|
Motoo Kimura
(November 13, 1924 – November 13, 1994) was a Japanese biologist best known for introducing the neutral theory of molecular evolution in 1968. He became one of the most influential theoretical population geneticists. He is remembered in genetics for his innovative use of diffusion equations to calculate the probability of fixation of beneficial, deleterious, or neutral alleles. Combining theoretical population genetics with molecular evolution data, he also developed the neutral theory of molecular evolution in which genetic drift is the main force changing allele frequencies. James F. Crow, himself a renowned population geneticist, considered Kimura to be one of the two greatest evolutionary geneticists, along with Gustave Malécot, after the great trio of the modern synthesis, Ronald Fisher, J. B. S. Haldane, and Sewall Wright. Life and work Kimura was born on November 13, 1924, in Okazaki, Aichi Prefecture. From an early age he was very interested in botany, thoug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Okazaki, Aichi
is a Cities of Japan, city located in Aichi Prefecture, Japan. , the city had an estimated population of 386,999 in 164,087 households, and a population density of 999 persons per km2. The total area of the city was . Geography Okazaki is in the coastal plains of southeastern Aichi Prefecture. The ground rises to undulating hills in the former Nukata area to the northeast. About 60 percent of the city area is forested and remains sparsely populated. Okazaki is about from Tokyo, to the southwest. Climate The city has a climate characterized by hot and humid summers, and relatively mild winters (Köppen climate classification ''Cfa''). The average annual temperature in Okazaki is . The average annual rainfall is with September as the wettest month. The temperatures are highest on average in August, at around , and lowest in January, at around . Demographics Per Japanese census data, the population of Okazaki has grown steadily over the past 60 years. This fast population growt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biologist
A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological interaction, interacting populations. They usually specialize in a particular Outline of biology#Subdisciplines, branch (e.g., molecular biology, zoology, and evolutionary biology) of biology and have a specific research focus (e.g., studying malaria or cancer). Biologists who are involved in basic research have the aim of advancing knowledge about the natural world. They conduct their research using the scientific method, which is an empirical method for testing hypothesis, hypotheses. Their discoveries may have Applied science#Applied research, applications for some specific purpose such as in biotechnology, which has the goal of developing medically useful products for humans. In modern times, most biologists have one or more academic degre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ronald Fisher
Sir Ronald Aylmer Fisher (17 February 1890 – 29 July 1962) was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, Fisher was the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin, as his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the Modern synthesis (20th century), modern synthesis. For his contributions to biology, Richard Dawkins declared Fisher to be the greatest of Darwin's successors. He is also considered one of the founding fathers of Neo-Darwinism. According to statistician Jeffrey T. Leek, Fisher is the most in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modern Synthesis (20th Century)
The modern synthesis was the early 20th-century synthesis of Charles Darwin's theory of evolution and Gregor Mendel's ideas on Mendelian inheritance, heredity into a joint mathematical framework. Julian Huxley coined the term in his 1942 book, ''Evolution: The Modern Synthesis''. The synthesis combined the ideas of natural selection, Mendelian inheritance, Mendelian genetics, and population genetics. It also related the broad-scale macroevolution seen by paleontology, palaeontologists to the small-scale microevolution of local population, populations. The synthesis was defined differently by its founders, with Ernst Mayr in 1959, G. Ledyard Stebbins in 1966, and Theodosius Dobzhansky in 1974 offering differing basic postulates, though they all include natural selection, working on heritable variation supplied by mutation. Other major figures in the synthesis included E. B. Ford, Bernhard Rensch, Ivan Schmalhausen, and George Gaylord Simpson. An early event in the modern synthesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gustave Malécot
Gustave Malécot (28 December 1911 – November 1998) was a French mathematician whose work on heredity had a strong influence on population genetics. Biography Malécot grew up in L'Horme, a small village near St. Étienne in the Loire département, the son of a mining engineer. In 1935, Malécot obtained a degree in mathematics from the École Normale Supérieure, Paris. He then went on to do a PhD under George Darmois and completed that in 1939. His work focused on R.A. Fisher's 1918 article ''The Correlation Between Relatives on the Supposition of Mendelian Inheritance''. Between 1940 and 1942, with France under Nazi German occupation, Malécot taught mathematics at the Lyceé de Saint-Étienne. In 1942 he was appointed maître de conférence (lecturer) Université de Montpellier. In 1945 he joined the Université de Lyon, becoming professor of applied mathematics Applied mathematics is the application of mathematics, mathematical methods by different fields ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John H
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died ), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (died ), one of the twelve apostles of Jesus Christ * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope Joh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tomoko Ohta
