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IVF
In vitro fertilisation (IVF) is a process of fertilisation where an ovum, egg is combined with spermatozoon, sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's Ovulation cycle, ovulatory process, removing an ovum or ova (egg or eggs) from their ovary, ovaries and letting sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is Embryo transfer, transferred by catheter into the uterus, with the intention of establishing a successful pregnancy. IVF is a type of assisted reproductive technology used for infertility treatment, gestational surrogacy, and, in combination with pre-implantation genetic testing, avoiding transmission of genetic conditions. A fertilised egg from a donor may Implantation (embryology), implant into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries have banned or otherwise regulate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Assisted Reproductive Technology
Assisted reproductive technology (ART) includes medical procedures used primarily to address infertility. This subject involves procedures such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), cryopreservation of gametes or embryos, and/or the use of fertility medication. When used to address infertility, ART may also be referred to as fertility treatment. ART mainly belongs to the field of reproductive endocrinology and infertility. Some forms of ART may be used with regard to fertile couples for genetic purpose (see preimplantation genetic diagnosis). ART may also be used in surrogacy arrangements, although not all surrogacy arrangements involve ART. The existence of sterility will not always require ART to be the first option to consider, as there are occasions when its cause is a mild disorder that can be solved with more conventional treatments or with behaviors based on promoting health and reproductive habits. Procedures General With ART, the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Egg Donation
Egg donation is the process by which a woman donates eggs to enable another woman to conceive as part of an assisted reproduction treatment or for biomedical research. For assisted reproduction purposes, egg donation typically involves in vitro fertilization technology, with the eggs being fertilized in the laboratory; more rarely, unfertilized eggs may be frozen and stored for later use. Egg donation is a third party reproduction as part of assisted reproductive technology. In the United States, the American Society for Reproductive Medicine has issued guidelines for these procedures, and the Food and Drug Administration has a number of guidelines as well. There are boards in countries outside of the US which have the same regulations. However, egg donation agencies in the U.S. can choose whether to abide by the society's regulations or not. History The first child born from egg donation was reported in Australia in 1983. In July 1983, a clinic in Southern California reported ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fertility Tourism
Fertility tourism (also referred to as reproductive tourism or cross border reproductive care) is the practice of traveling to another country or jurisdiction for fertility treatment, and may be regarded as a form of medical tourism. One can usually be considered as having fertility issues when they are unable to have a clinical pregnancy after 12 months of attempts with intercourse. Infertility, or the inability to get pregnant, affects about 8-12% of couples looking to conceive or 186 million people globally. In some places, rates of infertility surpass the global average and can go up to 30% depending on the country. Areas with lack of resources, such as assisted reproductive technologies (ARTs), tend to correlate with the highest rates of infertility. The main procedures sought are in vitro fertilization (IVF), artificial insemination by a donor, as well as surrogacy. These methods are types of assisted reproductive technology (ARTs). Each of these three methods have varying p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Geoffrey Edwards
Sir Robert Geoffrey Edwards (27 September 1925 – 10 April 2013) was a British physiologist and pioneer in reproductive medicine, and in-vitro fertilisation (IVF) in particular. Along with obstetrician and gynaecologist Patrick Steptoe and nurse Jean Purdy, Edwards successfully pioneered conception through IVF, which led to the birth of Louise Brown on 1978. They founded the first IVF programme for infertile patients and trained other scientists in their techniques. Edwards was the founding editor-in-chief of ''Human Reproduction'' in 1986. In 2010, he was awarded the Nobel Prize in Physiology or Medicine "for the development of in vitro fertilization". Education and early career Edwards was born in Batley, Yorkshire, and attended Manchester Central High School on Whitworth Street in central Manchester, after which he served in the British Army, and then completed his undergraduate studies in biology, graduating with an Ordinary degree at Bangor University. He studi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jean Purdy
Jean Marian Purdy (25 April 1945 – 16 March 1985) was a British nurse and embryologist and a pioneer of fertility treatment. Purdy was responsible with Robert Edwards and Patrick Steptoe for developing in vitro fertilisation. Louise Joy Brown, the first test-tube baby, was born on 25 July 1978, and Purdy was the first to see the embryonic cells dividing. Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine for his work on the development of in vitro fertilisation; however, because the Nobel Prize is not awarded posthumously, neither Purdy nor Steptoe were eligible for consideration. Purdy was a co-founder of the Bourn Hall Clinic but her role there and in the development of IVF was ignored for 30 years. Education Purdy attended Cambridgeshire High School for Girls between 1956 and 1963 where she became a prefect, joined sports teams and played violin in the orchestra. She trained to be a nurse at Addenbrooke's Hospital in Cambridge. Career After gaini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pre-implantation Genetic Testing
