peas. food fortification, Fortified foods, such as breakfast cereals, baked products, and infant formulas, may contain B vitamins. Each B vitamin is either a cofactor (biochemistry), cofactor (generally a cofactor (biochemistry), coenzym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Journal Of Nutrition
The ''British Journal of Nutrition'' is a peer-reviewed scientific journal covering research on animal and human nutrition. It was established in 1947 and is published by Cambridge University Press on behalf of The Nutrition Society. The editor-in-chief is Professor John Mathers of Newcastle University. According to the ''Journal Citation Reports'', the journal has a 2022 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.6. References External links * The Nutrition Society English-language journals Cambridge University Press academic journals Nutrition and dietetics journals Nutrition in the United Kingdom Biweekly journals Academic journals established in 1947 Academic journals associated with learned and professional societies of the United Kingd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin E Deficiency
Vitamin E deficiency is a rare condition caused by low levels of vitamin E that may result from malabsorption disorders (such as abetalipoproteinemia, cystic fibrosis, or Crohn's disease), or impaired lipid transport. As a potent antioxidant, vitamin E protects cell membranes from oxidative damage, and its deficiency primarily affects tissues with high fatty acid content, especially the nervous system. Clinically, patients may present with spinocerebellar ataxia, polyneuropathy, muscle weakness, and retinopathy. Diagnosis is confirmed through low serum vitamin E levels, and treatment involves dietary supplementation with vitamin E and (if possible) addressing the underlying cause of malabsorption. The term 'vitamin E' commonly refers to α-tocopherol, and so α-tocopherol deficiency refers to the same syndrome. Signs and symptoms Vitamin E deficiency is typically seen only in the setting of severe and prolonged illnesses causing steatorrhea or other forms of malabsorption. Other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avitaminosis
Vitamin deficiency is the condition of a long-term lack of a vitamin. When caused by not enough vitamin intake it is classified as a ''primary deficiency'', whereas when due to an underlying disorder such as malabsorption it is called a ''secondary deficiency''. An underlying disorder can have 2 main causes: * Metabolic causes: Genetic defects in enzymes (e.g. kynureninase) involved in the kynurenine pathway of synthesis of niacin from tryptophan can lead to pellagra (niacin deficiency). * Lifestyle choices: Lifestyle choices and habits that increase vitamin needs, such as smoking or drinking alcohol. Government guidelines on vitamin deficiencies advise certain intakes for healthy people, with specific values for women, men, babies, children, the elderly, and during pregnancy or breastfeeding. Many countries have mandated vitamin food fortification programs to prevent commonly occurring vitamin deficiencies. Conversely, hypervitaminosis refers to symptoms caused by vitamin i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
