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RAB11A
Ras-related protein Rab-11A is a protein that in humans is encoded by the ''RAB11A'' gene. Function The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Rab-11a controls intracellular trafficking of the innate immune receptor TLR4, and thereby also receptor signaling Interactions RAB11A has been shown to interact with: * RAB11FIP1, * RAB11FIP2, * RAB11FIP3, * RAB11FIP4, and * RAB11FIP5 *Moesin Moesin is a protein that in humans is encoded by the ''MSN'' gene. Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers ... References Further reading * * * * * * * * * * * * * * * * * {{PDB Gallery, geneid=8766 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB11FIP1
Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the ''RAB11FIP1'' gene. Function Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases. RAB11FIP1 has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the adipocyte. RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations. Interactions RAB11FIP1 has been shown to interact with RAB11A and RAB4A Ras-related protein Rab-4A is a protein that in humans is encoded by the ''RAB4A'' gene. Interactions RAB4A has been shown to interact with: * CD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB11FIP2
Rab11 family-interacting protein 2 is a protein that in humans is encoded by the ''RAB11FIP2'' gene. Interactions RAB11FIP2 has been shown to interact with MYO5B, RAB11A Ras-related protein Rab-11A is a protein that in humans is encoded by the ''RAB11A'' gene. Function The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated se ... and RAB25. References Further reading * * * * * * * * * * * * * * * External links * {{Gene-10-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB11FIP3
Rab11 family-interacting protein 3 is a protein that in humans is encoded by the ''RAB11FIP3'' gene. Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001). upplied by OMIMref name="entrez" /> Interactions RAB11FIP3 has been shown to interact with RAB11A Ras-related protein Rab-11A is a protein that in humans is encoded by the ''RAB11A'' gene. Function The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated se .... References Further reading * * * * * * * * * * * * * * * EF-hand-containing proteins {{Gene-16-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB11FIP4
Rab11 family-interacting protein 4 is a protein that in humans is encoded by the ''RAB11FIP4'' gene. Interactions RAB11FIP4 has been shown to interact with RAB11A Ras-related protein Rab-11A is a protein that in humans is encoded by the ''RAB11A'' gene. Function The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated se .... References Further reading * * * * * * * * * {{gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB11FIP5
Rab11 family-interacting protein 5 is a protein that in humans is encoded by the ''RAB11FIP5'' gene. Interactions RAB11FIP5 has been shown to interact with RAB11A and RAB25. Vesicle trafficking Rab11FIP5 is one of the many proteins that have been shown to interact with the Rab11 protein. Rab GTPases, such as Rab11, are enzymes that are involved in vesicular trafficking. Rab11 specifically plays a key role in endocytic trafficking and recycling through guiding early endosomes to endosome recycling complexes. Rab11FIP5, like most other Rab11FIP proteins, interacts with Rab11 by serving as an adaptor protein. This leads to downstream changes with regards to which proteins can interact. This is a result of the various Rab11FIP proteins that each have different binding partners. This process allows for the coordination and organization of endosomal transport and ultimately gives Rab11 its versatile function in the cell. It is believed that Rab11 recruits specific Rab11FIP prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Innate Immunity
The innate immune system or nonspecific immune system is one of the two main immunity strategies in vertebrates (the other being the adaptive immune system). The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, prokaryotes, and invertebrates (see Beyond vertebrates).. The major functions of the innate immune system are to: * recruit immune cells to infection sites by producing chemical factors, including chemical mediators called cytokines * activate the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells * identify and remove foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells * activate the adaptive immune system through antigen presentation * act as a physical and chemical barrier to infectious agents; via physical measures such as skin and mucus, and chemical measures such as clotting factors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Receptor
An immune receptor (or immunologic receptor) is a Receptor (biochemistry), receptor, usually on a cell membrane, which binds to a Ligand (biochemistry), ligand (usually another protein, such as cytokine) and causes a response in the immune system. Types The main receptors in the immune system are pattern recognition receptors (PRRs), Toll-like receptors (TLRs), killer activated receptor, killer activated and killer inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell receptors.Lippincott's Illustrated Reviews: Immunology. Paperback: 384 pages. Publisher: Lippincott Williams & Wilkins; (July 1, 2007). Language: English. . . Page 20 See also * Antigen References External links * {{Immune receptors Immune system Single-pass transmembrane proteins Transmembrane receptors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TLR4
Toll-like receptor 4 (TLR4), also designated as CD284 (cluster of differentiation 284), is a key activator of the innate immune response and plays a central role in the fight against bacterial infections. TLR4 is a transmembrane protein of approximately 95 kDa that is encoded by the ''TLR4'' gene. TLR4 belongs to the toll-like receptor family which is representative of the pattern recognition receptors (PRR), so named for their ability to recognize evolutionarily conserved components of microorganisms (bacteria, viruses, fungi and parasites) called pathogen-associated molecular patterns (PAMPs). The recognition of a PAMP by a PRR triggers rapid activation of the innate immunity essential to fight infectious diseases. TLR4 is expressed in immune cells mainly of myeloid origin, including monocytes, macrophages and dendritic cells (DC). It is also expressed at a lower level on some non-immune cells, including epithelium, endothelium, placental cells and beta cells in Langerhans i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
