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Joseph Smadel
Joseph Edward Smadel (1907–1963) was a U.S. medical doctor and virologist. He introduced chloramphenicol as treatment for rickettsial diseases. In 1962, he became the first recipient of the Albert Lasker Award for Clinical Medical Research . Biography Smadel was born in Vincennes, Indiana, the son of medical doctor Joseph William Smadel and former nurse Clara Greene Smadel. He completed his undergraduate work at the University of Pennsylvania then obtained a medical degree from the Washington University School of Medicine, St. Louis in 1931. It was at Washington University that he met his future wife, Elizabeth Moore. Smadel was a member of the virological team that first recognized an outbreak of St. Louis encephalitis in 1933. Smadel then moved on to New York City to work under scientists Homer Swift and Thomas M. Rivers at the Rockefeller Institute. While there, Smadel took a strong interest in the new field of virology. He formed a productive, long term professional asso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Of America
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Am ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variola
Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making it the only human disease to be eradicated. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash. Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was spread between people or via contaminated objects. Prevention was achieved mainly through the smallpox vaccine. Once the disease had developed, certain antiviral medication may have helped. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemorrhagic Fever
Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection. VHFs may be caused by five distinct families of RNA viruses: the families '' Filoviridae'', '' Flaviviridae'', '' Rhabdoviridae'', and several member families of the '' Bunyavirales'' order such as '' Arenaviridae'', and '' Hantaviridae''. All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in many cases. Some of the VHF agents cause relatively mild illnesses, such as the Scandinavian '' nephropathia epidemica'' (a hantavirus), while others, such as Ebola virus, can cause severe, life-threatening disease. Signs and symptoms Signs and symptoms of VHFs include (by definition) fever and bleeding: * Flushing of the face and chest, small red or purple spots (petechiae), bleeding, swelling caused by edema, low blood pressure ( hypotension), and circulatory shock. * Mala ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plague (disease)
Plague is an infectious disease caused by the bacterium ''Yersinia pestis ''Yersinia pestis'' (''Y. pestis''; formerly '' Pasteurella pestis'') is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both '' Yersinia pseudotuberculosis'' and '' Yersinia enterocolitica''. It is a facu ...''. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms. Pneumonic plague infects the lungs, causing shortness of breath, coughing and chest pain; bubonic plague affects the lymph nodes, making them swell; and septicemic plague infects the blood and can cause tissues to necrosis, turn black and die. The bubonic and septicemic forms are generally spread by flea bites or handling an infected animal, whereas pneumonic plague is generally spread between people Airborne disease, through the air via infectio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leptospirosis
Leptospirosis is a blood infection caused by the bacteria '' Leptospira''. Signs and symptoms can range from none to mild (headaches, muscle pains, and fevers) to severe ( bleeding in the lungs or meningitis). Weil's disease, the acute, severe form of leptospirosis, causes the infected individual to become jaundiced (skin and eyes become yellow), develop kidney failure, and bleed. Bleeding from the lungs associated with leptospirosis is known as severe pulmonary haemorrhage syndrome. More than ten genetic types of ''Leptospira'' cause disease in humans. Both wild and domestic animals can spread the disease, most commonly rodents. The bacteria are spread to humans through animal urine, or water and soil contaminated with animal urine, coming into contact with the eyes, mouth, nose or breaks in the skin. In developing countries, the disease occurs most commonly in farmers and low-income people who live in areas with poor sanitation. In developed countries, it occurs during h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Typhoid Fever
Typhoid fever, also known as typhoid, is a disease caused by '' Salmonella'' serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several days. This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting. Some people develop a skin rash with rose colored spots. In severe cases, people may experience confusion. Without treatment, symptoms may last weeks or months. Diarrhea may be severe, but is uncommon. Other people may carry the bacterium without being affected, but they are still able to spread the disease. Typhoid fever is a type of enteric fever, along with paratyphoid fever. ''S. enterica'' Typhi is believed to infect and replicate only within humans. Typhoid is caused by the bacterium ''Salmonella enterica'' subsp. ''enterica'' serovar Typhi growing in the intestines, peyers patches, mesenteric lymph nodes, spleen, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Normandy Invasion
