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Pressure–volume Loop Experiments
Pressure–volume loops are widely used in Biomedical research, basic and preclinical research. Left ventricular PV loops are considered to be the gold standard for hemodynamics, hemodynamic assessment and are widely used in research to evaluate cardiac performance. While it has long been possible to measure pressure in real time from the left Ventricle (heart), ventricle, measuring the volume was technically more difficult. The use of ultrasonic sonomicrometry and the development of the conductance catheter triggered renewed interest in PV loops studies. In sonomicrometry, small ultrasonic transducers (usually referred to as "crystals") transmit signals to each other, and the distance between them is accurately determined based on the transit-time of the signals. By knowing the long and short axis lengths of the ventricle, ventricular volume is easily and accurately determined. Conductance catheters measure instantaneous conductance in the left ventricle, which is then converte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedical Research
Medical research (or biomedical research), also known as health research, refers to the process of using scientific methods with the aim to produce knowledge about human diseases, the prevention and treatment of illness, and the promotion of health. Medical research encompasses a wide array of research, extending from " basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pressure–volume Loop Analysis In Cardiology
A plot of a system's Pressure-volume curves, pressure versus volume has long been used to measure the work done by the system and its efficiency. This analysis can be applied to heat engines and pumps, including the heart. A considerable amount of information on cardiac performance can be determined from the ''pressure vs. volume'' plot (pressure–volume diagram). A number of pressure–volume loop experiments, methods have been determined for measuring PV-loop values experimentally. Cardiac pressure–volume loops Real-time Ventricle (heart), left ventricular (LV) pressure–volume loops provide a framework for understanding cardiac mechanics in experimental animals and humans. Such loops can be generated by real-time measurement of pressure and volume within the left ventricle. Several physiologically relevant Hemodynamics, hemodynamic parameters such as stroke volume, cardiac output, ejection fraction, myocardial contractility, etc. can be determined from these loops. To ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pressure–volume Diagram
A pressure–volume diagram (or PV diagram, or volume–pressure loop) is used to describe corresponding changes in volume and pressure in a system. It is commonly used in thermodynamics, cardiovascular physiology, and respiratory physiology. PV diagrams, originally called indicator diagrams, were developed in the 18th century as tools for understanding the efficiency of steam engines. Description A PV diagram plots the change in pressure ''P'' with respect to volume ''V'' for some process or processes. Typically in thermodynamics, the set of processes forms a cycle, so that upon completion of the cycle there has been no net change in state of the system; i.e. the device returns to the starting pressure and volume. The figure shows the features of an idealized PV diagram. It shows a series of numbered states (1 through 4). The path between each state consists of some process (A through D) which alters the pressure or volume of the system (or both). A key feature of the diagr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Processing
Signal processing is an electrical engineering subfield that focuses on analyzing, modifying and synthesizing ''signals'', such as audio signal processing, sound, image processing, images, Scalar potential, potential fields, Seismic tomography, seismic signals, Altimeter, altimetry processing, and scientific measurements. Signal processing techniques are used to optimize transmissions, Data storage, digital storage efficiency, correcting distorted signals, improve subjective video quality, and to detect or pinpoint components of interest in a measured signal. History According to Alan V. Oppenheim and Ronald W. Schafer, the principles of signal processing can be found in the classical numerical analysis techniques of the 17th century. They further state that the digital refinement of these techniques can be found in the digital control systems of the 1940s and 1950s. In 1948, Claude Shannon wrote the influential paper "A Mathematical Theory of Communication" which was publis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wiki Pv Edpvr+edspvr
A wiki ( ) is a form of hypertext publication on the internet which is collaboratively edited and managed by its audience directly through a web browser. A typical wiki contains multiple pages that can either be edited by the public or limited to use within an organization for maintaining its internal knowledge base. Its name derives from the first user-editable website called "WikiWikiWeb," with "wiki" being a Hawaiian word meaning "quick." Wikis are powered by wiki software, also known as wiki engines. Being a form of content management system, these differ from other web-based systems such as blog software or static site generators in that the content is created without any defined owner or leader. Wikis have little inherent structure, allowing one to emerge according to the needs of the users. Wiki engines usually allow content to be written using a lightweight markup language and sometimes edited with the help of a rich-text editor. There are dozens of different wik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preload (cardiology)
In cardiac physiology, preload is the amount of sarcomere stretch experienced by cardiac muscle cells, called cardiomyocytes, at the end of ventricular filling during diastole. Preload is directly related to ventricular filling. As the relaxed ventricle fills during diastole, the walls are stretched and the length of sarcomeres increases. Sarcomere length can be approximated by the volume of the ventricle because each shape has a conserved surface-area-to-volume ratio. This is useful clinically because measuring the sarcomere length is destructive to heart tissue. It requires cutting out a piece of cardiac muscle to look at the sarcomeres under a microscope. It is currently not possible to directly measure preload in the beating heart of a living animal. Preload is estimated from end-diastolic ventricular pressure and is measured in millimeters of mercury (mmHg). Estimating preload Though not exactly equivalent to the strict definition of ''preload,'' end-diastolic volume ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wiki Pv Par Conductance
A wiki ( ) is a form of hypertext publication on the internet which is Collaborative editing, collaboratively edited and managed by its audience directly through a web browser. A typical wiki contains multiple pages that can either be edited by the public or limited to use within an organization for maintaining its internal knowledge base. Its name derives from the first user-editable website called "WikiWikiWeb," with "wiki" being a Hawaiian language, Hawaiian word meaning "quick." Wikis are powered by wiki software, also known as wiki engines. Being a form of content management system, these differ from other web application, web-based systems such as blog software or static site generators in that the content is created without any defined owner or leader. Wikis have little inherent structure, allowing one to emerge according to the needs of the users. Wiki engines usually allow content to be written using a lightweight markup language and sometimes edited with the help ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemodynamics
Hemodynamics or haemodynamics are the dynamics of blood flow. The circulatory system is controlled by homeostatic mechanisms of autoregulation, just as hydraulic circuits are controlled by control systems. The hemodynamic response continuously monitors and adjusts to conditions in the body and its environment. Hemodynamics explains the physical laws that govern the flow of blood in the blood vessels. Blood flow ensures the transportation of nutrients, hormones, metabolic waste products, oxygen, and carbon dioxide throughout the body to maintain cell-level metabolism, the regulation of the pH, osmotic pressure and temperature of the whole body, and the protection from microbial and mechanical harm. Blood is a non-Newtonian fluid, and is most efficiently studied using rheology rather than hydrodynamics. Because blood vessels are not rigid tubes, classic hydrodynamics and fluids mechanics based on the use of classical viscometers are not capable of explaining haemodynamics. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calibration
In measurement technology and metrology, calibration is the comparison of measurement values delivered by a device under test with those of a calibration standard of known accuracy. Such a standard could be another measurement device of known accuracy, a device generating the quantity to be measured such as a voltage, a sound tone, or a physical artifact, such as a meter ruler. The outcome of the comparison can result in one of the following: * no significant error being noted on the device under test * a significant error being noted but no adjustment made * an adjustment made to correct the error to an acceptable level Strictly speaking, the term "calibration" means just the act of comparison and does not include any subsequent adjustment. The calibration standard is normally traceable to a national or international standard held by a metrology body. BIPM Definition The formal definition of calibration by the International Bureau of Weights and Measures (BIPM) is the foll ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrical Conductance
The electrical resistance of an object is a measure of its opposition to the flow of electric current. Its reciprocal quantity is , measuring the ease with which an electric current passes. Electrical resistance shares some conceptual parallels with mechanical friction. The SI unit of electrical resistance is the ohm (), while electrical conductance is measured in siemens (S) (formerly called the 'mho' and then represented by ). The resistance of an object depends in large part on the material it is made of. Objects made of electrical insulators like rubber tend to have very high resistance and low conductance, while objects made of electrical conductors like metals tend to have very low resistance and high conductance. This relationship is quantified by resistivity or conductivity. The nature of a material is not the only factor in resistance and conductance, however; it also depends on the size and shape of an object because these properties are extensive rather tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
