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Pioneer Factor
Pioneer factors are transcription factors that can directly bind condensed chromatin. They can have positive and negative effects on transcription and are important in recruiting other transcription factors and histone modification enzymes as well as controlling DNA methylation. They were first discovered in 2002 as factors capable of binding to target sites on nucleosomal DNA in compacted chromatin and endowing competency for gene activity during hepatogenesis. Pioneer factors are involved in initiating cell differentiation and activation of cell-specific genes. This property is observed in histone fold-domain containing transcription factors (fork head box (FOX) and NF-Y) and other transcription factors that use zinc finger(s) for DNA binding (Groucho TLE, Gal4, and GATA). The eukaryotic cell condenses its genome into tightly packed chromatin and nucleosomes. This ability saves space in the nucleus for only actively transcribed genes and hides unnecessary or detrimental g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are Gene expression, expressed in the desired Cell (biology), cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are approximately 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histone H1
Histone H1 is one of the five main histone protein families which are components of chromatin in eukaryotic cells. Though highly conserved, it is nevertheless the most variable histone in sequence across species. Structure Metazoan H1 proteins feature a central globular "winged helix" domain and long C- and short N-terminal tails. H1 is involved with the packing of the "beads on a string" sub-structures into a high order structure, whose details have not yet been solved. H1 found in protists and bacteria, otherwise known as nucleoproteins HC1 and HC2 (, ), lack the central domain and the N-terminal tail. H1 is less conserved than core histones. The globular domain is the most conserved part of H1. Function Unlike the other histones, H1 does not make up the nucleosome "bead". Instead, it sits on top of the structure, keeping in place the DNA that has wrapped around the nucleosome. H1 is present in half the amount of the other four histones, which contribute two molecule ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cysteine
Cysteine (; symbol Cys or C) is a semiessential proteinogenic amino acid with the chemical formula, formula . The thiol side chain in cysteine enables the formation of Disulfide, disulfide bonds, and often participates in enzymatic reactions as a nucleophile. Cysteine is chiral, but both D and L-cysteine are found in nature. LCysteine is a protein monomer in all biota, and D-cysteine acts as a signaling molecule in mammalian nervous systems. Cysteine is named after its discovery in urine, which comes from the urinary bladder or cyst, from Ancient Greek, Greek κύστις ''kýstis'', "bladder". The thiol is susceptible to oxidation to give the disulfide bond, disulfide derivative cystine, which serves an important structural role in many proteins. In this case, the symbol Cyx is sometimes used. The deprotonated form can generally be described by the symbol Cym as well. When used as a food additive, cysteine has the E number E920. Cysteine is Genetic code, encoded by the codo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pioneer Factor In The Cell Differentiation
Pioneer commonly refers to a person who is among the first at something that is new to a community. A pioneer as a settler is among the first settling at a place that is new to the settler community. A historic example are American pioneers, persons in American history who migrated westward to settle in what is now the Western and Midwestern United States. Pioneer, The Pioneer, or pioneering may also refer to: Companies and organizations *Pioneer Aerospace Corporation *Pioneer Chicken, an American fast-food restaurant chain *Pioneer Club Las Vegas, a casino in Las Vegas, Nevada, U.S. *Pioneer Corporation, a Japanese electronics manufacturer *Pioneer Energy, a Canadian gas station chain *Pioneer Entertainment, a Japanese anime company *Pioneer Fund, racist foundation, 1937 *Pioneer Hi-Bred, a U.S.-based agriculture company *Pioneer Hotel & Gambling Hall, Laughlin, Nevada, U.S. *Pioneer Instrument Company, an American aeronautical instrument manufacturer *Pioneer movement, a commu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucocorticoid Receptor
The glucocorticoid receptor (GR or GCR) also known by its gene name ''NR3C1'' ( nuclear receptor subfamily 3, group C, member 1) is the steroid receptor for glucocorticoids such as cortisol. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, inflammation, and immune response. Because the receptor gene is expressed in several forms, it has many different ( pleiotropic) effects in different parts of the body and in the context of different diseases. GR is a steroid receptor and thus its canonical action is similar to other steroid receptors. ree full text/ref> The unbound receptor resides in the cytosol of the cell. When glucocorticoids bind to the receptor, GR translocates to the nucleus of the cell where it acts as a transcription factor. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Repressor
In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. A DNA-binding repressor blocks the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes into messenger RNA. An RNA-binding repressor binds to the mRNA and prevents translation of the mRNA into protein. This blocking or reducing of expression is called repression. Function If an inducer, a molecule that initiates the gene expression, is present, then it can interact with the repressor protein and detach it from the operator. RNA polymerase then can transcribe the message (expressing the gene). A co-repressor is a molecule that can bind to the repressor and make it bind to the operator tightly, which decreases transcription. A repressor that binds with a co-repressor is termed an ''aporepressor'' or ''inactive repressor''. One type of aporepressor is the trp repre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FOXA1
Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the ''FOXA1'' gene. Structure FOXA1 is a member of the forkhead domain transcription factor family. The forkhead domain is essential for its DNA-binding function, and consists of three alpha helices, three beta strands, and two loops (called "wings"). The domain binds along the DNA major groove and the wings directly contact the DNA. FOXA1 is modified by the O-GlcNAc post-translational modification. Function FOXA1 is a pioneer factor, a transcription factor that directly binds condensed chromatin, facilitating the binding of other transcription factors. In prostate cells, FOXA1 interacts with the androgen receptor (AR) to drive transcription of prostate-specific genes. FOXA1 is a member of the forkhead class of DNA-binding proteins. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Estrogen Receptor
Estrogen receptors (ERs) are proteins found in cell (biology), cells that function as receptor (biochemistry), receptors for the hormone estrogen (17β-estradiol). There are two main classes of ERs. The first includes the intracellular estrogen receptors, namely ERα and ERβ, which belong to the nuclear receptor family. The second class consists of membrane estrogen receptors (mERs), such as GPER (GPR30), ER-X, and Gq-mER, Gq-mER, which are primarily G protein-coupled receptors. This article focuses on the nuclear estrogen receptors (ERα and ERβ). Upon activation by estrogen, intracellular ERs undergo protein targeting, translocation to the nucleus where they bind to specific DNA sequences. As DNA-binding transcription factors, they regulate the activity of various genes. However, ERs also exhibit functions that are independent of their DNA-binding capacity. These non-genomic actions contribute to the diverse effects of estrogen signaling in cells. Estrogen receptors (ERs) b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormone
A hormone (from the Ancient Greek, Greek participle , "setting in motion") is a class of cell signaling, signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physiology and behavior. Hormones are required for the normal development of animals, plants and fungi. Due to the broad definition of a hormone (as a signaling molecule that exerts its effects far from its site of production), numerous kinds of molecules can be classified as hormones. Among the substances that can be considered hormones, are eicosanoids (e.g. prostaglandins and thromboxanes), steroids (e.g. Estrogen, oestrogen and brassinosteroid), amino acid derivatives (e.g. epinephrine and auxin), protein or peptides (e.g. insulin and CLE peptides), and gases (e.g. ethylene and nitric oxide). Hormones are used to communicate between organ (anatomy), organs and Tissue (biology), tissues. In vertebrates, hormones are responsible for regulating ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Preinitiation Complex
The preinitiation complex (abbreviated PIC) is a complex of approximately 100 proteins that is necessary for the transcription (genetics), transcription of protein-coding genes in eukaryotes and archaea. The preinitiation complex positions RNA polymerase II (Pol II) at gene transcription start sites, DNA melting, denatures the DNA, and positions the DNA in the RNA polymerase II active site for transcription. The minimal PIC includes RNA polymerase II and six general transcription factors: Transcription factor II A, TFIIA, Transcription factor II B, TFIIB, Transcription factor II D, TFIID, Transcription factor II E, TFIIE, Transcription factor II F, TFIIF, and Transcription factor II H, TFIIH. Additional regulatory complexes (such as the mediator (coactivator), mediator coactivator and chromatin structure remodeling (RSC) complex, chromatin remodeling complexes) may also be components of the PIC. Preinitiation complexes are also formed during RNA Polymerase I and RNA Polymerase II ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enhancer (genetics)
In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins ( activators) to increase the likelihood that transcription of a particular gene will occur. These proteins are usually referred to as transcription factors. Enhancers are ''cis''-acting. They can be located up to 1 Mbp (1,000,000 bp) away from the gene, upstream or downstream from the start site. There are hundreds of thousands of enhancers in the human genome. They are found in both prokaryotes and eukaryotes. Active enhancers typically get transcribed as enhancer or regulatory non-coding RNA, whose expression levels correlate with mRNA levels of target genes. The first discovery of a eukaryotic enhancer was in the immunoglobulin heavy chain gene in 1983. This enhancer, located in the large intron, provided an explanation for the transcriptional activation of rearranged Vh gene promoters while unrearranged Vh promoters remained inactive. Lately, enhancers have been shown to be in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pioneer Factor's Role In Response Of The External Signal
Pioneer commonly refers to a person who is among the first at something that is new to a community. A pioneer as a settler is among the first settling at a place that is new to the settler community. A historic example are American pioneers, persons in American history who migrated westward to settle in what is now the Western and Midwestern United States. Pioneer, The Pioneer, or pioneering may also refer to: Companies and organizations *Pioneer Aerospace Corporation *Pioneer Chicken, an American fast-food restaurant chain *Pioneer Club Las Vegas, a casino in Las Vegas, Nevada, U.S. *Pioneer Corporation, a Japanese electronics manufacturer *Pioneer Energy, a Canadian gas station chain *Pioneer Entertainment, a Japanese anime company *Pioneer Fund, racist foundation, 1937 *Pioneer Hi-Bred, a U.S.-based agriculture company *Pioneer Hotel & Gambling Hall, Laughlin, Nevada, U.S. *Pioneer Instrument Company, an American aeronautical instrument manufacturer *Pioneer movement, a commu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