Preimplantation genetic diagnosis (PGD or PIGD) is the genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization. PGD is considered in a similar fashion to prenatal diagnosis. When used to screen for a specific genetic disease, its main advantage is that it avoids selective abortion, as the method makes it highly likely that the baby will be free of the disease under consideration. PGD thus is an adjunct to assisted reproductive technology, and requires in vitro fertilization (IVF) to obtain oocytes or embryos for evaluation. Embryos are generally obtained through blastomere or blastocyst biopsy. The latter technique has proved to be less deleterious for the embryo, therefore it is advisable to perform the biopsy around day 5 or 6 of development. The world's first PGD was performed by Handyside, Kontogianni and Winston at the Hammersmith Hospital in London. Female embryos were selectively transferred i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louise Brown
Louise Joy Brown (born 25 July 1978) is an English woman who was the first human to have been born after conception by ''in vitro'' fertilisation experiment (IVF). Her birth, following a procedure pioneered in Britain, has been lauded among "the most remarkable medical breakthroughs of the 20th Century". Birth and early life Louise Joy Brown was born at Oldham General Hospital, Lancashire, by planned Caesarean section performed by registrar John Webster. She weighed 5 pounds, 12 ounces (2.608 kg) at birth. Her parents, Lesley and John Brown, had been trying to conceive naturally for nine years, but Lesley faced complications of blocked fallopian tubes."World's first IVF baby marks 30th birthday" [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infertility
Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually not the natural state of a healthy adult, except notably among certain eusocial species (mostly haplodiploid insects). It is the normal state of a human child or other young offspring, because they have not undergone puberty, which is the body's start of reproductive capacity. In humans, infertility is the inability to become pregnant after one year of unprotected and regular sexual intercourse involving a male and female partner.Chowdhury SH, Cozma AI, Chowdhury JH. Infertility. Essentials for the Canadian Medical Licensing Exam: Review and Prep for MCCQE Part I. 2nd edition. Wolters Kluwer. Hong Kong. 2017. There are many causes of infertility, including some that medical intervention can treat. Estimates from 1997 suggest that worldwide about five percent of all heterosexual couples have an unresolved problem with infertility. Many more couples, however, experience ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryo Transfer
Embryo transfer refers to a step in the process of assisted reproduction in which embryos are placed into the uterus of a female with the intent to establish a pregnancy. This technique (which is often used in connection with in vitro fertilization (IVF), may be used in humans or in animals, in which situations the goals may vary. Embryo transfer can be done at day two or day three, or later in the blastocyst stage, which was first performed in 1984. Factors that can affect the success of embryo transfer include the endometrial receptivity, embryo quality, and embryo transfer technique. Fresh versus frozen Embryos can be either "fresh" from fertilized egg cells of the same menstrual cycle, or "frozen", that is they have been generated in a preceding cycle and undergone embryo cryopreservation, and are thawed just prior to the transfer, which is then termed "frozen embryo transfer" (FET). The outcome from using cryopreserved embryos has uniformly been positive with no increas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gestational Surrogacy
Surrogacy is an arrangement, often supported by a legal agreement, whereby a woman agrees to delivery/labour for another person or people, who will become the child's parent(s) after birth. People may seek a surrogacy arrangement when pregnancy is medically impossible, when pregnancy risks are dangerous for the intended mother, or when a single man or a male couple wish to have a child. In surrogacy arrangements, monetary compensation may or may not be involved. Receiving money for the arrangement is known as commercial surrogacy. The legality and cost of surrogacy varies widely between jurisdictions, sometimes resulting in problematic international or interstate surrogacy arrangements. Couples seeking a surrogacy arrangement in a country where it is banned sometimes travel to a jurisdiction that permits it. In some countries, surrogacy is legal only if money does not exchange hands. Where commercial surrogacy is legal, couples may use the help of third-party agencies to as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patrick Steptoe
Patrick Christopher Steptoe CBE FRS (9 June 1913 – 21 March 1988) was an English obstetrician and gynaecologist and a pioneer of fertility treatment. Steptoe was responsible with biologist and physiologist Robert Edwards and the nurse Jean Purdy for developing in vitro fertilisation. Louise Joy Brown, the first test-tube baby, was born on 25 July 1978. Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine for his work on the development of in vitro fertilisation; Steptoe and Purdy were not eligible for consideration because the Nobel Prize is not awarded posthumously. Education Born in Oxford, Steptoe was educated at The Grammar School, Witney (since 1968 the comprehensive Henry Box School) in Oxfordshire. He went to King's College London and graduated from St George's Hospital Medical School, London in 1939. He served in the Royal Navy from 1939–1946 and attained the rank of Lieutenant Commander. From 1947 to 1949 he was chief assistant in obstetric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryo Culture
Embryo culture is a component of ''in vitro'' fertilisation where in resultant embryos are allowed to grow for some time in an artificial medium. Duration The duration of embryo culture can be varied, conferring different stages of embryogenesis at embryo transfer. The main stages at which embryo transfer is performed are cleavage stage (day 2 to 4 after co-incubation) or the blastocyst stage (day 5 or 6 after co-incubation). Embryos which reach the day 3 cell stage can be tested for chromosomal or specific genetic defects prior to possible transfer by preimplantation genetic diagnosis (PGD). Embryo culture until the blastocyst stage confers a significant increase in live birth rate per embryo transfer, and there is no evidence of a difference between the groups in cumulative pregnancy rates. Transfer day 2 instead of day 3 after fertilization has no differences in live birth rate. Monozygotic twinning is not increased after blastocyst transfer compared with cleavage-stage emb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
