|
Timothy A Stewart
Timothy A Stewart (born 30 September 1952) is a molecular biologist. He graduated from the University of Otago (BScHons, PhD.) Stewart was born in Christchurch, New Zealand. He was a pioneer in the technique of transferring recombinant genes to mice (transgenic mice) and in 1988 he and Philip Leder were granted a patent on a genetically engineered mammal. This " oncomouse" patent was the first to be issued covering a higher life form. From 1984 to 2003 Stewart was a scientist at Genentech where he developed the concept that the type I interferons might be a significant component in the initiation or progression of type I diabetes. He has published 61 peer reviewed papers listed in Scopus Scopus is a scientific abstract and citation database, launched by the academic publisher Elsevier as a competitor to older Web of Science in 2004. The ensuing competition between the two databases has been characterized as "intense" and is c ...; the most highly cited has 1013 citation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Otago
The University of Otago () is a public university, public research university, research collegiate university based in Dunedin, Otago, New Zealand. Founded in 1869, Otago is New Zealand's oldest university and one of the oldest universities in Oceania. The university was created by a committee led by Thomas Burns (minister, born 1796), Thomas Burns, and officially established by an ordinance of the Otago Provincial Council in 1869. Between 1874 and 1961 the University of Otago was a part of the federal University of New Zealand, and issued degrees in its name. Otago is known for its vibrant student life, particularly its flatting, which is often in old houses. Otago students have a long-standing tradition of naming their flats. The nickname for Otago students, "Scarfie," comes from the habit of wearing a scarf during the cold southern winters. The nickname "Scarfie" has morphed into the nickname "Breather" in recent years. The university's graduation song, ''Gaudeamus igitur, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christchurch
Christchurch (; ) is the largest city in the South Island and the List of cities in New Zealand, second-largest city by urban area population in New Zealand. Christchurch has an urban population of , and a metropolitan population of over half a million. It is located in the Canterbury Region, near the centre of the east coast of the South Island, east of the Canterbury Plains. It is located near the southern end of Pegasus Bay, and is bounded to the east by the Pacific Ocean and to the south by the ancient volcanic complex of the Banks Peninsula. The Avon River / Ōtākaro, Avon River (Ōtākaro) winds through the centre of the city, with Hagley Park, Christchurch, a large urban park along its banks. With the exception of the Port Hills, it is a relatively flat city, on an average around above sea level. Christchurch has a reputation for being an English New Zealanders, English city, with its architectural identity and nickname the 'Garden City' due to similarities with garde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transgenic Mice
A genetically modified mouse, genetically engineered mouse model (GEMM) or transgenic mouse is a mouse (''Mus musculus'') that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes. Together with patient-derived xenografts (PDXs), GEMMs are the most common ''in vivo'' models in cancer research. The two approaches are considered complementary and may be used to recapitulate different aspects of disease. GEMMs are also of great interest for drug development, as they facilitate target validation and the study of response, resistance, toxicity and pharmacodynamics. History In 1974 Beatrice Mintz and Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. However, the mice did not pass the transgene to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philip Leder
Philip Leder (November 19, 1934 – February 2, 2020) was an American geneticist. Early life and education Leder was born in Washington, D.C., and studied at Harvard University, graduating in 1956. In 1960, he graduated from Harvard Medical School and completed his medical residency at the University of Minnesota. Scientific accomplishments Leder made several contributions in each decade of the modern genetics era from the 1960s through the 1990s. He may be best known for his early work with Marshall Nirenberg in the elucidation of the genetic code and the Nirenberg and Leder experiment. Since then, he has made several contributions in the fields of molecular genetics, immunology and the genetics of cancer. His group defined the base sequence of a complete mammalian gene (the gene for beta globin), which enabled him to determine its organization in detail, including its associated control signals. His research into the structure of genes which carry the code for antibody m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncomouse
The OncoMouse or Harvard mouse is a type of laboratory mouse (''Mus musculus'') that has been genetically modified using modifications designed by Philip Leder and Timothy A Stewart of Harvard University to carry a specific gene called an activated oncogene ( v-Ha-ras under the control of the mouse mammary tumor virus promoter). The activated oncogene significantly increases the mouse's susceptibility to cancer, and thus makes the mouse a suitable model for cancer research. OncoMouse was not the first transgenic mouse to be developed for use in cancer research. Ralph L. Brinster and Richard Palmiter had developed such mice previously. However, OncoMouse was the first mammal to be patented. Because DuPont had funded Philip Leder's research, Harvard University agreed to give DuPont exclusive rights to any inventions commercialized as a result of the funding. Patent applications on the OncoMouse were filed back in the mid-1980s in numerous countries such as in the United States, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genentech
