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TBC1D3
TBC1 domain family member 3E/3F is a protein that in humans is encoded by the ''TBC1D3F'' gene. This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in Rab GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine Chemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addit ... genes on chromosome 17q; this record represents the more centromeric copy. References Further reading * * * * * * * * * * {{gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TBC Domain
The TBC domain is an evolutionarily conserved protein domain found in all eukaryotes. It is approximately 180 to 200 amino acids long. The domain is named for its initial discovery in the proteins USP6, Tre-2, TBC1D1, Bub2, and CDC16, Cdc16. TBC family members act as GTPase-activating proteins (GAPs) for small GTPases in regulating the cell cycle. For example, Rab (G-protein), Rab activity is modulated in part by GAPs, and many RabGAPs share a Tre2/Bub2/Cdc16(TBC)-domain architecture, suggesting that TBC domain-containing proteins may behave similarly. Examples USP6 and CDC16 contain TBC domains. In addition, all proteins in the TBC family contain this domain: Functions TBC mainly functions as a specific Rab GTPases activating proteins, GAP (GTPases activating proteins) by being used as tools to inactivate specific Membrane vesicle trafficking, membrane trafficking events. GTPase-activating protein, GAPs serve to increase GTPase activity by contributing the residues to the ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |