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RHOT1
Mitochondrial Rho GTPase 1 (MIRO1) is an enzyme that in humans is encoded by the ''RHOT1'' gene on chromosome 17. As a Miro (protein), Miro protein isoform, the protein facilitates mitochondrial transport by attaching the mitochondria to the motor/adaptor complex. Through its key role in mitochondrial transport, RHOT1 is involved in mitochondrial homeostasis and apoptosis, as well as Parkinson's disease (PD) and cancer. Structure In mammals, RHOT1 is one of two Miro isoforms. Both isoforms share a structure consisting of two EF-hand motifs linking two GTP-binding domains and a C-terminal transmembrane domain that attaches the protein to the outer mitochondrial membrane (OMM). The EF-hand motifs serve as binding sites for the adaptor protein Milton and the KIF5B, kinesin heavy chain. These domains can also bind calcium ions, and the binding results in a conformational change that dissociates the mitochondrial surface from kinesin. Function RHOT1 is a member of the Rho family of G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RHOT2
Mitochondrial Rho GTPase 2 is an enzyme that in humans is encoded by the ''RHOT2'' gene. As a Miro (protein), Miro protein isoform, the protein facilitates mitochondrial transport by attaching the mitochondria to the motor/adaptor complex. Through its key role in mitochondrial transport, RHOT2 is involved in mitochondrial homeostasis and apoptosis, as well as Parkinson’s disease (PD). Structure In mammals, RHOT2 is one of two Miro isoforms. Both isoforms share a structure consisting of two EF-hand motifs linking two GTP-binding domains and a C-terminal transmembrane domain that attaches the protein to the outer mitochondrial membrane (OMM). The EF-hand motifs serve as binding sites for the adaptor protein Milton and the KIF5B, kinesin heavy chain. These domains can also bind calcium ions, and the binding results in a conformational change that dissociates the mitochondrial surface from kinesin. Function RHOT2 is a member of the Rho family of GTPases, Rho GTPase family and one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |