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Robert Weinberg (biologist)
Robert Allan Weinberg (born November 11, 1942) is an American biologist, Daniel K. Ludwig Professor for Cancer Research at Massachusetts Institute of Technology (MIT), director of the Ludwig Center of the MIT, and American Cancer Society Research Professor. His research is in the area of oncogenes and the genetic basis of human cancer. Robert Weinberg is also affiliated with the Broad Institute and is a founding member of the Whitehead Institute for Biomedical Research. Weinberg and Eric Lander, a colleague at M.I.T., are co-founders of Verastem, a biopharmaceutical company focused on discovering and developing drugs to treat cancer by targeting cancer stem cells. Career Weinberg earned SB in Biology from Massachusetts Institute of Technology in 1964 and PhD in biology from the same institute in 1969. He was an instructor in biology at Stillman College in Tuscaloosa, Alabama (1965–1966), and a postdoc in Ernest Winocour's lab at the Weizmann Institute of Science (1969� ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pittsburgh
Pittsburgh ( ) is a city in Allegheny County, Pennsylvania, United States, and its county seat. It is the List of municipalities in Pennsylvania#Municipalities, second-most populous city in Pennsylvania (after Philadelphia) and the List of United States cities by population, 67th-most populous city in the U.S., with a population of 302,971 as of the 2020 United States census, 2020 census. The city is located in Western Pennsylvania, southwestern Pennsylvania at the confluence of the Allegheny River and Monongahela River, which combine to form the Ohio River. It anchors the Greater Pittsburgh, Pittsburgh metropolitan area, which had a population of 2.457 million residents and is the largest metro area in both the Ohio Valley and Appalachia, the Pennsylvania metropolitan areas, second-largest in Pennsylvania, and the List of metropolitan statistical areas, 26th-largest in the U.S. Pittsburgh is the principal city of the greater Pittsburgh–New Castle–Weirton combined statistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daniel K
Daniel commonly refers to: * Daniel (given name), a masculine given name and a surname * List of people named Daniel * List of people with surname Daniel * Daniel (biblical figure) * Book of Daniel, a biblical apocalypse, "an account of the activities and visions of Daniel" Daniel may also refer to: Arts and entertainment Literature * ''Daniel'' (Old English poem), an adaptation of the Book of Daniel * ''Daniel'', a 2006 novel by Richard Adams * ''Daniel'' (Mankell novel), 2007 Music * "Daniel" (Bat for Lashes song) (2009) * "Daniel" (Elton John song) (1973) * "Daniel", a song from '' Beautiful Creature'' by Juliana Hatfield * ''Daniel'' (album), a 2024 album by Real Estate Other arts and entertainment * ''Daniel'' (1983 film), by Sidney Lumet * ''Daniel'' (2019 film), a Danish film * Daniel (comics), a character in the ''Endless'' series Businesses * Daniel (department store), in the United Kingdom * H & R Daniel, a producer of English porcelain between 1827 and 184 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ras (protein)
Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells ( cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in three-dimensional structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation, and survival. Mutations in Ras genes can lead to the production of permanently activated Ras proteins, which can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The three Ras genes in humans (''HRAS'', ''KRAS'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncogene
An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.Kimball's Biology Pages. "Oncogenes" Free full text Most normal cells undergo a preprogrammed rapid cell death () if critical functions are altered and then malfunction. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes began as proto-oncogenes: normal genes involved in cell growth and proliferation or inhibition of apoptosis. If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they predispose the cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute For Biological Studies
The Salk Institute for Biological Studies is a scientific research institute in the La Jolla community of San Diego, California. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. As of October 2020, the Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer's disease, Parkinson's disease, AIDS, and the neurobiology of American Sign Language. March of Dimes provided the initial funding and continues to support the institute. Research is funded by a variety of public sour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renato Dulbecco
