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Proxicromil
Proxicromil is a detergent-like, lipophilic oral medication developed in the late 1970s that was not admitted on the market because of its possible carcinogenic effects. It suppresses allergic reactions by binding to FcεRI receptor in mast cells, thereby inhibiting production of histamines. It is absorbed through the gastrointestinal tract, and has been proven hepatotoxic for dogs as a result of its accumulation in biliary canaliculus, biliary canaliculi. History Proxicromil was developed in the late 1970s as an oral analogue and a successor of anti-allergy drug Cromoglicic acid, Intal, whose patent protection period was to expire in 1982. Disodium cromoglycate in the form of an inhaler licensed as Intal (derived from ‘interfere with allergy’) had become the Fisons company's leading product, generating immense income and stimulating further research; thus several attempts at developing a Congener (chemistry), congener were undertaken. Nevertheless, because of its possible ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Detergent
A detergent is a surfactant or a mixture of surfactants with Cleanliness, cleansing properties when in Concentration, dilute Solution (chemistry), solutions. There are a large variety of detergents. A common family is the alkylbenzene sulfonates, which are soap-like compounds that are more soluble than soap in hard water, because the polar sulfonate is less likely than the polar carboxylate of soap to bind to calcium and other ions found in hard water. Definitions The word ''detergent'' is derived from the Latin adjective , from the verb , meaning to wipe or polish off. Detergent can be defined as a surfactant or a mixture of surfactants with cleansing properties when in Concentration, dilute Solution (chemistry), solutions. However, conventionally, detergent is used to mean synthetic cleaning compounds as opposed to ''soap'' (a salt of the natural fatty acid), even though soap is also a detergent in the true sense. In domestic contexts, the term ''detergent'' refers to househ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
