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Chondrogenesis
Chondrogenesis is the process by which cartilage is developed. Cartilage in fetal development In embryogenesis, the skeletal system is derived from the mesoderm germ layer. Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondrocytes and begins secreting the molecules that form the extracellular matrix. Early in fetal development, the greater part of the skeleton is cartilaginous. This ''temporary'' cartilage is gradually replaced by bone ( Endochondral ossification), a process that ends at puberty. In contrast, the cartilage in the joints remains unossified during the whole of life and is, therefore, ''permanent''. Mineralization Adult hyaline articular cartilage is progressively mineralized at the junction between cartilage and bone. It is then termed ''articular calcified cartilage''. A mineralization front advances through the base of the hyaline articular cartilage at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC26A2
The sulfate transporter is a solute carrier family protein that in humans is encoded by the ''SLC26A2'' gene. SLC26A2 is also called the diastrophic dysplasia sulfate transporter (DTDST), and was first described by Hästbacka et al. in 1994. A defect in sulfate activation described by Superti-Furga in achondrogenesis type 1B was subsequently also found to be caused by genetic variants in the sulfate transporter gene. This sulfate (SO42−) transporter also accepts chloride, hydroxyl ions (OH−), and oxalate as substrates. SLC26A2 is expressed at high levels in developing and mature cartilage, as well as being expressed in lung, placenta, colon, kidney, pancreas and testis. Function The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. Thi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Articular Cartilage Repair
Articular cartilage repair treatment is focused on the restoration of the surface of an articular joint's hyaline cartilage. Over the last few decades, surgeons and researchers have made progress in elaborating surgical cartilage repair interventions. Though these solutions do not perfectly ''restore'' the articular cartilage, some of the latest technologies start to bring very promising results in ''repairing'' cartilages from traumatic injuries or chondropathies. These treatments are especially targeted for patients who have articular cartilage damage. They provide pain relief, while at the same time slowing down the progression of damage or considerably delaying the joint replacement (knee replacement) surgery. Articular cartilage repair treatments helps patients to return to their original lifestyle with reduced pain, regaining mobility, going back to work, and even practicing sports again. Different articular cartilage repair procedures Though the different articular cartil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chondrocytes
Chondrocytes (, from Greek χόνδρος, ''chondros'' = cartilage + κύτος, ''kytos'' = cell) are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans. Although the word ''chondroblast'' is commonly used to describe an immature chondrocyte, the term is imprecise, since the progenitor of chondrocytes (which are mesenchymal stem cells) can differentiate into various cell types, including osteoblasts. Development From least- to terminally-differentiated, the chondrocytic lineage is: # Colony-forming unit-fibroblast # Mesenchymal stem cell / marrow stromal cell # Chondrocyte # Hypertrophic chondrocyte Mesenchymal (mesoderm origin) stem cells are undifferentiated, meaning they can differentiate into a variety of generative cells commonly known as osteochondrogenic (or osteogenic, chondrogenic, osteoprogenitor, etc.) cells. When referring to bone, or in this case cartilage, the original ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cartilage
Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck and the bronchial tubes, and the intervertebral discs. In other taxa, such as chondrichthyans, but also in cyclostomes, it may constitute a much greater proportion of the skeleton. It is not as hard and rigid as bone, but it is much stiffer and much less flexible than muscle. The matrix of cartilage is made up of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. Because of its rigidity, cartilage often serves the purpose of holding tubes open in the body. Examples include the rings of the trachea, such as the cricoid cartilage and carina. Cartilage is composed of specialized cells called chondrocytes that produce a large amount of collagenous extracellular matrix, abundant ground substance that is rich in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SOX5
Transcription factor SOX-5 is a protein that in humans is encoded by the ''SOX5'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b .... Function This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Mutations in the SOX5 gene can cause Lamb-Shaffer syndrome. See also * SOX genes References Further reading * * * * * * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NKX3-2
NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of ''bagpipe (bap)'' in ''Drosophila'' and therefore also known as Bapx1 (bagpipe homeobox homolog 1). The protein encoded by this gene is a homeodomain containing transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f .... Function NKX3-2 plays a role in the development of the axial and limb skeleton. Mutations disrupting the function of this gene are associated witspondylo-megaepiphyseal-metaphyseal dysplasia(SMMD). Nkx3-2 in mice also regulates patterning in the middle ear. Two small bones in the middle ear, the malleus and incus, are homologous to the articular and quadrate, the bones of the proximal jaw joint in fish and other non-mammalian jawed vertebrates. NKX3-2 expression is required to p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SOX6
