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Ononetin
Ononetin is a natural product from the deoxybenzoin group, which is found in the Russian traditional medicine plant ''Ononis spinosa''. It acts as an inhibitor of the transient receptor potential ion channel TRPM3 and has analgesic effects in animal studies, as well as being used for research into the role of TRPM3 in the immune system dysfunction associated with chronic fatigue syndrome Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling Chronic condition, chronic illness. People with ME/CFS experience profound fatigue that does not go away with rest, as well as sleep issues and problems with memory .... References {{Transient receptor potential channel modulators Ion channel blockers Phenyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TRPM3
Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the ''TRPM3'' gene. Function The product of this gene belongs to the family of Transient receptor potential channel, transient receptor potential (TRP) channels. TRP channels are Ca2+ permeable non-selective Ion channel, cation channels that play roles in a wide variety of physiological processes, including calcium signaling, Temperature sensation, heat and cold sensation, calcium and magnesium homeostasis. TRPMs mediates sodium and calcium entry, which induces depolarization and a cytoplasmic Calcium signaling, Ca2+ signal. Alternatively spliced transcript variants encoding different isoforms have been -identified. TRPM3 was shown to be activated by the neurosteroid pregnenolone sulfate as well as the synthetic compound CIM-0216, CIM0216. Peripheral heat sensation TRPM3 is expressed in peripheral sensory neurons of the Dorsal root ganglion, dorsal root ganglia, and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ononis Spinosa
''Ononis'' is a large genus of perennial In horticulture, the term perennial ('' per-'' + '' -ennial'', "through the year") is used to differentiate a plant from shorter-lived annuals and biennials. It has thus been defined as a plant that lives more than 2 years. The term is also ... herbs and shrubs from the legume family Fabaceae. The members of this genus are often called restharrows or wrestharrows as some species grow as weeds on arable lands whose tough stems would stop the harrow. They are natively distributed in Europe. In herbalism restharrow is used to treat bladder and kidney problems and water retention. The active ingredients in restharrow are essential oils, flavonoid- glycosides, and tannins. Restharrows are used as food plants by the larvae of some Lepidoptera species including the grey pug and '' Coleophora ononidella'' (which feeds exclusively on ''O. arvensis''). Species of ''Ononis'' The genus ''Ononis'' includes the following acce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and anesthetic effects. Analgesic choice is also determined by the type of pain: For neuropathic pain, recent research has suggested that classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants may be considered as an alternative. Various analgesics, such as many NSAIDs, are available over the counter in most countries, whereas various others are prescription drugs owing to the substantial risks and high chances of overdose, misuse, and addiction in the absence of medical supervision. Etymology The word ''analgesic'' derive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune System
The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to bacteria, as well as Tumor immunology, cancer cells, Parasitic worm, parasitic worms, and also objects such as wood splinters, distinguishing them from the organism's own healthy biological tissue, tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered. Both use humoral immunity, molecules and cell-mediated immunity, cells to perform their functions. Nearly all organisms have some kind of immune system. Bacteria have a rudimentary immune system in the form of enzymes that protect against bacteriophage, viral infections. Other basic immune mechanisms evolved in ancien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling Chronic condition, chronic illness. People with ME/CFS experience profound fatigue that does not go away with rest, as well as sleep issues and problems with memory or concentration. The Pathognomonic, hallmark symptom is post-exertional malaise (PEM), a worsening of the illness which can start immediately or hours to days after even minor physical or mental activity. This "crash" can last from hours or days to several months. Further common symptoms include orthostatic intolerance, dizziness or faintness when upright and pain. The cause of the disease is unknown. ME/CFS often starts after an infection, such as infectious mononucleosis, mononucleosis. It can run in families, but no genes that contribute to ME/CFS have been confirmed. ME/CFS is associated with changes in the nervous and immune systems, as well as in energy production. Diagnosis is based on distinctive symptoms, and a differential diag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Channel Blockers
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a Physiology, physiological response in a cell. Channel blocking is conducted by different types of molecules, such as cations, anions, amino acids, and other chemicals. These blockers act as ion channel Receptor antagonist, antagonists, preventing the response that is normally provided by the opening of the channel. Ion channels permit the selective passage of ions through cell membranes by utilizing proteins that function as pores, which allow for the passage of electrical charge in and out of the cell. These ion channels are most often gated, meaning they require a specific stimulus to cause the channel to open and close. These ion channel types regulate the flow of charged ions across the membrane and therefore mediate membrane potential of the cell. Molecules that act as channel blockers are important in the field of pharmacology, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
