|
Mark Daly (scientist)
Mark Joseph Daly is Director of the Finnish Institute for Molecular Medicine (FIMM) at the University of Helsinki, a Professor of Genetics at Harvard Medical School, Chief of the Analytic and Translational Genetic Unit at Massachusetts General Hospital, and a member of the Broad Institute of MIT and Harvard. In the early days of the Human Genome Project, Daly helped develop the genetic model by which linkage disequilibrium could be used to map the haplotype structure of the human genome. In addition, he developed statistical methods to find associations between genes and disorders such as Crohn's disease, inflammatory bowel disease, autism and schizophrenia. Daly is considered a pioneer in the field of human genetics, and is amongst the most cited scientists in the field, and one of the top 100 most cited scientists of all time. He was elected to the National Academy of Medicine in 2017. Education Daly studied physics at MIT, although he initially wanted to become a lawyer or po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Broad Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas UC primarily affects the colon and the rectum. Signs and symptoms In spite of Crohn's and UC being very different diseases, both may present with any of the following symptoms: abdominal pain, diarrhea, rectal bleeding, severe internal cramps/muscle spasms in the region of the pelvis and weight loss. Anemia is the most prevalent extraintestinal complication of inflammatory bowel disease (IBD). Associated complaints or diseases include arthritis, pyoderma gangrenosum, primary sclerosing cholangitis, and non-thyroidal illness syndrome (NTIS). Associations with deep vein thrombosis (DVT) and bronchiolitis obliterans organizing pneumonia (BOOP) have also been reported. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Epidemiologists
Genetic may refer to: *Genetics, in biology, the science of genes, heredity, and the variation of organisms **Genetic, used as an adjective, refers to genes ***Genetic disorder, any disorder caused by a genetic mutation, whether inherited or de novo ***Genetic mutation, a change in a gene ****Heredity, genes and their mutations being passed from parents to offspring **Genetic recombination, refers to the recombining of alleles resulting in a new molecule of DNA *Genetic relationship (linguistics), in linguistics, a relationship between two languages with a common ancestor language *Genetic algorithm In computer science and operations research, a genetic algorithm (GA) is a metaheuristic inspired by the process of natural selection that belongs to the larger class of evolutionary algorithms (EA). Genetic algorithms are commonly used to g ..., in computer science, a kind of search technique modeled on evolutionary biology See also * Genetic memory (other) {{disam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Geneticists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University The American University (AU or A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1967 Births
Events January * January 1 – Canada begins a year-long celebration of the 100th anniversary of Canadian Confederation, Confederation, featuring the Expo 67 World's Fair. * January 6 – Vietnam War: United States Marine Corps and Army of the Republic of Vietnam troops launch ''Operation Deckhouse Five'' in the Mekong Delta. * January 8 – Vietnam War: Operation Cedar Falls starts, in an attempt to eliminate the Iron Triangle (Vietnam), Iron Triangle. * January 13 – A military coup occurs in Togo under the leadership of Étienne Eyadema. * January 15 – Louis Leakey announces the discovery of pre-human fossils in Kenya; he names the species ''Proconsul nyanzae, Kenyapithecus africanus''. * January 23 ** In Munich, the trial begins of Wilhelm Harster, accused of the murder of 82,856 Jews (including Anne Frank) when he led German security police during the German occupation of the Netherlands. He is eventually sentenced to 15 years in prison. ** Milton Keynes in England is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLINK
PLINK is a free, commonly used, open-source whole-genome association analysis toolset designed by Shaun Purcell. The software is designed flexibly to perform a wide range of basic, large-scale genetic analyses. PLINK currently supports following functionalities: * data management; * basic statistics ( FST, missing data, tests of Hardy–Weinberg equilibrium, inbreeding coefficient, etc.); * Linkage disequilibrium (LD) calculation; * Identity by descent (IBD) and identity by state (IBS) matrix calculation; * population stratification, such as a Principal component analysis; * association analysis such as genome-wide association study for both basic case/control studies and quantitative traits; *tests for epistasis Epistasis is a phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed modifier genes. In other words, the effect of the mutation is depe ... Input and ou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haploview
Haploview is a commonly used bioinformatics software which is designed to analyze and visualize patterns of linkage disequilibrium (LD) in genetic data. Haploview can also perform association studies, choosing tag SNPs{{cite journal, author1=de Bakker P. I. , author2=Yelensky R. , author3=Pe'er I. , author4=Gabriel S. B. , author5=Daly M. J. , author6=Altshuler D. , title=Efficiency and power in genetic association studies, journal=Nature Genetics, year=2005, volume=37, pages=1217–23, doi=10.1038/ng1669, pmid=16244653, issue=11 and estimating haplotype frequencies. Haploview is developed and maintained by Dr. Mark Daly's lab at the MIT/Harvard Broad Institute. Haploview currently supports the following functionalities: * LD & haplotype block analysis * Haplotype population frequency estimation * Single SNP and haplotype association tests * Permutation testing for association significance * Implementation of Paul de Bakker's Tagger tag SNP selection algorithm * Automatic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Whitehead Institute
Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally independent entity from the Massachusetts Institute of Technology (MIT), where its 19 members all hold faculty appointments in the MIT Department of Biology or the MIT Department of Bioengineering. , Ruth Lehmann is its director; she succeeded David C. Page. History Whitehead Institute was founded in 1982 by industrialist and philanthropist Edwin C. “Jack” Whitehead (1920–1992), who sought to establish a research institute "dedicated to improving human health through basic biomedical science". Whitehead believed that while such an institution should be closely affiliated with an academic institution, it should remain wholly independent and self-governing. In David Baltimore (1975 Nobel Laureate in Physiology or Medicine), Whitehead ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
