KMUP-1

	KMUP-1 KMUP-1 is a xanthine derivative with phosphodiesterase inhibitor A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cycl ... activity. References {{Phosphodiesterase inhibitors Phosphodiesterase inhibitors Xanthines Piperazines 2-Chlorophenyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Xanthine Xanthine ( or , from Ancient Greek for its yellowish-white appearance; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most human body tissues and fluids, as well as in other organisms. Several stimulants are derived from xanthine, including caffeine, theophylline, and theobromine. Xanthine is a product on the pathway of purine degradation. * It is created from guanine by guanine deaminase. * It is created from hypoxanthine by xanthine oxidoreductase. * It is also created from xanthosine by purine nucleoside phosphorylase. Xanthine is subsequently converted to uric acid by the action of the xanthine oxidase enzyme. Use and production Xanthine is used as a drug precursor for human and animal medications, and is produced as a pesticide ingredient. Clinical significance Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Phosphodiesterase Inhibitor A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this enzyme means that non-specific inhibitors have a wide range of actions, with those in the heart and lungs being some of the first to find therapeutic use. History The different forms or subtypes of phosphodiesterase were initially isolated from rat brains in the early 1970s and were soon afterward shown to be selectively inhibited in the brain and in other tissues by a variety of drugs. The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait. This prediction meanwhile has proved to be true in a variety of fields. Classification Nonselective PDE inhibitors Methylated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Phosphodiesterase Inhibitors A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this enzyme means that non-specific inhibitors have a wide range of actions, with those in the heart and lungs being some of the first to find therapeutic use. History The different forms or subtypes of phosphodiesterase were initially isolated from rat brains in the early 1970s and were soon afterward shown to be selectively inhibited in the brain and in other tissues by a variety of drugs. The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait. This prediction meanwhile has proved to be true in a variety of fields. Classification Nonselective PDE inhibitors Methylated x ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Xanthines Xanthine ( or , from Ancient Greek for its yellowish-white appearance; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base (genetics), base found in most human body tissues and fluids, as well as in other organisms. Several stimulants are derived from xanthine, including caffeine, theophylline, and theobromine. Xanthine is a product on the pathway of purine degradation. * It is created from guanine by guanine deaminase. * It is created from hypoxanthine by xanthine oxidoreductase. * It is also created from xanthosine by purine nucleoside phosphorylase. Xanthine is subsequently converted to uric acid by the action of the xanthine oxidase enzyme. Use and production Xanthine is used as a drug precursor (chemistry), precursor for human and animal medications, and is produced as a pesticide ingredient. Clinical significance Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Piperazines Substituted piperazines are a class of chemical compounds based on a piperazine core. Some are used as recreational drugs and some are used in scientific research. List of substituted piperazines Benzylpiperazines File:Benzylpiperazine.svg, 1-Benzylpiperazine (BZP) File:Methylbenzylpiperazine.svg, 1-Methyl-4-benzylpiperazine (MBZP) File:DBZP.svg, 1,4-Dibenzylpiperazine (DBZP) File:MDBZP.svg, 3,4-Methylenedioxy-1-benzylpiperazine (MDBZP) File:2C-B-BZP.svg, 4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP) File:Methoxypiperamide.png, Methoxypiperamide (MeOP, MEXP) ((4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) File:Sunifiram.svg , Sunifiram (1-benzoyl-4-propanoylpiperazine) File:3-Methylbenzylpiperazine structure.png, 3-Methylbenzylpiperazine (3-MeBZP) File:Befuraline.svg, Befuraline(also produces benzylpiperazine as a metabolite) File:Fipexide.svg, Fipexide(also produces substituted benzylpiperazine as a metabolite) File:Piberaline.svg, Piberaline(also produces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]