P2Y6
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P2Y6
P2Y purinoceptor 6 is a protein that in humans is encoded by the ''P2RY6'' gene. Function The product of this gene, P2Y6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to Uridine diphosphate, UDP, partially responsive to Uridine triphosphate, UTP and Adenosine diphosphate, ADP, and not responsive to Adenosine triphosphate, ATP. Four transcript variants encoding the same isoform have been identified for this gene. See also * P2Y receptor References Further reading * * * * * * * * * * * * * * * External links

* G protein-coupled receptors {{transmembranereceptor-stub ...
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P2Y Receptor
P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development. Structure P2Y receptors are membrane proteins belonging to the class A family of G protein-coupled receptors (GPCRs). P2Y receptor proteins display large-scale structural domains typical of GPCRs, consisting of seven hydrophobic transmembrane helices connected by three short extracellular loops and three variably ...
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