Operation Overlord was the codename for the Battle of Normandy, the Allied operation that launched the successful invasion of German-occupied Western Europe during World War II. The operation was launched on 6 June 1944 (D-Day) with the Normandy landings. A 1,200-plane airborne assault preceded an amphibious assault involving more than 5,000 vessels. Nearly 160,000 troops crossed the English Channel on 6 June, and more than two million Allied troops were in France by the end of August. The decision to undertake a cross-channel invasion in 1944 was taken at the Trident Conference in Washington in May 1943. General Dwight D. Eisenhower was appointed commander of Supreme Headquarters Allied Expeditionary Force, and General Bernard Montgomery was named commander of the 21st Army Group, which comprised all the land forces involved in the invasion. The coast of Normandy of northwestern France was chosen as the site of the invasion, with the Americans assigned to land at sectors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediterranean
The Mediterranean Sea is a sea connected to the Atlantic Ocean, surrounded by the Mediterranean Basin and almost completely enclosed by land: on the north by Western and Southern Europe and Anatolia, on the south by North Africa, and on the east by the Levant. The Sea has played a central role in the history of Western civilization. Geological evidence indicates that around 5.9 million years ago, the Mediterranean was cut off from the Atlantic and was partly or completely desiccated over a period of some 600,000 years during the Messinian salinity crisis before being refilled by the Zanclean flood about 5.3 million years ago. The Mediterranean Sea covers an area of about , representing 0.7% of the global ocean surface, but its connection to the Atlantic via the Strait of Gibraltar—the narrow strait that connects the Atlantic Ocean to the Mediterranean Sea and separates the Iberian Peninsula in Europe from Morocco in Africa—is only wide. The Mediterr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Typhus Fever
Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure. The diseases are caused by specific types of bacterial infection. Epidemic typhus is due to ''Rickettsia prowazekii'' spread by body lice, scrub typhus is due to ''Orientia tsutsugamushi'' spread by chiggers, and murine typhus is due to ''Rickettsia typhi'' spread by fleas. Vaccines have been developed, but none are commercially available. Prevention is achieved by reducing exposure to the organisms that spread the disease. Treatment is with the antibiotic doxycycline. Epidemic typhus generally occurs in outbreaks when poor sanitary conditions and crowding are present. While once common, it is now rare. Scrub typhus occurs in Southeast Asia, Japan, and northern Australia. Murine typhus occurs in tropical and subtropical areas of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Theater
The European theatre of World War II was one of the two main theatres of combat during World War II. It saw heavy fighting across Europe for almost six years, starting with Germany's invasion of Poland on 1 September 1939 and ending with the Western Allies conquering most of Western Europe, the Soviet Union conquering most of Eastern Europe and Germany's unconditional surrender on 8 May 1945 (9 May in the Soviet Union) but the fighting on the Eastern front continued until 11 May during the Prague offensive and the end of the Battle of Odzak on 25 May. The Allied powers fought the Axis powers on two major fronts ( Eastern Front and Western Front) as well as in a strategic bombing offensive and in the adjoining Mediterranean and Middle East theatre. Preceding events Germany was defeated in World War I, and the Treaty of Versailles placed punitive conditions on the country, including significant financial reparations, the loss of territory (some only temporarily), war gui ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First Medical General Laboratory
First or 1st is the ordinal form of the number one (#1). First or 1st may also refer to: *World record, specifically the first instance of a particular achievement Arts and media Music * 1$T, American rapper, singer-songwriter, DJ, and record producer Albums * ''1st'' (album), a 1983 album by Streets * ''1st'' (Rasmus EP), a 1995 EP by The Rasmus, frequently identified as a single * ''1ST'', a 2021 album by SixTones * ''First'' (Baroness EP), an EP by Baroness * ''First'' (Ferlyn G EP), an EP by Ferlyn G * ''First'' (David Gates album), an album by David Gates * ''First'' (O'Bryan album), an album by O'Bryan * ''First'' (Raymond Lam album), an album by Raymond Lam * ''First'', an album by Denise Ho Songs * "First" (Cold War Kids song), a song by Cold War Kids * "First" (Lindsay Lohan song), a song by Lindsay Lohan * "First", a song by Everglow from ''Last Melody'' * "First", a song by Lauren Daigle * "First", a song by Niki & Gabi * "First", a song by Jonas Brothe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walter Reed Army Institute Of Research
The Walter Reed Army Institute of Research (WRAIR) is the largest biomedical research facility administered by the U.S. Department of Defense (DoD). The institute is centered at the Forest Glen Annex, in the Forest Glen Park part of the unincorporated Silver Spring urban area in Maryland just north of Washington, DC, but it is a subordinate unit of the U.S. Army Medical Research and Development Command (USAMRDC), headquartered at nearby Fort Detrick, Maryland. At Forest Glen, the WRAIR has shared a laboratory and administrative facility — the Sen Daniel K. Inouye Building, also known as Building 503 — with the Naval Medical Research Center since 1999. The Institute takes its name from Major Walter Reed, MD (1851–1902), the Army physician who, in 1901, led the team that confirmed the theory that yellow fever is transmitted by a particular mosquito species, rather than by direct contact. Today, the WRAIR fosters and performs biomedical research for the DoD and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
