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Butyrolactol A
Butyrolactol A is an organic chemical compound of interest for its potential use as an antifungal antibiotic. One of a number of potentially useful substances derived from the bacteria ''Streptomyces rochei'', it demonstrates broad antimicrobial activity against fungi, including ''Candida albicans''. Butyrolactol A is a polyketide featuring a Butyl group, ''tert''-butyl group linked to a long hydrophobic carbon chain followed by 8 polyol groups. Research has shown that, using isotopic labeling of media and spectroscopic techniques to identify precursor products which are eventually incorporated into the final product, it can be created via a Biosynthesis, biosynthetic pathway. Further analysis of gene clusters encoding for biosynthetic enzymes confirmed the presence of polyketide synthesizing genes that are involved with the aforementioned pathways for this molecule. Biosynthesis Acetate pathway The long carbon chain contained in Butyrolactol A was determined to originate fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces Rochei
''Streptomyces rochei'' is a bacterium species from the genus of ''Streptomyces'' which has been isolated from soil in Russia.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces rochei'' produces borrelidin, butyrolactol A, butyrolactol B, uricase and streptothricin. ''Streptomyces rochei'' has antifungal activity against ''Fusarium oxysporum'' f.sp. ''lycopersici'' and ''Aspergillus fumigatus''. ''Streptomyces rochei'' produces moenomycin and bambermycin. ''Streptomyces rochei'' produces amicetin A, amicetin B, amicetin C and streptolin. ''Streptomyces rochei'' produces endo-β-N-acetylglucosaminidase mithramycin, amicetin, bamicetin, and plicacetin. Further reading * * * * * * * * * * * * * See also * List of Streptomyces species The following is a list of ''Streptomyces'' species, organized alphabetically by species name. Names that have not been validated according to the Bacteriological Code are enclosed in "quotes". ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
