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Robert Weinberg (biologist)
Robert Allan Weinberg (born November 11, 1942) is a biologist, Daniel K. Ludwig Professor for Cancer Research at Massachusetts Institute of Technology (MIT), director of the Ludwig Center of the MIT, and American Cancer Society Research Professor. His research is in the area of oncogenes and the genetic basis of human cancer. Robert Weinberg is also affiliated with the Broad Institute and is a founding member of the Whitehead Institute for Biomedical Research. Weinberg and Eric Lander, a colleague at M.I.T., are co-founders of Verastem, a biopharmaceutical company focused on discovering and developing drugs to treat cancer by targeting cancer stem cells. Career Weinberg earned SB in Biology from Massachusetts Institute of Technology in 1964 and PhD in Biology from the same institute in 1969. He was an instructor in biology at Stillman College in Tuscaloosa, Alabama (1965–1966), and a postdoc in Ernest Winocour's lab at the Weizmann Institute of Science (1969–1970) and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pittsburgh
Pittsburgh ( ) is a city in the Commonwealth of Pennsylvania, United States, and the county seat of Allegheny County. It is the most populous city in both Allegheny County and Western Pennsylvania, the second-most populous city in Pennsylvania behind Philadelphia, and the 68th-largest city in the U.S. with a population of 302,971 as of the 2020 census. The city anchors the Pittsburgh metropolitan area of Western Pennsylvania; its population of 2.37 million is the largest in both the Ohio Valley and Appalachia, the second-largest in Pennsylvania, and the 27th-largest in the U.S. It is the principal city of the greater Pittsburgh–New Castle–Weirton combined statistical area that extends into Ohio and West Virginia. Pittsburgh is located in southwest Pennsylvania at the confluence of the Allegheny River and the Monongahela River, which combine to form the Ohio River. Pittsburgh is known both as "the Steel City" for its more than 300 steel-related businesses and as the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daniel K
Daniel is a masculine given name and a surname of Hebrew origin. It means "God is my judge"Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxford University Press, 2nd edition, , p. 68. (cf. Gabriel—"God is my strength"), and derives from two early biblical figures, primary among them Daniel from the Book of Daniel. It is a common given name for males, and is also used as a surname. It is also the basis for various derived given names and surnames. Background The name evolved into over 100 different spellings in countries around the world. Nicknames (Dan, Danny) are common in both English and Hebrew; "Dan" may also be a complete given name rather than a nickname. The name "Daniil" (Даниил) is common in Russia. Feminine versions ( Danielle, Danièle, Daniela, Daniella, Dani, Danitza) are prevalent as well. It has been particularly well-used in Ireland. The Dutch names "Daan" and "Daniël" are also variations of Daniel. A related surname develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ras (protein)
Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells ( cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in three-dimensional structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation, and survival. Mutations in Ras genes can lead to the production of permanently activated Ras proteins, which can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The three Ras genes in humans (''HRAS'', '' KRAS' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncogene
An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.Kimball's Biology Pages. "Oncogenes" Free full text Most normal cells will undergo a programmed form of rapid cell death () when critical functions are altered and malfunctioning. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes began as proto-oncogenes: normal genes involved in cell growth and proliferation or inhibition of apoptosis. If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they will predis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute For Biological Studies
The Salk Institute for Biological Studies is a scientific research institute located in the La Jolla community of San Diego, California, U.S. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. In 2004, the '' Times Higher Education Supplement'' ranked Salk as the world's top biomedicine research institute, and in 2009 it was ranked number one globally by '' ScienceWatch'' in the neuroscience and behavior areas. The Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renato Dulbecco
