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Mütter Museum
The Mütter Museum is a medical museum located in the Center City area of Philadelphia, Pennsylvania. It contains a collection of anatomical and pathological specimens, wax models, and antique medical equipment. The museum is part of The College of Physicians of Philadelphia. The original purpose of the collection, donated by Dr. Thomas Dent Mütter in 1858, was for biomedical research and education. Collections The Mütter Museum originated as a collection of specimens and medical tools used for education in medicine. The museum has a collection of over 20,000 specimens, of which about 10% were on display as of 2018. This does not include the large literary collection contained within the Historical Medical Library, which is also housed within the College of Physicians of Philadelphia. Osteological (skeletal) specimens The Mütter Museum is home to over 3,000 osteological specimens, including several full skeletons. One of the most famous of these is the fully articulat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
College Of Physicians Of Philadelphia
The College of Physicians of Philadelphia is the oldest private medical society in the United States. Founded in 1787 by 24 Philadelphia physicians "to advance the Science of Medicine, and thereby lessen human misery, by investigating the diseases and remedies which are peculiar to our country" and to promote "order and uniformity in the practice of Physick," it has made important contributions to medical education and research. The College hosts the Mütter Museum, a gallery of 19th-century specimens, teaching models, instruments, and photographs, as well as the Historical Medical Library, which is one of the country's oldest medical libraries. The College of Physicians of Philadelphia Building, designed by the firm of Cope & Stewardson and built in 1909, was designated a U.S. National Historic Landmark in October, 2008. It was also then listed on the National Register of Historic Places. Current programs The College remains a private membership organization of physicians, whos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research
Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from " basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific pharmaceutical purpose. The need for fundamental and mechanism-based understanding, diagnostics, medical devices, and non-pharmaceutical therapies means that pharmaceutical research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Wilkes Booth
John Wilkes Booth (May 10, 1838 – April 26, 1865) was an American stage actor who assassinated United States President Abraham Lincoln at Ford's Theatre in Washington, D.C., on April 14, 1865. A member of the prominent 19th-century Booth theatrical family from Maryland, he was a noted actor who was also a Confederate sympathizer; denouncing President Lincoln, he lamented the recent abolition of slavery in the United States. Originally, Booth and his small group of conspirators had plotted to kidnap Lincoln to aid the Confederate cause. They later decided to murder him, as well as Vice President Andrew Johnson and Secretary of State William H. Seward. Although its Army of Northern Virginia, commanded by General Robert E. Lee, had surrendered to the Union Army four days earlier, Booth believed that the Civil War remained unresolved because the Confederate Army of General Joseph E. Johnston continued fighting. Booth shot President Lincoln once in the back of the he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chang And Eng Bunker
Chang Bunker and Eng Bunker (May 11, 1811 – January 17, 1874) were Siamese-American conjoined twin brothers whose fame propelled the expression " Siamese twins" to become synonymous for conjoined twins in general. They were widely exhibited as curiosities and were "two of the nineteenth century's most studied human beings". The brothers were born with Chinese ancestry in Siam (now known as Thailand) and were brought to the United States in 1829. Physicians inspected them as they became known to American and European audiences in "freak shows". Newspapers and the public were initially sympathetic to them, and within three years they left the control of their managers, who they thought were cheating them, and toured on their own. In early exhibitions, they appeared exotic and displayed their athleticism; they later held conversations in English in a more dignified parlor setting. In 1839, after a decade of financial success, the twins quit touring and settled near Mount Airy, No ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conjoined Twins
Conjoined twins – sometimes popularly referred to as Siamese twins – are twins joined ''Uterus, in utero''. A very rare phenomenon, the occurrence is estimated to range from 1 in 49,000 births to 1 in 189,000 births, with a somewhat higher incidence in Southwest Asia and Africa. Approximately half are stillbirth, stillborn, and an additional one-third die within 24 hours. Most live births are female, with a ratio of 3:1. Two theories exist to explain the origins of conjoined twins. The more generally accepted theory is ''fission'', in which the fertilized egg splits partially. The other theory, no longer believed to be the basis of conjoined twinning, is ''fusion'', in which a fertilized egg completely separates, but stem cells (which search for similar cells) find similar stem cells on the other twin and fuse the twins together. Conjoined twins share a single common chorion, placenta, and amniotic sac, although