Transcription factor SOX-6 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''SOX6''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.
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Interactions
SOX6 has been shown to
interact
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with
CTBP2 and
CENPK
Centromere protein K is a protein that in humans is encoded by the ''CENPK'' gene.
Interactions
CENPK has been shown to interact with SOX6
Transcription factor SOX-6 is a protein that in humans is encoded by the ''SOX6'' gene.
Function
...
.
It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near ''SOX6'' transcriptional start site.
Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells. In addition, SOX6 may have a role in tumor growth of Ewing sarcoma.
A new role of Sox6 in renin and prorenin regulation was studied using a Sox KO mouse model in which Sox6 is only knockout in renin expressing cells. This study showed that renin promoter possesses the binding site for Sox6. The highlight of the study was that Sox6 is one of the key regulators of renin and prorenin regulation and JG cell expansion during low salt and dehydration in mice. PMID: 31760770; DOI: 10.1152/ajprenal.00095.2019
See also
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SOX genes
References
Further reading
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External links
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Transcription factors
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