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MRC Human Genetics Unit
The Medical Research Council (UK) Human Genetics Unit is situated at the Western General Hospital in Edinburgh. It is one of the largest MRC research establishments, housing over two hundred scientists, support staff, research fellows, PhD students, and visiting workers. Staff current and former staff at the MRC HGU include: Directors * 1956–1969 Dr Michael Court Brown * 1969–1994 Professor John Evans * 1994–2015 Professor Nicholas Hastie * 2015– Professor Wendy Bickmore Group leaders * Pleasantine Mill * Chris Ponting Sections The Human Genetics Unit is divided into three sections: Biomedical Genomics -Research harnesses the power of large genome-size and population data to reveal the complex nature of disease processes. Section Head: Professor Chris Ponting Genome Regulation -Research focuses on mechanisms that maintain the stability of the genome between cells and between generations, regulate the expression of genes and how changes to these contribute to ...
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Wendy Bickmore
Wendy Anne Bickmore (born 28 July 1961) is a British genome biologist known for her research on the organisation of genomic material in cells. Early life and education Bickmore was born at Shoreham-by-Sea on 28 July 1961 to Beryl and Keith Bickmore. She was educated at Chichester High School for Girls where her interest in science began being influenced by her biology teacher and her parents who were keen amateur gardeners. Her interest in biochemistry was confirmed having read ‘The Chemistry of Life’ by Steven Rose and she went on to study biochemistry at St Hugh's College, Oxford graduating with a BA. She then undertook a PhD at the University of Edinburgh analysing nucleic acid sequences from the Y chromosome of humans. Her supervisors were Howard Cooke and Adrian Bird. She was an independent fellow at the Lister Institute of Preventive Medicine from 1991 until 1996. Research and career Her work has focused on how DNA, chromosomes and specific genes are organised and ...
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Website
A website (also written as a web site) is any web page whose content is identified by a common domain name and is published on at least one web server. Websites are typically dedicated to a particular topic or purpose, such as news, education, commerce, entertainment, or social media. Hyperlinking between web pages guides the navigation of the site, which often starts with a home page. The most-visited sites are Google, YouTube, and Facebook. All publicly-accessible websites collectively constitute the World Wide Web. There are also private websites that can only be accessed on a private network, such as a company's internal website for its employees. Users can access websites on a range of devices, including desktops, laptops, tablets, and smartphones. The app used on these devices is called a web browser. Background The World Wide Web (WWW) was created in 1989 by the British CERN computer scientist Tim Berners-Lee. On 30 April 1993, CERN announced that the ...
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Medical Research Council (UK)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a conseq ...
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Western General Hospital
The Western General Hospital (often abbreviated to simply ‘The Western General’) is a health facility at Craigleith, Edinburgh, Scotland. It is managed by NHS Lothian. History The hospital was designed by Peddie and Kinnear and opened as the St. Cuthberts and Canongate Poorhouse in 1868, principally as a workhouse but also having some hospital functions. It was later renamed Craigleith Poorhouse. In 1915, during the First World War, the building was requisitioned by the War Office to create the 2nd Scottish General Hospital, a facility for the Royal Army Medical Corps to treat military casualties. After returning to poorhouse use in 1920 it was converted fully to hospital use in 1927. A nurses' home was added in 1935 and a pathology block was completed in 1939. It joined the National Health Service in 1948 and a new library was completed in 1979. The first Maggie's Cancer Caring Centre opened on the Western General Hospital site in 1996. In June 2012 the Medicine for th ...
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Edinburgh
Edinburgh is the capital city of Scotland and one of its 32 Council areas of Scotland, council areas. The city is located in southeast Scotland and is bounded to the north by the Firth of Forth and to the south by the Pentland Hills. Edinburgh had a population of in , making it the List of towns and cities in Scotland by population, second-most populous city in Scotland and the List of cities in the United Kingdom, seventh-most populous in the United Kingdom. The Functional urban area, wider metropolitan area had a population of 912,490 in the same year. Recognised as the capital of Scotland since at least the 15th century, Edinburgh is the seat of the Scottish Government, the Scottish Parliament, the Courts of Scotland, highest courts in Scotland, and the Palace of Holyroodhouse, the official residence of the Monarchy of the United Kingdom, British monarch in Scotland. It is also the annual venue of the General Assembly of the Church of Scotland. The city has long been a cent ...
