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TRANSFAC
TRANSFAC (TRANScription FACtor database) is a manually curated database of eukaryotic transcription factors, their genomic binding sites and DNA binding profiles. The contents of the database can be used to predict potential transcription factor binding sites. Introduction The origin of the database was an early data collection published 1988. The first version that was released under the name TRANSFAC was developed at the former German National Research Centre for Biotechnology and designed for local installation (now: Helmholtz Centre for Infection Research). In one of the first publicly funded bioinformatics projects, launched in 1993, TRANSFAC developed into a resource that became available on the Internet. In 1997, TRANSFAC was transferred to a newly established company, BIOBASE, in order to secure long-term financing of the database. Since then, the most up-to-date version has to be licensed, whereas older versions are free for non-commercial users. Since July 2016, TRA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factors
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization ( body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BIOBASE (company)
BIOBASE is an international bioinformatics company headquartered in Wolfenbüttel, Germany. The company focuses on the generation, maintenance, and licensing of databases in the field of molecular biology, and their related software platforms. History The company was founded in 1997 as a spin-off from the German Research Centre for Biotechnology (GBF), Braunschweig, Germany, known today as the Helmholtz Research Centre for Infection Research. *The founders were scientists of the GBF Research Group Bioinformatics, headed at that time by Edgar Wingender. The company is now managed by Michael Tysiak (CEO/CFO) and Frank Schacherer (COO). The company's original product was the TRANSFAC database, a platform for the description and analysis of gene regulatory events and networks. This was subsequently complemented by a number of smaller databases relevant to aspects of gene regulation, and by an early signaling pathway database (TRANSPATH). TRANSPATH constituted the earliest signal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization ( body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Binding Site
DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.g. a genome) and (2) they are bound by DNA-binding proteins. DNA binding sites are often associated with specialized proteins known as transcription factors, and are thus linked to transcriptional regulation. The sum of DNA binding sites of a specific transcription factor is referred to as its cistrome. DNA binding sites also encompasses the targets of other proteins, like restriction enzymes, site-specific recombinases (see site-specific recombination) and methyltransferases. DNA binding sites can be thus defined as short DNA sequences (typically 4 to 30 base pairs long, but up to 200 bp for recombination sites) that are specifically bound by one or more DNA-binding proteins or protein complexes. It has been reported that some binding sites have potential to undergo fast evolutionary chan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polytechnic University Of Catalonia
The Technical University of Catalonia ( ca, Universitat Politècnica de Catalunya, , es, link=no, Universidad Politécnica de Cataluña; UPC), currently referred to as BarcelonaTech, is the largest engineering university in Catalonia, Spain. It also offers programs in other disciplines such as mathematics and architecture. UPC's objectives are based on internationalization, as it is one of Europe's technical universities with the most international PhD students and the university with the largest share of international master's degree students. UPC is a university aiming at achieving the highest degree of engineering/technical excellence and has bilateral agreements with several top-ranked European universities. UPC is a member of the Top Industrial Managers for Europe network, which allows for student exchanges between leading European engineering schools. It is also a member of several university federations, including the Conference of European Schools for Advanced Eng ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor Binding Site Databases
Transcription factors are proteins that bind genomic regulatory sites. Identification of genomic regulatory elements is essential for understanding the dynamics of developmental, physiological and pathological processes. Recent advances in chromatin immunoprecipitation followed by sequencing (ChIP-seq) have provided powerful ways to identify genome-wide profiling of DNA-binding proteins and histone In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn a ... modifications. The application of ChIP-seq methods has reliably discovered transcription factor binding sites and histone modification sites. Transcription factor binding site databases Comprehensive List of transcription factor binding sites (TFBSs) databases based on ChIP-seq data as follows: References {{Reflist Bioinformatic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Planck Institute For Molecular Genetics
The Max Planck Institute for Molecular Genetics is a research institute for molecular genetics based in Berlin, Germany. It is part of the Max Planck Institute network of the Max Planck Society for the Advancement of Science. Departments and research groups * Department of Developmental Genetics (Bernhard Herrmann) *Department of Genome Regulation (Alexander Meissner) **Genome Regulation Group (Alexander Meissner) **Stem Cell Chromatin Group (Aydan Bulut-Karslioglu) **Lab for Human Brain & Neural Stem Cell Studies (Yechiel Elkabetz) **Precision Gene Control group (Denes Hnisz) **Cellular Phenotyping Group (Franz-Josef Müller) *Department of Computational Molecular Biology (Martin Vingron) **Transcriptional Regulation Group (Martin Vingron) **Mechanisms of Transcriptional Regulation Group (Sebastiaan H. Meijsing) **Chromatin Structure and Function Group (Sarah Kinkley) **Bioinformatics Group (Ralf Herwig) **Research Group Evolutionary Genomics (Peter Arndt) *Otto Warburg Laborato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanjing University
Nanjing University (NJU; ) is a national public research university in Nanjing, Jiangsu. It is a member of C9 League and a Class A Double First Class University designated by the Chinese central government. NJU has two main campuses: the Xianlin campus in the northeast of Nanjing, and the Gulou campus in the city center of Nanjing. Established in 1902 as Sanjiang Normal School, Nanjing University underwent a number of name changes, such as Nanjing Higher Normal School, National Southeastern University and National Central University, until it was renamed Nanjing University in 1950. It merged with the University of Nanking in 1952. NJU is perennially ranked one of the best research universities in China, and one of the most selective universities in the nation. As of 2022, Nanjing University ranked 7th in China and 95th globally by Times Higher Education World University Rankings. Regarding scientific research output, the Nature Index Annual Table 2022 ranked Nanjing Univer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ghent University
Ghent University ( nl, Universiteit Gent, abbreviated as UGent) is a public research university located in Ghent, Belgium. Established before the state of Belgium itself, the university was founded by the Dutch King William I in 1817, when the region was incorporated into the United Kingdom of the Netherlands after the fall of First French Empire. In that same year, he founded two other universities for the southern provinces as well, alongside Ghent University: University of Liège and State University of Leuven. After the Belgian revolution of 1830, the newly formed Belgian state began to administer Ghent University. In 1930, UGent became the first Dutch-speaking university in Belgium. Previously, French (and, even earlier, Latin) had been the standard academic language in what was ''Université de Gand''. In 1991, it was granted major autonomy and changed its name accordingly from ''State University of Ghent'' ( nl, Rijksuniversiteit Gent, abbreviated as ''RUG'') to its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance. A database management system (DBMS) is the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS software additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an app ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Manchester
, mottoeng = Knowledge, Wisdom, Humanity , established = 2004 – University of Manchester Predecessor institutions: 1956 – UMIST (as university college; university 1994) 1904 – Victoria University of Manchester 1880 – Victoria University 1851 – Owens College 1824 – Manchester Mechanics' Institute , endowment = £242.2 million (2021) , budget = £1.10 billion (2020–21) , chancellor = Nazir Afzal (from August 2022) , head_label = President and vice-chancellor , head = Nancy Rothwell , academic_staff = 5,150 (2020) , total_staff = 12,920 (2021) , students = 40,485 (2021) , undergrad = () , postgrad = () , city = Manchester , country = England, United Kingdom , campus = Urban and suburban , colours = Manchester Purple Manchester Yellow , free_label = Scarf , free = , website = , logo = UniOfManchesterLogo.svg , affiliations = Universities Research Association Sutton 30 Russell Group EUA N8 Group NWUA ACUUniversities UK The Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
