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Stateville Penitentiary Malaria Study
The Stateville Penitentiary malaria study was a controlled but ethically questionable study of the effects of malaria on prisoners of Stateville Penitentiary near Joliet, Illinois, in the 1940s, conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department. The Stateville experiment was viewed as coercive because it offered shortened sentences to participants. The Green report was written in 1945 about it by Andrew Conway Ivy, used in Nuremberg Medical Trial, which affected the Nuremberg Code, and used to discuss how medical experimentation on prisoners should be carried out. Historical context Demand for malaria research The circumstances of World War II resulted in an urgent need for the development of new malaria treatments. First, U.S. soldiers were deployed to areas of the Pacific with extremely high rates of malaria infection. The U.S. Army estimated millions of man-hours lost due to malaria throu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten by an infected mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. Malaria is caused by single-celled microorganisms of the ''Plasmodium'' group. It is spread exclusively through bites of infected ''Anopheles'' mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of ''Plasmodium'' can infect and be spread by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primaquine
Primaquine is a medication used to treat and prevent malaria and to treat ''Pneumocystis'' pneumonia. Specifically it is used for malaria due to ''Plasmodium vivax'' and '' Plasmodium ovale'' along with other medications and for prevention if other options cannot be used. It is an alternative treatment for ''Pneumocystis'' pneumonia together with clindamycin. It is taken by mouth. Common side effects include nausea, vomiting, and stomach cramps. Primaquine should not be given to people with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of red blood cell breakdown. It is often recommended that primaquine not be used during pregnancy. It may be used while breastfeeding if the baby is known not to have G6PD deficiency. The mechanisms of action is not entirely clear but is believed to involve effects on the malaria parasites' DNA. Primaquine was first made in 1946. It is on the World Health Organization's List of Essential Medicines. It is available as a ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Military Tribunal
International is an adjective (also used as a noun) meaning "between nations". International may also refer to: Music Albums * ''International'' (Kevin Michael album), 2011 * ''International'' (New Order album), 2002 * ''International'' (The Three Degrees album), 1975 *''International'', 2018 album by L'Algérino Songs * The Internationale, the left-wing anthem * "International" (Chase & Status song), 2014 * "International", by Adventures in Stereo from ''Monomania'', 2000 * "International", by Brass Construction from ''Renegades'', 1984 * "International", by Thomas Leer from ''The Scale of Ten'', 1985 * "International", by Kevin Michael from ''International'' (Kevin Michael album), 2011 * "International", by McGuinness Flint from ''McGuinness Flint'', 1970 * "International", by Orchestral Manoeuvres in the Dark from '' Dazzle Ships'', 1983 * "International (Serious)", by Estelle from '' All of Me'', 2012 Politics * Political international, any transnational organization ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prisoner Experimentation
Throughout history, prisoners have been frequent participants in scientific, medical and social human subject research. Some of the research involving prisoners has been exploitative and cruel. Many of the modern protections for human subjects evolved in response to the abuses in prisoner research. Research involving prisoners is still conducted today, but prisoners are now one of the most highly protected groups of human subjects Requirements of research involving prisoners According to the Common Rule (45 CFR 46), prisoners may only be included in human subjects research when the research involves no more than a minimal risk of harm. Prisoner consent Prisoners can consent, although their consent cannot be said to be completely voluntary due to their compromised and dependent status. Their status as imprisoned human subjects becomes even more ethically problematic when investigators offer incentives such as parole, phone calls, or objects that are normally unavailable to prisone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life (magazine)
''Life'' was an American magazine published weekly from 1883 to 1972, as an intermittent "special" until 1978, and as a monthly from 1978 until 2000. During its golden age from 1936 to 1972, ''Life'' was a wide-ranging weekly general-interest magazine known for the quality of its photography, and was one of the most popular magazines in the nation, regularly reaching one-quarter of the population. ''Life'' was independently published for its first 53 years until 1936 as a general-interest and light entertainment magazine, heavy on illustrations, jokes, and social commentary. It featured some of the most notable writers, editors, illustrators and cartoonists of its time: Charles Dana Gibson, Norman Rockwell and Jacob Hartman Jr. Gibson became the editor and owner of the magazine after John Ames Mitchell died in 1918. During its later years, the magazine offered brief capsule reviews (similar to those in ''The New Yorker'') of plays and movies currently running in New York City, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Loeb
Nathan Freudenthal Leopold Jr. (November 19, 1904 – August 29, 1971) and Richard Albert Loeb (; June 11, 1905 – January 28, 1936), usually referred to collectively as Leopold and Loeb, were two wealthy students at the University of Chicago who kidnapped and murdered 14-year-old Bobby Franks in Chicago, Illinois, United States, in May 1924. They committed the murder – characterized at the time as "the crime of the century" – hoping to demonstrate superior intellect, which they believed enabled and entitled them to carry out a "perfect crime" without consequences. After the two men were arrested, Loeb's family retained Clarence Darrow as lead counsel for their defense. Darrow's twelve-hour summation at their sentencing hearing is noted for its influential criticism of capital punishment as retributive rather than transformative justice. Both young men were sentenced to life imprisonment plus 99 years. Loeb was murdered by a fellow prisoner in 1936; Leopold was released ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nathan Leopold
