IgaA

	IgaA IgaA (''intracellular growth attenuator A'') is a conserved bacterial membrane protein involved in the negative regulation of the Rcs phosphorelay system, a signaling pathway that controls envelope stress responses in many Gram-negative bacteria. The protein is essential for bacterial viability in several species, including ''Salmonella enterica'', and plays a key role in modulating growth and virulence. Function IgaA is a multi-pass inner membrane protein that suppresses activation of the RcsCDB phosphorelay system under non-stress conditions. When functioning properly, IgaA prevents unnecessary activation of envelope stress responses, helping maintain homeostasis and prevent toxic overexpression of capsular polysaccharides and other surface components. Loss-of-function mutations in ''igaA'' lead to constitutive activation of Rcs signaling, resulting in defects in cell division, envelope structure, and motility, and in some cases a reduction in virulence. Structure IgaA ty ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Rcs Phosphorelay System RCS may refer to: Organizations Arts and entertainment Radio Corporation of Singapore Radcliffe Choral Society, a choral ensemble at Harvard University RCS MediaGroup (Rizzoli-Corriere della Sera), an Italian publishing group Royal Conservatoire of Scotland Ryan Cayabyab Singers, a Philippine band Education Rawmarsh Community School, South Yorkshire, England * Richmond Christian School Riverdale Country School, Bronx, New York Rogersville City School * Rosehill Christian School Royal College of Science Royal College of Surgeons Military * Radar cross section * Regional Command — South (RC-S), of Afghanistan's International Security Assistance Force * Royal Corps of Signals Sport Racing Club de Strasbourg Alsace, a French football club Representation of Czechs and Slovaks, a football team Other organisations Red Crescent Society Red Cross Society Romania Cable Systems RCS Motor Club, who maintain an antique fire engine for the Royal College of Science ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Pfam Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models. The latest version of Pfam, 37.0, was released in June 2024 and contains 21,979 families. It is currently provided through InterPro website. Uses The general purpose of the Pfam database is to provide a complete and accurate classification of protein families and domains. Originally, the rationale behind creating the database was to have a semi-automated method of curating information on known protein families to improve the efficiency of annotating genomes. The Pfam classification of protein families has been widely adopted by biologists because of its wide coverage of proteins and sensible naming conventions. It is used by experimental biologists researching specific proteins, by structural biologists to identify new targets for structure determination, by computational biologists to organise sequences and by evolutionary biologis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Enterobacteriaceae Enterobacteriaceae is a large family (biology), family of Gram-negative bacteria. It includes over 30 genera and more than 100 species. Its classification above the level of Family (taxonomy), family is still a subject of debate, but one classification places it in the order Enterobacterales of the class Gammaproteobacteria in the phylum Pseudomonadota. In 2016, the description and members of this family were emended based on comparative genomic analyses by Adeolu et al. Enterobacteriaceae includes, along with many harmless Symbiosis, symbionts, many of the more familiar pathogenic bacteria, pathogens, such as ''Salmonella'', ''Escherichia coli'', ''Klebsiella'', and ''Shigella''. Other disease-causing bacteria in this family include ''Enterobacter'' and ''Citrobacter''. Members of the Enterobacteriaceae can be Bacterial taxonomy#Nomenclature, trivially referred to as enterobacteria or "enteric bacteria", as several members live in the intestines of animals. In fact, the etymol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Molecular Microbiology (journal) ''Molecular Microbiology'' is a bimonthly peer-reviewed scientific journal covering all aspects of molecular microbiology. It was established in 1987 and is published by Wiley-Blackwell. The editor-in-chief is John D. Helmann (Cornell University). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2022 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.6. References External links * {{Official website Academic journals established in 1987 Microbiology journals Wiley-Blackwell academic journals Biweekly journals English-language journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Bacterial Proteins Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal and paras ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Protein Families A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes a corresponding protein with a 1:1 relationship. The term "protein family" should not be confused with family as it is used in taxonomy. Proteins in a family descend from a common ancestor and typically have similar three-dimensional structures, functions, and significant sequence similarity. Sequence similarity (usually amino-acid sequence) is one of the most common indicators of homology, or common evolutionary ancestry. Some frameworks for evaluating the significance of similarity between sequences use sequence alignment methods. Proteins that do not share a common ancestor are unlikely to show statistically significant sequence similarity, making sequence alignment a powerful tool for identifying the members of protein families. Families are sometimes grouped together into larger clades called superfamilies based on stru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Transmembrane Proteins A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them ( beta-barrels) can be also extracted using denaturing agents. The peptide sequence that spans the membrane, or the transmembrane segment, is largely hydrophobic and can be visualized using the hydropathy plot. Depending on the number of transmembrane segments, transmembrane proteins can be classified as single-pass membrane proteins, or as multipass membrane proteins. Some other integral membrane proteins are called monotopic, meaning that they are also permanently attached to the membrane, bu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]