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Lifileucel
Lifileucel, sold under the brand name Amtagvi, is an Adoptive T-cell therapy, adoptive T cell therapy used for the treatment of melanoma. Specifically, lifileucel is a tumor-derived T cell immunotherapy composed of a recipient's own T cells. A portion of the recipient's tumor tissue is removed during a surgical procedure prior to treatment. The recipient's T cells (the tumor-infiltrating lymphocytes) are separated from the tumor tissue, multiplied and then infused into the patient in a single dose. T cells are a type of cell that helps the immune system fight cancer and infections. Lifileucel is the first tumor-derived T cell immunotherapy approved by the US Food and Drug Administration (FDA). It was approved for medical use in the United States in February 2024. Medical uses Lifileucel is indicated for the treatment of adults with unresectable (unable to be removed with surgery) or metastatic (spread to other parts of the body) melanoma previously treated with other the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adoptive T-cell Therapy
Cancer immunotherapy (immuno-oncotherapy) is the stimulation of the immune system to treat cancer, improving the immune system's natural ability to fight the disease. It is an application of the fundamental research of cancer immunology (immuno-oncology) and a growing subspecialty of oncology. Cancer immunotherapy exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can bind to antibody proteins or T-cell receptors, triggering an immune system response. The tumor antigens are often proteins or other macromolecules (e.g., carbohydrates). Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. The clinical success of cancer immunotherapy is highly variable between different forms of cancer; for instance, certain subtypes of gastric cancer react well to the approach whereas immunotherapy is not effec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