these characteristics are not exclusive to conjoined twins, as th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the right upper quadrant of the abdomen, below the diaphragm. Its other roles in metabolism include the regulation of glycogen storage, decomposition of red blood cells, and the production of hormones. The liver is an accessory digestive organ that produces bile, an alkaline fluid containing cholesterol and bile acids, which helps the breakdown of fat. The gallbladder, a small pouch that sits just under the liver, stores bile produced by the liver which is later moved to the small intestine to complete digestion. The liver's highly specialized tissue, consisting mostly of hepatocytes, regulates a wide variety of high-volume biochemical reactions, including the synthesis and breakdown of small and complex molecule ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hard Palate
The hard palate is a thin horizontal bony plate made up of two bones of the facial skeleton, located in the roof of the mouth. The bones are the palatine process of the maxilla and the horizontal plate of palatine bone. The hard palate spans the alveolar arch formed by the alveolar process that holds the upper teeth (when these are developed). Structure The hard palate is formed by the palatine process of the maxilla and horizontal plate of palatine bone. It forms a partition between the nasal passages and the mouth. On the anterior portion of the hard palate are the plicae, irregular ridges in the mucous membrane that help facilitate the movement of food backward towards the larynx. This partition is continued deeper into the mouth by a fleshy extension called the soft palate. On the ventral surface of hard palate, some projections or transverse ridges are present which are called as palatine rugae. Function The hard palate is important for feeding and speech. Mammals with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grover Cleveland
Stephen Grover Cleveland (March 18, 1837June 24, 1908) was an American lawyer and politician who served as the 22nd and 24th president of the United States from 1885 to 1889 and from 1893 to 1897. Cleveland is the only president in American history to serve two non-consecutive terms in office. He won the popular vote for three presidential elections—in 1884, 1888, and 1892—and was one of two Democrats (followed by Woodrow Wilson in 1912) to be elected president during the era of Republican presidential domination dating from 1861 to 1933. In 1881, Cleveland was elected mayor of Buffalo, and in 1882, he was elected governor of New York. He was the leader of the pro-business Bourbon Democrats who opposed high tariffs, free silver, inflation, imperialism, and subsidies to business, farmers, or veterans. His crusade for political reform and fiscal conservatism made him an icon for American conservatives of the era. Cleveland won praise for his honesty, self-relia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neoplasm
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potentially m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malignancy
Malignancy () is the tendency of a medical condition to become progressively worse. Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties. Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes. Cancers usually show tumour heterogeneity, containing multiple subclones. They also frequently have reduced expression of DNA repair enzymes due to epigenetic methylation of DNA repair genes or altered microRNAs that control DNA repair gene expression. Tumours can be detected through the visual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teratology
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology. The related term developmental toxicity includes all manifestations of abnormal development that are caused by environmental insult. These may include growth retardation, delayed mental development or other congenital disorders without any structural malformations. Teratogens are substances that may cause birth defects via a toxic effect on an embryo or fetus. Known teratogens include: retinol, thalidomide, mercury, alcohol, lead, polychlorinated biphenyls (PCBs), and 2,3,7,8-tetrachlorodibenzodioxin. Etymology The term was borrowed in 1842 from the French , where it was formed in 1830 from the Greek (word stem ), meaning "sign sent by the gods, portent, marvel, monster", and ('' -ology''), used to designate a discourse, treaty, science, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Josef Hyrtl
Josef Hyrtl (7 December 1810 – 17 July 1894) was an Austrian anatomist. Biography Hyrtl was born at Kismarton, Hungary (now Eisenstadt, Austria). He began his medical studies in Vienna in 1831, having received his preliminary education in his native town. His parents were poor, and he had to find funds to defray the expenses of his medical education. In 1833, while he was still a student, he was named prosector in anatomy, and the preparations which this position required him to make for teaching purposes attracted the attention of professors as well as students. His graduation thesis, ''Antiquitates anatomicæ rariores'', was a prophecy of the work to which his life was to be devoted. On graduation he became Prof. Czermak's assistant (famulus) and later became also the curator of the museum. He added valuable treasures to the museum by the preparations which he made for it. As a student he set up a little laboratory and dissecting room in his lodgings, and his injections o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