Transcription factor SOX-6 is a protein that in humans is encoded by the ''SOX6'' gene. Function The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes. upplied by OMIMref name="entrez"/> Interactions SOX6 has been shown to interact with CTBP2 and CENPK Centromere protein K is a protein that in humans is encoded by the ''CENPK'' gene. Interactions CENPK has been shown to interact with SOX6 Transcription factor SOX-6 is a protein that in humans is encoded by the ''SOX6'' gene. Function .... It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lepisosteus Oculatus Larva At 22 Days
''Lepisosteus'' is a genus of gars in the family Lepisosteidae. Distribution While in the present day, ''Lepisosteus'' is only known across North America, fossil remains show it was much more widespread in the past, with specimens known from the Cretaceous of India and Brazil. Systematics Species The currently recognized species are: Extant species Fossil species * †''Lepisosteus aganus'' (Cope, 1877) * †''Lepisosteus bemisi'' Grande, 2010 * †''Lepisosteus bohemicus'' (Laube, 1901) * †''Lepisosteus cominatoi'' Santos, 1984 * †''Lepisosteus cycliferus'' (Cope, 1873) * †''Lepisosteus glaber'' Marsh, 1871 * †''Lepisosteus indicus'' Woodward, 1908 * †'' Lepisosteus integer'' (Cope, 1877) * †'' Lepisosteus fimbriatus'' Wood, 1846 * †'' Lepisosteus knieskerni'' Fowler, 1911 * †'' Lepisosteus longus'' Lambe, 1908 * †'' Lepisosteus nahunticus'' (Cope, 1869) * †'' Lepisosteus notabilis'' Leidy, 1873 * †'' Lepisosteus occidentalis''Pearson ''et al.'', 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parathyroid Hormone-related Protein
Parathyroid hormone-related protein (PTHrP) is a proteinaceous hormone and a member of the parathyroid hormone family secreted by mesenchymal stem cells. It is occasionally secreted by cancer cells (for example, breast cancer, certain types of lung cancer including squamous-cell lung carcinoma). However, it also has normal functions in bone, teeth, vascular tissues and other tissues. Function PTHrP acts as an endocrine, autocrine, paracrine, and intracrine hormone. It regulates endochondral bone development by maintaining the endochondral growth plate at a constant width. It also regulates epithelial–mesenchymal interactions during the formation of the mammary glands. PTHrP plays a major role in regulating calcium homeostasis in vertebrates, including sea bream, chick, and mammals. In 2005, Australian pathologist and researcher Thomas John Martin found that PTHrP produced by osteoblasts is a physiological regulator of bone formation. Martin and Miao ''et al.'' demo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indian Hedgehog
The Indian hedgehog (''Paraechinus micropus'') is a species of hedgehog native to India and Pakistan. It mainly lives in sandy desert areas but can be found in other environments. Description The Indian hedgehog can be compared to the long-eared hedgehog (''Hemiechinus auritus'') which has a similar lifestyle and appearance. It is known for its masked face, dark with a white top, somewhat similar to a raccoon. It is relatively small with the adult male weighing about 435 grams and the adult female about 312. They are quite fast, although not as fast as the long-eared hedgehog. Its color is predominantly brown with a few lighter shades of brown. The tail is only about 2-4 centimeters long. It has a stocky body with a short head, a long snout, small, dark eyes, and relatively large ears. Its legs are a gray-brown color with 5 digits on each and small but strong claws. Hedgehogs are protected species under Schedule IV of Wildlife Protection Act (1972). Indian hedgehogs also have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sox9
Transcription factor SOX-9 is a protein that in humans is encoded by the ''SOX9'' gene. Function SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It is expressed by proliferating but not hypertrophic chondrocytes that is essential for differentiation of precursor cells into chondrocytes and, with steroidogenic factor 1, regulates transcription of the anti-Müllerian hormone ( AMH) gene. SOX-9 also plays a pivotal role in male sexual development; by working with Sf1, SOX-9 can produce AMH in Sertoli cells to inhibit the creation of a female reproductive system. It also interacts with a few other genes to promote the development of male sexual organs. The process starts when the transcription factor Testis determining factor (encoded by the sex-determining region SRY of the Y chromosome) activates SOX-9 activity by binding to an enhancer sequence upstream of the gene. Next, Sox9 activates FGF9 and forms feedforward ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sonic Hedgehog
Sonic hedgehog protein (SHH) is encoded for by the ''SHH'' gene. The protein is named after the character ''Sonic the Hedgehog''. This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted. Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abnormal a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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