Genentech, Inc. is an American biotechnology corporation headquartered in South San Francisco, California. It operates as an independent subsidiary of holding company Roche. Genentech Research and Early Development operates as an independent center within Roche. Historically, the company is regarded as the world's first biotechnology company. As of July 2021, Genentech employed 13,539 people. History The company was founded in 1976 by venture capitalist Robert A. Swanson and biochemist Herbert Boyer. Boyer is considered to be a pioneer in the field of recombinant DNA technology. In 1973, Boyer and his colleague Stanley Norman Cohen demonstrated that restriction enzymes could be used as "scissors" to cut DNA fragments of interest from one source, to be ligated into a similarly cut plasmid vector. While Cohen returned to the laboratory in academia, Swanson contacted Boyer to found the company. Boyer worked with Arthur Riggs (geneticist), Arthur Riggs and Keiichi Itakura from the Be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Type I Diabetes
Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that occurs when the body's immune system destroys pancreatic cells (beta cells). In healthy persons, beta cells produce insulin. Insulin is a hormone required by the body to store and convert blood sugar into energy. T1D results in high blood sugar levels in the body prior to treatment. Common symptoms include frequent urination, increased thirst, increased hunger, weight loss, and other complications. Additional symptoms may include blurry vision, tiredness, and slow wound healing (owing to impaired blood flow). While some cases take longer, symptoms usually appear within weeks or a few months. The cause of type 1 diabetes is not completely understood, but it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves an autoimmune destruction of the insulin-producing beta cells in the pancreas. Diabetes is diagnosed by testing the level of su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scopus
Scopus is a scientific abstract and citation database, launched by the academic publisher Elsevier as a competitor to older Web of Science in 2004. The ensuing competition between the two databases has been characterized as "intense" and is considered to significantly benefit their users in terms of continuous improvement in coverage, search/analysis capabilities, but not in price. Free database The Lens completes the triad of main universal academic research databases. Journals in Scopus are reviewed for sufficient quality each year according to four numerical measures: ''h''-Index, CiteScore, SJR ( SCImago Journal Rank) and SNIP ( source normalized impact per paper). For this reason, the journals listed in Scopus are considered to meet the requirement for peer review quality established by several research grant agencies for their grant recipients and by degree-accreditation boards in a number of countries. Scopus also allows patent searches from a dedicated patent dat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1952 Births
Events January–February * January 26 – Cairo Fire, Black Saturday in Kingdom of Egypt, Egypt: Rioters burn Cairo's central business district, targeting British and upper-class Egyptian businesses. * February 6 ** Princess Elizabeth, Duchess of Edinburgh, becomes monarch of the United Kingdom of Great Britain and Northern Ireland and the British Dominions: Canada, Australia, New Zealand, Union of South Africa, South Africa, Dominion of Pakistan, Pakistan and Dominion of Ceylon, Ceylon. The princess, who is on a visit to Kenya when she hears of the death of her father, King George VI, aged 56, takes the regnal name Elizabeth II. ** In the United States, a Artificial heart, mechanical heart is used for the first time in a human patient. *February 7 – New York City announces its first crosswalk devices to be installed. * February 14–February 25, 25 – The 1952 Winter Olympics, Winter Olympics are held in Oslo, Norway. * February 15 – The State Funeral of King Ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Zealand Biologists
New or NEW may refer to: Music * New, singer of K-pop group The Boyz * ''New'' (album), by Paul McCartney, 2013 ** "New" (Paul McCartney song), 2013 * ''New'' (EP), by Regurgitator, 1995 * "New" (Daya song), 2017 * "New" (No Doubt song), 1999 * "new", a song by Loona from the 2017 single album '' Yves'' * "The New", a song by Interpol from the 2002 album ''Turn On the Bright Lights'' Transportation * Lakefront Airport, New Orleans, U.S., IATA airport code NEW * Newcraighall railway station, Scotland, station code NEW Other uses * ''New'' (film), a 2004 Tamil movie * New (surname), an English family name * NEW (TV station), in Australia * new and delete (C++), in the computer programming language * Net economic welfare, a proposed macroeconomic indicator * Net explosive weight, also known as net explosive quantity * Network of enlightened Women, an American organization * Newar language, ISO 639-2/3 language code new * Next Entertainment World, a South Korean media company ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