Nathan Freudenthal Leopold Jr. (November 19, 1904 – August 29, 1971) and Richard Albert Loeb (; June 11, 1905 – January 28, 1936), usually referred to collectively as Leopold and Loeb, were two wealthy students at the University of Chicago who kidnapped and murdered 14-year-old Bobby Franks in Chicago, Illinois, United States, in May 1924. They committed the murder – characterized at the time as "the crime of the century" – hoping to demonstrate superior intellect, which they believed enabled and entitled them to carry out a "perfect crime" without consequences. After the two men were arrested, Loeb's family retained Clarence Darrow as lead counsel for their defense. Darrow's twelve-hour summation at their sentencing hearing is noted for its influential criticism of capital punishment as retributive rather than transformative justice. Both young men were sentenced to life imprisonment plus 99 years. Loeb was murdered by a fellow prisoner in 1936; Leopold was released o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pamaquine
Pamaquine is an 8-aminoquinoline drug formerly used for the treatment of malaria. It is closely related to primaquine. Synonyms *Plasmochin *Plasmoquine *Plasmaquine Uses Pamaquine is effective against the hypnozoites of the relapsing malarias ('' P. vivax'' and '' P. ovale''); and unlike primaquine, it is also very effective against the erythrocytic stages of all four human malarias. One small clinical trial of pamaquine as a causal prophylactic was disappointing (whereas primaquine is an extremely effective causal prophylactic). Pamaquine is more toxic and less efficacious than primaquine; therefore, pamaquine is no longer routinely used, and of the two, only primaquine is currently recommended by the World Health Organization. Adverse effects Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency. Patients should therefore always be screened for G6PD deficiency prior to being prescribed pamaquine. History Pamaquine was the second synthetic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasmodium Falciparum
''Plasmodium falciparum'' is a unicellular protozoan parasite of humans, and the deadliest species of ''Plasmodium'' that causes malaria in humans. The parasite is transmitted through the bite of a female '' Anopheles'' mosquito and causes the disease's most dangerous form, falciparum malaria. It is responsible for around 50% of all malaria cases. ''P. falciparum'' is therefore regarded as the deadliest parasite in humans. It is also associated with the development of blood cancer (Burkitt's lymphoma) and is classified as a Group 2A (probable) carcinogen. The species originated from the malarial parasite ''Laverania'' found in gorillas, around 10,000 years ago. Alphonse Laveran was the first to identify the parasite in 1880, and named it ''Oscillaria malariae''. Ronald Ross discovered its transmission by mosquito in 1897. Giovanni Battista Grassi elucidated the complete transmission from a female anopheline mosquito to humans in 1898. In 1897, William H. Welch created the na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parasite
Parasitism is a close relationship between species, where one organism, the parasite, lives on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The entomologist E. O. Wilson has characterised parasites as "predators that eat prey in units of less than one". Parasites include single-celled protozoans such as the agents of malaria, sleeping sickness, and amoebic dysentery; animals such as hookworms, lice, mosquitoes, and vampire bats; fungi such as honey fungus and the agents of ringworm; and plants such as mistletoe, dodder, and the broomrapes. There are six major parasitic strategies of exploitation of animal hosts, namely parasitic castration, directly transmitted parasitism (by contact), trophicallytransmitted parasitism (by being eaten), vector-transmitted parasitism, parasitoidism, and micropredation. One major axis of classification concerns invasiveness: an endoparasite lives inside the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protozoa
Protozoa (singular: protozoan or protozoon; alternative plural: protozoans) are a group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic tissues and debris. Historically, protozoans were regarded as "one-celled animals", because they often possess animal-like behaviours, such as motility and predation, and lack a cell wall, as found in plants and many algae. When first introduced by Georg Goldfuss (originally spelled Goldfuß) in 1818, the taxon Protozoa was erected as a class within the Animalia, with the word 'protozoa' meaning "first animals". In later classification schemes it was elevated to a variety of higher ranks, including phylum, subkingdom and kingdom, and sometimes included within Protoctista or Protista. The approach of classifying Protozoa within the context of Animalia was widespread in the 19th and early 20th century, but not universal. By the 1970s, it became usual to require ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasmodium
''Plasmodium'' is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of ''Plasmodium'' species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue (often the liver) before entering the bloodstream to infect red blood cells. The ensuing destruction of host red blood cells can result in malaria. During this infection, some parasites are picked up by a blood-feeding insect ( mosquitoes in majority cases), continuing the life cycle. ''Plasmodium'' is a member of the phylum Apicomplexa, a large group of parasitic eukaryotes. Within Apicomplexa, ''Plasmodium'' is in the order Haemosporida and family Plasmodiidae. Over 200 species of ''Plasmodium'' have been described, many of which have been subdivided into 14 subgenera based on parasite morphology and host range. Evolutionary relationships among different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