Renato Dulbecco ( , ; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells. He studied at the University of Turin under Giuseppe Levi, along with fellow students Salvador Luria and Rita Levi-Montalcini, who also moved to the U.S. with him and won Nobel prizes. He was drafted into the Italian army in World War II, but later joined the resistance. Early life Dulbecco was born in Catanzaro (Southern Italy), but spent his childhood and grew up in Liguria, in the coastal city Imperia. He graduated from high school at 16, then moved to the University of Turin. Despite a strong interest in mathematics and physics, he decided to study medicine. At only 22, he graduated in morbid anatomy and pathology under the supervision of professor Giuseppe Levi. During these years he met Salvador Luria and Rita Levi-M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weizmann Institute Of Science
The Weizmann Institute of Science ( he, מכון ויצמן למדע ''Machon Vaitzman LeMada'') is a public research university in Rehovot, Israel, established in 1934, 14 years before the State of Israel. It differs from other Israeli universities in that it offers only postgraduate degrees in the natural and exact sciences. It is a multidisciplinary research center, with around 3,800 scientists, postdoctoral fellows, Ph.D. and M.Sc. students, and scientific, technical, and administrative staff working at the institute. As of 2019, six Nobel laureates and three Turing Award winners have been associated with the Weizmann Institute of Science. History Founded in 1934 by Chaim Weizmann and his first team, among them Benjamin M. Bloch, as the Daniel Sieff Research Institute. Weizmann had offered the post of director to Nobel Prize laureate Fritz Haber, but took over the directorship himself after Haber's death en route to Palestine. Before he became President of the St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuscaloosa, Alabama
Tuscaloosa ( ) is a city in and the seat of Tuscaloosa County in west-central Alabama, United States, on the Black Warrior River where the Gulf Coastal and Piedmont plains meet. Alabama's fifth-largest city, it had an estimated population of 101,129 in 2019. It was known as Tuskaloosa until the early 20th century. It is also known as ''"the Druid City"'' because of the numerous water oaks planted in its downtown streets since the 1840s. Incorporated on December 13, 1819, it was named after Tuskaloosa, the chief of a band of Muskogean-speaking people defeated by the forces of Spanish explorer Hernando de Soto in 1540 in the Battle of Mabila, in what is now central Alabama. It served as Alabama's capital city from 1826 to 1846. Tuscaloosa is the regional center of industry, commerce, healthcare and education for the area of west-central Alabama known as ''West Alabama;'' and the principal city of the Tuscaloosa Metropolitan Statistical Area, which includes Tuscaloosa, H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stillman College
Stillman College is a private historically black Presbyterian college in Tuscaloosa, Alabama. It awards the Bachelor of Arts and Bachelor of Science degrees in 17 disciplines/majors housed within three academic schools (Arts and Sciences, Business Administration, and Education). The college has an average enrollment of 650 students and is accredited by the Southern Association of Colleges and Schools. History Stillman College was founded as Tuscaloosa Institute, when it was authorized by the General Assembly of the Presbyterian Church in the United States in 1875, and held its first classes in 1876. It was chartered as a legal corporation by the State of Alabama in 1895. At that time, the name was changed from Tuscaloosa Institute to Stillman Institute. The institute was a concept initiated by the Reverend Dr. Charles Allen Stillman, pastor of First Presbyterian Church of Tuscaloosa, "for the training of colored men for the ministry". The mandate for the Institution expande ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Stem Cells
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. Existing cancer treatments have mostly been developed based on animal models, where therapies able to promote tumor shrinkage were deemed effective. However, animals do not provide a complete ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric Lander
Eric Steven Lander (born February 3, 1957) is an American mathematician and geneticist who served as the 11th director of the Office of Science and Technology Policy and Science Advisor to the President, serving on the presidential Cabinet. Lander is a professor of biology at the Massachusetts Institute of Technology (MIT), a professor of systems biology at Harvard Medical School, a former member of the Whitehead Institute, and the founding director of the Broad Institute. He is a 1987 MacArthur Fellow and Rhodes Scholar. Lander co-chaired President Barack Obama's Council of Advisors on Science and Technology. Lander announced he would resign from the Biden Administration effective February 18, 2022 after allegations surfaced he had engaged in bullying and abusive conduct directed against his subordinates and other White House staff. Early life and education Lander was born in Brooklyn, New York City, to Jewish parents, the son of Rhoda G. Lander, a social studies teacher, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