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Nicholas Hastie
Nicholas Dixon Hastie (born 1947) is a British geneticist, and former Director of the MRC Human Genetics Unit at the University of Edinburgh. Education He attended Colwyn Bay Grammar school (it became Ysgol Eirias in 1967), where he sang in the choral society. Hastie was educated at the University of Liverpool and the University of Cambridge. Awards and honours Hastie was elected a Fellow of the Royal Society in 2002. His nomination reads Hastie was also a member of the Faculty of 1000 F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers. F1000 offers a different research evaluation service from standard academic journals by offering peer-review after, rather than .... References {{DEFAULTSORT:Hastie, Nicholas Alumni of the University of Liverpool British geneticists Commanders of the Order of the British Empire Fellows of the Royal Society Fellows of the Royal Society of Edinburgh People from C ...
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Pleasantine Mill
Pleasantine Mill is a cell biologist and group leader at the MRC Human Genetics Unit at the University of Edinburgh. She won the 2018 British Society for Cell Biology Women in Cell Biology Early Career Medal. Early life and education Mill completed her bachelor's degree at McGill University in 1999. She joined University of Toronto for her PhD, working on transcription factors in the Hedgehog signaling pathway in skin development and tumorigenesis supervised by Chi-chung Hui. Her work contributed to the book ''Hedgehog-Gli Signaling in Human Disease.'' She worked at the Hospital for Sick Children and earned her PhD in 2004. Career and research Mill was awarded a Canadian Natural Sciences and Engineering Research Council (NSERC) postdoctoral research fellowship to join the Medical Research Council (MRC) Human Genetics Unit (HGU). She worked on mouse mutagenesis. During her postdoctoral work she identified several novel mutant lines that disrupted developmental signalling. M ...
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Chris Ponting
Christopher Paul Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Chair of Medical Bioinformatics at the University of Edinburgh and group leader in the MRC Human Genetics Unit. He is also an Associate Faculty member of the Wellcome Trust Sanger Institute, a Fellow of the Academy of Medical Sciences, member of the European Molecular Biology Organisation and Fellow of the Royal Society of Edinburgh. His research focuses on long noncoding RNA function and evolution, on single cell biology and on disease genomics. Outside of science, Chris is an amateur novelist and wrote an unpublished, science fiction novel about engineered viruses.The Bioinformatics CRO Podcast'. Episode 2, 2020. Education After receiving his Bachelor of Arts and Master of Science in physics from University of Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his Doctor of Philosophy in ...
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University Of Edinburgh
The University of Edinburgh (, ; abbreviated as ''Edin.'' in Post-nominal letters, post-nominals) is a Public university, public research university based in Edinburgh, Scotland. Founded by the City of Edinburgh Council, town council under the authority of a royal charter from King James VI and I, James VI in 1582 and officially opened in 1583, it is one of Scotland's Ancient universities of Scotland, four ancient universities and the List of oldest universities in continuous operation, sixth-oldest university in continuous operation in the English-speaking world. The university played a crucial role in Edinburgh becoming a leading intellectual centre during the Scottish Enlightenment and contributed to the city being nicknamed the "Etymology of Edinburgh#Athens of the North, Athens of the North". The three main global university rankings (Academic Ranking of World Universities, ARWU, Times Higher Education World University Rankings, THE, and QS World University Rankings, QS) ...
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Cancer Research UK
Cancer Research UK (CRUK) is the world's largest independent cancer research organisation. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and the Imperial Cancer Research Fund. Cancer Research UK conducts research using both its own staff and grant-funded researchers. It also provides information about cancer and runs campaigns aimed at raising awareness and influencing public policy. The organisation's work is almost entirely funded by the public. It raises money through donations, legacies, community fundraising, events, retail and corporate partnerships. Over 25,000 people are regular volunteers. History The Imperial Cancer Research Fund (ICRF) was founded in 1902 as the Cancer Research Fund, changing its name to the Imperial Cancer Research Fund in 1904. It grew over the next twenty years to become one of the world's leading cancer research charities. Its executive committ ...
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Genetics Or Genomics Research Institutions
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the con ...
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Human Genetics
Human genetics is the study of inheritance as it occurs in Human, human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics, and genetic counseling. Genes are the common factor of the qualities of most human-inherited traits. Study of human genetics can answer questions about human nature, can help understand diseases and the development of effective treatment and help us to understand the genetics of human life. This article describes only basic features of human genetics; for the genetics of disorders please see: medical genetics. For information on the genetics of DNA repair defects related to accelerated aging and/or increased risk of cancer please see: DNA repair-deficiency disorder. Genetic differences and inheritance patterns Inheritance of traits for humans are based upon Gregor Mendel's model ...
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