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Stille Reaction
The Stille reaction is a chemical reaction widely used in organic synthesis. The reaction involves the coupling of two organic groups, one of which is carried as an organotin compound (also known as organostannanes). A variety of organic electrophiles provide the other coupling partner. The Stille reaction is one of many palladium-catalyzed coupling reactions.Hartwig, J. F. ''Organotransition Metal Chemistry, from Bonding to Catalysis''; University Science Books: New York, 2010. Stille, J. K. '' Angew. Chem. Int. Ed. Engl.'' 1986, ''25'', 508–524.ReviewFarina, V.; Krishnamurthy, V.; Scott, W. J. ''Org. React.'' 1998, ''50'', 1–652.Review : + \ \ce \ \overbrace^ + \!-\! :*\!,\ : Allyl, alkenyl, aryl, benzyl,acyl :*: halides (Cl, Br, I), pseudohalides (, OPO(OR)2), OAc The R1 group attached to the trialkyltin is normally sp2-hybridized, including vinyl, and aryl groups. These organostannanes are also stable to both air and moisture, and many of these reagents either are c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Kenneth Stille
John Kenneth Stille (May 8, 1930 – July 19, 1989) was an American chemist who discovered the Stille reaction. He received B.A. and M.A. degrees from the University of Arizona before serving in the Navy during the Korean War. He received his Ph.D. from the University of Illinois, where he studied under Carl Shipp Marvel. Stille began his independent career at the University of Iowa in 1957 before moving to Colorado State University in 1977. While at the University of Arizona, Stille met his wife-to-be, Dolores Engelking. He and Dolores were married in 1958 and had two sons, John Robert and James Kenneth. Stille was killed at age 59 in the United Airlines Flight 232 crash at Sioux City, Iowa. In 2010, the Nobel Prize in Chemistry was awarded to Richard F. Heck, Ei-ichi Negishi was a Japanese chemist who was best known for his discovery of the Negishi coupling. He spent most of his career at Purdue University in the United States, where he was the Herbert C. Brown Disti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
