|
Zebrafish
The zebrafish (''Danio rerio'') is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a " tropical fish" although it is both tropical and subtropical). The zebrafish is an important and widely used vertebrate model organism in scientific research, particularly developmental biology, but also gene function, oncology, teratology, and drug development, in particular pre-clinical development. It is also notable for its regenerative abilities, and has been modified by researchers to produce many transgenic strains. Taxonomy The zebrafish is a derived member of the genus '' Brachydanio'', of the family Cyprinidae. It has a sister-group relationship with '' Danio aesculapii''. Zebrafish are also closely related to the genus '' Devario'', as demonstrated by a phylogenetic tree of close species. Distri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural Recombination (biology), recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms. Genetic modification can include the introduction of new genes or enhancing, altering, or Gene knockout, knocking out endogenous genes. In some genetic modifications, genes are transferred Cisgenesis, within the same species, across species (creating transgenic organisms), and even across Kingdom (biology), kingdoms. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Model Organism
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. Research using animal models has been central to most of the achievements of modern medicine. It has contributed most of the basic knowledge in fields such as human physiology and biochemistry, and has played significant roles in fields such as neuroscience and infectious disease. The results have included the near- eradication of polio and the development of organ transplantation, and have benefited both humans and animals. From 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cypriniformes
Cypriniformes is an order of ray-finned fish, which includes many families and genera of cyprinid ( carps and their kin) fish, such as barbs, loaches, botias, and minnows (among others). Cypriniformes is an "order-within-an-order", placed under the superorder Ostariophysi—which is also made up of cyprinid, ostariophysin fishes. The order contains 11–12 families (with some authorities having listed as many as 23), over 400 genera, and more than 4,250 named species; new species are regularly described, and new genera are recognized frequently.Eschmeyer, W.N., Fong, J.D. (2015Species by family/subfamilyin the Catalog of Fishes, California Academy of Sciences (retrieved 2 July 2015) Cyprinids are most diverse in South and Southeast Asia and are entirely absent from Australia and South America.Nelson (2006) At 112 years old, the longest-lived cypriniform fish documented is the bigmouth buffalo. Their closest living relatives are the Characiformes ( characins, tetras a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brachydanio
''Danio'' is a genus of small freshwater fish in the family Cyprinidae found in South and Southeast Asia, commonly kept in aquaria. They are generally characterised by a pattern of horizontal stripes, rows of spots or vertical bars. Some species have two pairs of long barbels. Species of this genus consume various small aquatic insects, crustaceans and worms. Taxonomy The name ''"danio"'' comes from the Bangla name ''dhani'', meaning "of the rice field". ''Danio'' was described in the early 19th century by Francis Hamilton. Two of the species included by him in the genus, still remain valid—''D. dangila'' and ''D. rerio''. About a century later (1916) and with many more species described in the meantime, the genus was split; the larger species into ''Danio'' and the smaller species into the genus ''Brachydanio''.Spence, R., Gerlach, G., Lawrence, C. & Smith, C. (2007)The behaviour and ecology of the zebrafish, ''Danio rerio''.''Biological Reviews'', 83 (1): 13–34. In 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regeneration (biology)
Regeneration in biology is the process of renewal, restoration, and tissue growth that makes genomes, cell (biology), cells, organisms, and ecosystems Resilience (ecology), resilient to natural fluctuations or events that cause disturbance or damage. Every species is capable of regeneration, from bacteria to humans. Regeneration can either be complete where the new tissue is the same as the lost tissue, or incomplete after which the necrotic tissue becomes Fibrosis, fibrotic. At its most elementary level, regeneration is mediated by the molecular processes of gene regulation and involves the cellular processes of cell proliferation, morphogenesis and cell differentiation. Regeneration in biology, however, mainly refers to the Morphogenesis, morphogenic processes that characterize the phenotypic plasticity of Phenotypic trait, traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. Above the genetic level, rege ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Developmental Biology
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. Perspectives The main processes involved in the embryogenesis, embryonic development of animals are: tissue patterning (via regional specification and patterned cellular differentiation, cell differentiation); tissue growth; and tissue morphogenesis. * Regional specification refers to the processes that create the spatial patterns in a ball or sheet of initially similar cells. This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyprinidae
Cyprinidae is a family of freshwater fish commonly called the carp or minnow family, including the carps, the true minnows, and their relatives the barbs and barbels, among others. Cyprinidae is the largest and most diverse fish family, and the largest vertebrate animal family overall, with about 1,780 species divided into 166 valid genera. Cyprinids range from about in size to the giant barb (''Catlocarpio siamensis''). By genus and species count, the family makes up more than two-thirds of the ostariophysian order Cypriniformes. The family name is derived from the Greek word ( 'carp'). Biology and ecology Cyprinids are stomachless, or ''agastric'', fish with toothless jaws. Even so, food can be effectively chewed by the gill rakers of the specialized last gill bow. These pharyngeal teeth allow the fish to make chewing motions against a chewing plate formed by a bony process of the skull. The pharyngeal teeth are unique to each species and are used to identify spec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transgenic
A transgene is a gene that has been transferred naturally, or by any of a number of genetic engineering techniques, from one organism to another. The introduction of a transgene, in a process known as transgenesis, has the potential to change the phenotype of an organism. ''Transgene'' describes a segment of DNA containing a gene sequence that has been isolated from one organism and is introduced into a different organism. This non-native segment of DNA may either retain the ability to produce RNA or protein in the transgenic organism or alter the normal function of the transgenic organism's genetic code. In general, the DNA is incorporated into the organism's germ line. For example, in higher vertebrates this can be accomplished by injecting the foreign DNA into the nucleus of a fertilized ovum. This technique is routinely used to introduce human disease genes or other genes of interest into strains of laboratory mice to study the function or pathology involved with that part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derived Trait
In phylogenetics, an apomorphy (or derived trait) is a novel character or character state that has evolved from its ancestral form (or plesiomorphy). A synapomorphy is an apomorphy shared by two or more taxa and is therefore hypothesized to have evolved in their most recent common ancestor. ) In cladistics, synapomorphy implies homology. Examples of apomorphy are the presence of erect gait, fur, the evolution of three middle ear bones, and mammary glands in mammals but not in other vertebrate animals such as amphibians or reptiles, which have retained their ancestral traits of a sprawling gait and lack of fur. Thus, these derived traits are also synapomorphies of mammals in general as they are not shared by other vertebrate animals. Etymology The word —coined by German entomologist Willi Hennig—is derived from the Ancient Greek words (''sún''), meaning "with, together"; (''apó''), meaning "away from"; and (''morphḗ''), meaning "shape, form". Determining ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francis Buchanan-Hamilton
Francis Buchanan (15 February 1762 – 15 June 1829), later known as Francis Hamilton but often referred to as Francis Buchanan-Hamilton, was a Scottish surgeon, surveyor and botanist who made significant contributions as a geographer and zoologist while living in India. He did not assume the name of Hamilton until three years after his retirement from India. The standard botanical author abbreviation Buch.-Ham. is applied to plants and animals he described, though today the form "Hamilton, 1822" is more usually seen in ichthyology and is preferred by Fishbase. Early life Francis Buchanan was born at Bardowie, Callander, Perthshire where Elizabeth, his mother, lived on the estate of Branziet; his father Thomas, a physician, came in Stirling, Spittal and claimed the chiefdom of the name of Clan Buchanan, Buchanan and owned the Leny estate. Francis Buchanan matriculated in 1774 and received an MA in 1779. As he had three older brothers, he had to earn a living from a profession, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process—from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials—to approved vaccine or drug typically takes more than a decade. New chemical entity development Broadly, the process of drug development can be divided into preclinical and clinical work. Pre-clinical New chemical entities (NCEs, also known as new molecular entities or NMEs) are compounds that emerge from the process of drug discovery. These h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cladistics
Cladistics ( ; from Ancient Greek 'branch') is an approach to Taxonomy (biology), biological classification in which organisms are categorized in groups ("clades") based on hypotheses of most recent common ancestry. The evidence for hypothesized relationships is typically shared derived (phylogenetics), derived characteristics (synapomorphies) that are not present in more distant groups and ancestors. However, from an empirical perspective, common ancestors are inferences based on a cladistic hypothesis of relationships of taxa whose Phenotypic trait, character states can be observed. Theoretically, a last common ancestor and all its descendants constitute a (minimal) clade. Importantly, all descendants stay in their overarching ancestral clade. For example, if the terms ''worms'' or ''fishes'' were used within a ''strict'' cladistic framework, these terms would include humans. Many of these terms are normally used Paraphyly, paraphyletically, outside of cladistics, e.g. as a 'E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
