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Tak Wah Mak
Tak Wah Mak, (; born October 4, 1946, in China) is a Canadian medical researcher, geneticist, oncologist, and biochemist. He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology. In 1995, Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment. Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for acute myeloid leukemia in August 2017, becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment. He has worked in a variety of areas including biochemistry, immunology, and cancer genetics. Early life Born in southern China in 1946 to parents who were silk merchants, and raised in Hong Kong, parents encouraged him to become a doctor, his interests lay elsewhere - in math, biology, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mai (Chinese Surname)
Mài is a Chinese surname. It is commonly transliterated as Mak in Hong Kong, based on the Cantonese pronunciation, though other transliterations exist. "麥" is the standard character in both Traditional and Simplified scripts but 麦 is also a variant seen in a both. The meaning of the Chinese character is either wheat or barley. According to a 2013 study, 麦 was the 200th most common surname, shared by 550,000 people or 0.041% of the population, with Guangdong being the province with the most. Notable people * Alan Mak, Hong Kong director * Alan Mak, British politician * Alice Mak, the Secretary for Home and Youth Affairs of Hong Kong * Alice Mak, Chinese cartoonist and creator of ''McMug''/''McDull'' * Juno Mak, Hong Kong singer * Karl Maka, (Chinese: 麥嘉) Hong Kong film producer, director, actor, and presenter. * Bow-sim Mark, (Chinese: 麥寶嬋) martial arts grandmaster, credited with popularizing the term “Wushu” outside of China, mother of martial a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agios Pharmaceuticals
Agios Pharmaceuticals Inc. is a public American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013. History In 2012, Agios was named among the defendants in a lawsuit against one of its founders, Craig Thompson, alleging that Thompson used research illegally taken from the Abramson Family Cancer Research Institute in research at Agios. In May 2016, the company announced it would launch partnership with Celgene, developing metabolic immuno-oncology therapies and licensing AG-221 as well as AG-881 to Celgene, potentially garnering Agios $120 million in drug licensing payments. In April 2017, the company raised $250 million in a new stock offering in anticipation o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cloning
Cloning is the process of producing individual organisms with identical or virtually identical DNA, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction. In the field of biotechnology, cloning is the process of creating cloned organisms (copies) of cells and of DNA fragments (molecular cloning). Etymology Coined by Herbert J. Webber, the term clone derives from the Ancient Greek word (), ''twig'', which is the process whereby a new plant is created from a twig. In botany, the term ''lusus'' was used. In horticulture, the spelling ''clon'' was used until the early twentieth century; the final ''e'' came into use to indicate the vowel is a "long o" instead of a "short o". Since the term entered the popular lexicon in a more general context, the spelling ''clone'' has been used exclusively. Natural cloning Cloning is a natural form of reproduction that has allowed life forms to spread for hundreds of millions of years. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mark M
Mark may refer to: Currency * Bosnia and Herzegovina convertible mark, the currency of Bosnia and Herzegovina * East German mark, the currency of the German Democratic Republic * Estonian mark, the currency of Estonia between 1918 and 1927 * Finnish markka ( sv, finsk mark, links=no), the currency of Finland from 1860 until 28 February 2002 * Mark (currency), a currency or unit of account in many nations * Polish mark ( pl, marka polska, links=no), the currency of the Kingdom of Poland and of the Republic of Poland between 1917 and 1924 German * Deutsche Mark, the official currency of West Germany from 1948 until 1990 and later the unified Germany from 1990 until 2002 * German gold mark, the currency used in the German Empire from 1873 to 1914 * German Papiermark, the German currency from 4 August 1914 * German rentenmark, a currency issued on 15 November 1923 to stop the hyperinflation of 1922 and 1923 in Weimar Germany * Lodz Ghetto mark, a special currency for Lodz Ghetto. * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse Transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes. Contrary to a widely held belief, the process does not violate the flows of genetic information as described by the classical central dogma, as transfers of information from RNA to DNA are explicitly held possible. Retroviral RT has three sequential biochemical activities: RNA-dependent DNA polymerase activity, ribonuclease H (RNase H), and DNA-dependent DNA polymerase activity. Collectively, these activities enable the enzyme to convert single-stranded RNA into double-stranded cDNA. In retroviruses and retrotransposons, this cDNA can then integrate into the host ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edmonton