Renato Dulbecco ( , ; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells. He studied at the University of Turin under Giuseppe Levi, along with fellow students Salvador Luria and Rita Levi-Montalcini, who also moved to the U.S. with him and won Nobel prizes. He was drafted into the Italian army in World War II, but later joined the resistance. Early life Dulbecco was born in Catanzaro (Calabria, Southern Italy), but spent his childhood and grew up in Liguria, in the coastal city Imperia. He graduated from high school at 16, then moved to the University of Turin. Despite a strong interest in mathematics and physics, he decided to study medicine. At only 22, he graduated in morbid anatomy and pathology under the supervision of professor Giuseppe Levi. During these years he met Salvador Luria and Rit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weizmann Institute Of Science
The Weizmann Institute of Science ( ''Machon Weizmann LeMada'') is a Public university, public research university in Rehovot, Israel, established in 1934, fourteen years before the State of Israel was founded. Unlike other List of Israeli universities and colleges, Israeli universities it exclusively offers postgraduate-only degrees in the natural science, natural and exact sciences. The institute is a multidisciplinary research center, employing around 3,800 scientists, Postdoctoral researcher, postdoctoral fellows, Ph.D. and M.Sc. students, and scientific, technical, and administrative staff working at the institute. As of 2019, the Weizmann Institute of Science has been associated with six Nobel laureates and three Turing Award winners. The Weizmann Institute of Science and Elbit Systems have collaborated on various projects, notably including the development and supply of the space telescope for Israel's Ultraviolet Transient Astronomy Satellite (ULTRASAT) program and re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuscaloosa, Alabama
Tuscaloosa ( ) is a city in and the county seat of Tuscaloosa County, Alabama, Tuscaloosa County in west-central Alabama, United States, on the Black Warrior River where the Gulf Coastal Plain, Gulf Coastal and Piedmont (United States), Piedmont plains meet. List of municipalities in Alabama, Alabama's fifth-most populous city, the population was 99,600 at the 2020 United States census, 2020 census, and was estimated to be 111,338 in 2023. It was known as Tuskaloosa until the early 20th century. It is also known as "the Druid City" because of the numerous Quercus nigra, water oaks planted in its downtown streets since the 1840s. Incorporated on December 13, 1819, it was named after Tuskaloosa, the chief of a band of Muskogean languages, Muskogean-speaking people defeated by the forces of Spanish explorer Hernando de Soto (explorer), Hernando de Soto in 1540 in the Mabila, Battle of Mabila, in what is now central Alabama. It served as Alabama's capital city from 1826 to 1846, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stillman College
Stillman College is a Private college, private historically black colleges and universities, historically black Presbyterian Church (USA), Presbyterian college in Tuscaloosa, Alabama. It awards Bachelor of Arts and Bachelor of Science degrees in 22 programs housed within three academic schools (School of Arts and Sciences, School of Business Entrepreneurship and CIS, amend School of Education). The college has an average enrollment of 728 students and is Higher education accreditation in the United States, accredited by the Southern Association of Colleges and Schools. History Stillman College was founded as Tuscaloosa Institute, when it was authorized by the General Assembly of the Presbyterian Church in the United States in 1875, and held its first classes in 1876. It was chartered as a legal corporation by the State of Alabama in 1895. At that time, the name was changed from Tuscaloosa Institute to Stillman Institute. The institute was a concept initiated by Charles Alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Stem Cells
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. Existing cancer treatments have mostly been developed based on animal models, where therapies able to promote tumor shrinkage were deemed effective. However, animals do not provide a complete ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric Lander
Eric Steven Lander (born February 3, 1957) is an American mathematician and geneticist who is a professor of biology at the Massachusetts Institute of Technology (MIT), and a professor of systems biology at Harvard Medical School. Eric Lander is founding director emeritus of the Broad Institute of MIT and Harvard. Lander served as the 11th director of the Office of Science and Technology Policy and Science Advisor to the President in Joe Biden's Cabinet of the United States, presidential Cabinet. In response to allegations that he had engaged in bullying and abusive conduct, Lander apologized and resigned from the Biden Administration effective February 18, 2022. Early life and education Lander was born in Brooklyn, New York City, to American Jews, Jewish parents, the son of Rhoda G. Lander, a social studies teacher, and Harold Lander, an attorney. He was captain of the math team at Stuyvesant High School, graduating in 1974 as valedictorian and an International Mathematical Oly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