is a Japanese scientist and Professor Emeritus of the National Institute of Genetics. Ohta works on population genetics/ molecular evolution and is known for developing the nearly neutral theory of evolution. Ohta has received many awards, including Japan's Order of Culture (2016). In 2015, Ohta and Richard Lewontin were jointly awarded the Crafoord Prize "for their pioneering analyses and fundamental contributions to the understanding of genetic polymorphism". Education Tomoko Ohta was born near Nagoya and grew up in Miyoshi-cho in Aichi Prefecture. She was in the 6th grade in elementary school when World War II ended. After the war, there were widespread changes in the social and educational systems, including the introduction of co-education. She attended junior high school in Toyota, and became interested in mathematics and physics. After senior high school, she entered Nagoya University. Having failed the examination for medical school, she transferred to the agricul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allele Frequency
Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size. Microevolution is the change in allele frequencies that occurs over time within a population. Given the following: # A particular locus on a chromosome and a given allele at that locus # A population of ''N'' individuals with ploidy ''n'', i.e. an individual carries ''n'' copies of each chromosome in their somatic cells (e.g. two chromosomes in the cells of diploid species) # The allele exists in ''i'' chromosomes in the population then the allele frequency is the fraction of all the occurrences ''i'' of that allele and the total number of chromosome copies across the population, ''i''/(''nN''). The allele frequency is distinct from the genotype frequency, although they a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Drift
Genetic drift, also known as random genetic drift, allelic drift or the Wright effect, is the change in the Allele frequency, frequency of an existing gene variant (allele) in a population due to random chance. Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation. It can also cause initially rare alleles to become much more frequent and even fixed. When few copies of an allele exist, the effect of genetic drift is more notable, and when many copies exist, the effect is less notable (due to the law of large numbers). In the middle of the 20th century, vigorous debates occurred over the relative importance of natural selection versus neutral processes, including genetic drift. Ronald Fisher, who explained natural selection using Mendelian inheritance, Mendelian genetics, held the view that genetic drift plays at most a minor role in evolution, and this remained the dominant view for several decades. In 1968, population geneticist Mot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Evolution
Molecular evolution describes how Heredity, inherited DNA and/or RNA change over evolutionary time, and the consequences of this for proteins and other components of Cell (biology), cells and organisms. Molecular evolution is the basis of phylogenetics, phylogenetic approaches to describing the Tree of life (biology), tree of life. Molecular evolution overlaps with population genetics, especially on shorter timescales. Topics in molecular evolution include the origins of new genes, the genetic nature of complex traits, the genetic basis of adaptation and speciation, the Evolutionary developmental biology, evolution of development, and patterns and processes underlying genome, genomic changes during evolution. History The history of molecular evolution starts in the early 20th century with comparative biochemistry, and the use of "fingerprinting" methods such as immune assays, gel electrophoresis, and paper chromatography in the 1950s to explore homologous proteins. The advent of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allele
An allele is a variant of the sequence of nucleotides at a particular location, or Locus (genetics), locus, on a DNA molecule. Alleles can differ at a single position through Single-nucleotide polymorphism, single nucleotide polymorphisms (SNP), but they can also have insertions and deletions of up to several thousand base pairs. Most alleles observed result in little or no change in the function or amount of the gene product(s) they code or regulate for. However, sometimes different alleles can result in different observable phenotypic traits, such as different pigmentation. A notable example of this is Gregor Mendel's discovery that the white and purple flower colors in pea plants were the result of a single gene with two alleles. Nearly all multicellular organisms have two sets of chromosomes at some point in their biological life cycle; that is, they are diploid. For a given locus, if the two chromosomes contain the same allele, they, and the organism, are homozygous with re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Probability
Probability is a branch of mathematics and statistics concerning events and numerical descriptions of how likely they are to occur. The probability of an event is a number between 0 and 1; the larger the probability, the more likely an event is to occur."Kendall's Advanced Theory of Statistics, Volume 1: Distribution Theory", Alan Stuart and Keith Ord, 6th ed., (2009), .William Feller, ''An Introduction to Probability Theory and Its Applications'', vol. 1, 3rd ed., (1968), Wiley, . This number is often expressed as a percentage (%), ranging from 0% to 100%. A simple example is the tossing of a fair (unbiased) coin. Since the coin is fair, the two outcomes ("heads" and "tails") are both equally probable; the probability of "heads" equals the probability of "tails"; and since no other outcomes are possible, the probability of either "heads" or "tails" is 1/2 (which could also be written as 0.5 or 50%). These concepts have been given an axiomatic mathematical formaliza ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
