Ramoplanin
Ramoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of ''Actinoplanes''. It is effective against Gram-positive bacteria. Mechanism It exerts its bacteriocidal effect by inhibiting cell wall biosynthesis, acting by inhibiting the transglycosylation step of peptidoglycan synthesis. Ramoplanin specifically binds to and sequesters lipid intermediates I and II, preventing intracellular glycosyltransferase (MurG) and other steps of the peptidoglycan assembly system. Uses Its development has been fast-tracked by the U.S. Food and Drug Administration as a treatment for multiple antibiotic-resistant '' Clostridium difficile'' infection of the gastrointestinal tract, Unlike vancomycin, it is absorbed in the gastrointestinal tract, although it is unstable in the bloodstream, so can be taken only orally against ''Clostridium difficile'' infections of the gastrointestinal tract. Ramoplanin is "particularly useful" in cases ''E. faecalis'' no ma ...
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