Edmonton ( ) is the capital city of the Canadian province of Alberta. Edmonton is situated on the North Saskatchewan River and is the centre of the Edmonton Metropolitan Region, which is surrounded by Alberta's central region. The city anchors the north end of what Statistics Canada defines as the " Calgary–Edmonton Corridor". As of 2021, Edmonton had a city population of 1,010,899 and a metropolitan population of 1,418,118, making it the fifth-largest city and sixth-largest metropolitan area (CMA) in Canada. Edmonton is North America's northernmost large city and metropolitan area comprising over one million people each. A resident of Edmonton is known as an ''Edmontonian''. Edmonton's historic growth has been facilitated through the absorption of five adjacent urban municipalities ( Strathcona, North Edmonton, West Edmonton, Beverly and Jasper Place) hus Edmonton is said to be a combination of two cities, two towns and two villages./ref> in addition to a ser ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canada
Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by total area. Its southern and western border with the United States, stretching , is the world's longest binational land border. Canada's capital is Ottawa, and its three largest metropolitan areas are Toronto, Montreal, and Vancouver. Indigenous peoples have continuously inhabited what is now Canada for thousands of years. Beginning in the 16th century, British and French expeditions explored and later settled along the Atlantic coast. As a consequence of various armed conflicts, France ceded nearly all of its colonies in North America in 1763. In 1867, with the union of three British North American colonies through Confederation, Canada was formed as a federal dominion of four provinces. This began an accretion of provinces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California
The University of California (UC) is a public land-grant research university system in the U.S. state of California. The system is composed of the campuses at Berkeley, Davis, University of California, Irvine, Irvine, University of California, Los Angeles, Los Angeles, University of California, Merced, Merced, University of California, Riverside, Riverside, University of California, San Diego, San Diego, University of California, San Francisco, San Francisco, University of California, Santa Barbara, Santa Barbara, and University of California, Santa Cruz, Santa Cruz, along with numerous research centers and academic abroad centers. The system is the state's land-grant university. Major publications generally rank most UC campuses as being among the best universities in the world. Six of the campuses, Berkeley, Davis Davis may refer to: Places Antarctica * Mount Davis (Antarctica) * Davis Island (Palmer Archipelago) * Davis Valley, Queen Elizabeth Land Canada * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hong Kong
Hong Kong ( (US) or (UK); , ), officially the Hong Kong Special Administrative Region of the People's Republic of China (abbr. Hong Kong SAR or HKSAR), is a List of cities in China, city and Special administrative regions of China, special administrative region of China on the eastern Pearl River Delta in South China. With 7.5 million residents of various nationalities in a territory, Hong Kong is one of the List of countries and dependencies by population density, most densely populated places in the world. Hong Kong is also a major global financial centre and one of the Global city, most developed cities in the world. Hong Kong was established as a British Hong Kong, colony of the British Empire after the Qing dynasty, Qing Empire ceded Hong Kong Island from Bao'an County, Xin'an County at the end of the First Opium War in 1841 then again in 1842.. The colony expanded to the Kowloon Peninsula in 1860 after the Second Opium War and was further extended when Britain obtaine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all List of life sciences, areas of the life sciences are being uncovered and developed through biochemical methodology and research.#Voet, Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis which allows biomolecule, biological molecules to give rise to the processes that occur within living Cell (biology), cells and between cells,#Karp, Karp (2009), p. 2. in turn relating greatly to the understanding of tissue (biology), tissues and organ (anatomy), organs, as well as organism structure and function.#Miller, Miller (2012). p. 62. Biochemistry is closely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
